Journal
CELLULAR AND MOLECULAR NEUROBIOLOGY
Volume 33, Issue 1, Pages 69-73Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10571-012-9872-9
Keywords
Simvastatin; Neuroprotection; PC12; Apoptosis; Reactive oxygen species
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Funding
- Shandong Province Natural Science Foundation [ZR2010HL057]
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In the present study, we investigated the neuroprotection of simvastatin in PC12 cells following 1-methyl-4-phenylpyridinium ion (MPP+) neurotoxicity. Simvastatin inhibited the decrease of cell viability induced by MPP+ in PC12 cells. The damage of PC12 cells in morphology was alleviated and the apoptotic rates were decreased due to simvatatin pretreatment against MPP+ cytotoxicity. The reactive oxygen species production exposure to MPP+ was inhibited by simvatatin in PC12 cells. So simvastatin may be of therapeutic benefit for PD patients.
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