The Type VI secretion system of Burkholderia cenocepacia affects multiple Rho family GTPases disrupting the actin cytoskeleton and the assembly of NADPH oxidase complex in macrophages

Burkholderia cenocepacia disrupts host cell actin cytoskeleton by inactivating Rac and Cdc42

(2011) Ronald S. Flannagan et al.   CELLULAR MICROBIOLOGY

Bacterial protein toxins that modify host regulatory GTPases

(2011) Klaus Aktories   NATURE REVIEWS MICROBIOLOGY

Type VI Secretion: Not Just for Pathogenesis Anymore

(2010) Andrea J. Jani et al.   Cell Host & Microbe

ROS-inhibitory activity of YopE is required for full virulence of Yersinia in mice

(2010) Warangkhana Songsungthong et al.   CELLULAR MICROBIOLOGY

A bacterial effector targets host DH-PH domain RhoGEFs and antagonizes macrophage phagocytosis

(2010) Na Dong et al.   EMBO JOURNAL

Activation of Rho GTPases in Smith–Lemli–Opitz syndrome: pathophysiological and clinical implications

(2010) Xiao-Sheng Jiang et al.   HUMAN MOLECULAR GENETICS

BcsKCIs an Essential Protein for the Type VI Secretion System Activity inBurkholderia cenocepaciaThat Forms an Outer Membrane Complex with BcsLB

(2010) Daniel Aubert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polarization and Migration of Hematopoietic Stem and Progenitor Cells Rely on the RhoA/ROCK I Pathway and an Active Reorganization of the Microtubule Network

(2010) Ana-Violeta Fonseca et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coordinated RhoA signaling at the leading edge and uropod is required for T cell transendothelial migration

(2010) Sarah J. Heasman et al.   JOURNAL OF CELL BIOLOGY

Spatio-temporal Rho GTPase signaling - where are we now?

(2010) O. Pertz   JOURNAL OF CELL SCIENCE

Inactivation of Macrophage Rab7 by Burkholderia cenocepacia

(2010) Kassidy K. Huynh et al.   Journal of Innate Immunity

Regulation of actin cytoskeleton dynamics in cells

(2010) Sung Haeng Lee et al.   MOLECULES AND CELLS

In vivo actin cross-linking induced by Vibrio cholerae type VI secretion system is associated with intestinal inflammation

(2010) A. T. Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ADF/Cofilin: a functional node in cell biology

(2010) Barbara W. Bernstein et al.   TRENDS IN CELL BIOLOGY

Burkholderia Type VI Secretion Systems Have Distinct Roles in Eukaryotic and Bacterial Cell Interactions

(2010) Sandra Schwarz et al.   PLoS Pathogens

Translocation of a Vibrio cholerae Type VI Secretion Effector Requires Bacterial Endocytosis by Host Cells

(2009) Amy T. Ma et al.   Cell Host & Microbe

Rac1 inactivation by lethal toxin fromClostridium sordelliimodifies focal adhesions upstream of actin depolymerization

(2009) Blandine Geny et al.   CELLULAR MICROBIOLOGY

The type VI secretion system: translocation of effectors and effector-domains

(2009) Stefan Pukatzki et al.   CURRENT OPINION IN MICROBIOLOGY

Burkholderia mallei Cluster 1 Type VI Secretion Mutants Exhibit Growth and Actin Polymerization Defects in RAW 264.7 Murine Macrophages

(2009) M. N. Burtnick et al.   INFECTION AND IMMUNITY

A Type VI Secretion System Effector Protein, VgrG1, from Aeromonas hydrophila That Induces Host Cell Toxicity by ADP Ribosylation of Actin

(2009) G. Suarez et al.   JOURNAL OF BACTERIOLOGY

Sequestering of Rac by theYersiniaEffector YopO Blocks Fcγ Receptor-mediated Phagocytosis

(2009) Eleanor Groves et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The cofilin activity cycle in lamellipodia and invadopodia

(2009) Matthew Oser et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Burkholderia cenocepacia O antigen lipopolysaccharide prevents phagocytosis by macrophages and adhesion to epithelial cells

(2009) M. S. Saldias et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Inhibition of the human neutrophil NADPH oxidase by Coxiella burnetii

(2009) Daniel W. Siemsen et al.   MICROBES AND INFECTION

Delayed association of the NADPH oxidase complex with macrophage vacuoles containing the opportunistic pathogen Burkholderia cenocepacia

(2009) K. E. Keith et al.   MICROBIOLOGY-SGM

Interactions of Burkholderia cenocepacia and other Burkholderia cepacia complex bacteria with epithelial and phagocytic cells

(2009) M. S. Saldias et al.   MICROBIOLOGY-SGM

Antimicrobial mechanisms of phagocytes and bacterial evasion strategies

(2009) Ronald S. Flannagan et al.   NATURE REVIEWS MICROBIOLOGY

Random versus directionally persistent cell migration

(2009) Ryan J. Petrie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The type VI secretion toolkit

(2008) Eric Cascales   EMBO REPORTS

A system for the construction of targeted unmarked gene deletions in the genus Burkholderia

(2008) Ronald S. Flannagan et al.   ENVIRONMENTAL MICROBIOLOGY

A Novel Sensor Kinase-Response Regulator Hybrid Controls Biofilm Formation and Type VI Secretion System Activity in Burkholderia cenocepacia

(2008) D. F. Aubert et al.   INFECTION AND IMMUNITY

Burkholderia cenocepacia-induced delay of acidification and phagolysosomal fusion in cystic fibrosis transmembrane conductance regulator (CFTR)-defective macrophages

(2008) J. Lamothe et al.   MICROBIOLOGY-SGM

Mammalian Rho GTPases: new insights into their functions from in vivo studies

(2008) Sarah J. Heasman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY