Journal
CELLULAR AND MOLECULAR NEUROBIOLOGY
Volume 33, Issue 8, Pages 1149-1157Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10571-013-9981-0
Keywords
NSPCs; Proliferation; Migration; Differentiation; alpha 4 beta 2 nAChR; ROS
Categories
Funding
- National Natural Science Foundation of China [81270432]
- Polytechnic crossover Foundation of Shanghai Jiao Tong University [AE1700003]
- Shanghai Committee of Science and Technology of China [08431900600]
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Neural stem/progenitor cells (NSPCs) of the subgranular zone have been implicated in cognitive processes, which represent a potentially important source of regenerative medicine for the treatment of neurodegenerative diseases such as Alzheimer's disease (AD). In our previous studies, ZY-1, a novel nicotinic analog, improved cognitive function in transgenic mice model of AD. However, the effect of ZY-1 on the NSPCs remains unclear. Here, we show that ZY-1 significantly increased proliferation and migration of NSPCs, but failed to affect NSPCs differentiation in vitro. Furthermore, during the proliferative period, ZY-1 enhanced intracellular reactive oxygen species (ROS) levels. Meanwhile, ZY-1 also inhibited the levels of A beta(42)-induced ROS. Our data indicate that ZY-1 regulates adult hippocampal neurogenesis in vitro, at least partly due to modulating intracellular ROS levels. These results, taken together with those of our previous studies, suggest that ZY-1 might have a potential therapeutic effect for the treatment of AD.
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