Journal
CELLULAR MICROBIOLOGY
Volume 13, Issue 9, Pages 1303-1311Publisher
WILEY
DOI: 10.1111/j.1462-5822.2011.01628.x
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Funding
- CNRS
- Region Nord-Pas-de Calais
- French National Research Agency [MIE09]
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The ubiquitin proteasome system and autophagy constitute key signalling pathways in the host response to infection. The identification of adaptors linking the two pathways has prompted a re-examination of the latter's involvement in inflammatory reactions and the clearance of bacteria. The ubiquitin-autophagy pathway is a preferred target for effectors from pathogens that seek to exploit and evade the host defence mechanisms. A number of new players and signalling nodes have recently been identified. Here, we discuss these new insights into the host's control of bacterial infection.
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