Article
Multidisciplinary Sciences
Arie C. van Vliet, Jinhui Lee, Marlijn van der Poel, Matthew R. J. Mason, Jasprina N. Noordermeer, Lee G. Fradkin, Martijn R. Tannemaat, Martijn J. A. Malessy, Joost Verhaagen, Fred De Winter
Summary: The formation of human neuroma-in continuity (NIC) affects functional recovery after peripheral nerve injury, with the role of Wnt ligands in NIC pathology and nerve regeneration attracting interest. Studies have shown the importance of Wnt5a and Wnt receptors in the expression profiles of NIC and injured nerves.
Article
Biochemistry & Molecular Biology
Jinjin Liu, Jinyang An, Na Jiang, Kuan Yang, Conghui Guan, Nan Zhao, Jianguo Cheng, Songbo Fu, Chengxu Ma, Xiaoni Ma, Xulei Tang
Summary: The study found that Codonopsis pilosula polysaccharides (CPPs) can improve osteoporosis in rats by promoting osteogenic differentiation and inhibiting adipogenic differentiation. These results suggest that CPPs may have potential as a preventive and therapeutic agent for osteoporosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Jung Kyu Choi, Ihn-Sil Kwak, Sae-Bom Yoon, Heeyeong Cho, Byoung-San Moon
Summary: CPD0857 has been found to inhibit tumor stem cells in colorectal cancer, reducing proliferation and promoting differentiation, which may serve as a potential drug targeting CSCs.
Article
Neurosciences
Fengyun Zhang, Qiangming Li, Haiying Liang, Yuxia Zhang
Summary: The inhibition of PFK-1 was found to promote neuronal differentiation of neural stem cells and facilitate dendritic maturation of newborn neurons in stroke, improving spatial memory performance, potentially through the promotion of beta-catenin nuclear translocation and activation of downstream signaling pathways independent of Wnt signaling. This suggests that PFK-1 may be a novel target for regenerative repair after stroke.
Review
Cell Biology
Mir Hilal Ahmad, Balaram Ghosh, Moshahid Alam Rizvi, Mansoor Ali, Loveleena Kaur, Amal Chandra Mondal
Summary: Neuroblastoma is a common heterogeneous extracranial cancer in infancy that is associated with aberrant activation of the Wnt signaling pathway. The Wnt signaling pathway regulates the development and differentiation of neural crest cells and affects the proliferation and metastasis of neuroblastoma. Inhibiting the Wnt signaling pathway can induce apoptosis and prevent the occurrence of neuroblastoma.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Oncology
Yinu Wang, Guangyuan Zhao, Salvatore Condello, Hao Huang, Horacio Cardenas, Edward J. Tanner, JianJun Wei, Yanrong Ji, Junjie Li, Yuying Tan, Ramana V. Davuluri, Marcus E. Peter, Ji-Xin Cheng, Daniela Matei
Summary: The study identifies platinum-tolerant cancer cells with cancer stem cell features characterized by expression of FZD7 and dependency on the FZD7-beta-catenin-Tp63-GPX4 pathway for survival. These cells are highly susceptible to ferroptosis, marking a novel therapeutic vulnerability in platinum-resistant cancer cells.
Article
Neurosciences
Hongfei Ge, Chao Zhang, Yang Yang, Weixiang Chen, Jun Zhong, Xuanyu Fang, Xuheng Jiang, Liang Tan, Yongjie Zou, Rong Hu, Yujie Chen, Hua Feng
Summary: The study found that ambroxol therapy enhances functional recovery in ischemic stroke patients by promoting neural stem cells differentiation into neurons and interfering with differentiation into astrocytes, through increasing enzyme glucocerebrosidase expression to activate the Wnt/beta-catenin signaling pathway. These findings advance the understanding of ambroxol in regulating NSCs differentiation and offer a feasible therapy for ischemic stroke treatment and potentially other brain disorders in clinical settings.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Chemistry, Medicinal
Hong-He Xiao, Ming-Bo Zhang, Jun-Ting Xu, Yan Deng, Ning Li, Peng Gao, Yan Li, Liang Kong, Wan-yi Li, Ji-Cong Chen, Hong-Yan Li, Guo-Shun Shan, He Tai, Jing-Xian Yang
Summary: Adult neurogenesis is crucial for cognitive function maintenance in mammals and humans, and it is seen as a potential therapeutic strategy for neurodegenerative diseases like Alzheimer's disease. Icarisid II (ICS II), derived from Epimedii Folium, has been shown to have neuroprotective effects, including promoting proliferation and differentiation of neural stem cells (NSCs). The study demonstrates that ICS II promotes NSCs proliferation and neuronal differentiation by activating the Wnt/beta-catenin signaling pathway.
PHYTOTHERAPY RESEARCH
(2021)
Article
Medicine, Research & Experimental
Min Wang, Hideki Hayashi, Ichiro Horinokita, Mayumi Asada, Yui Iwatani, Jun-guo Ren, Jian-xun Liu, Norio Takagi
Summary: This study examined the effects of senkyunolide I (SEI) on the proliferation and neuronal lineage differentiation of neural stem/progenitor cells (NS/PCs). The results showed that SEI can enhance NS/PC proliferation and suppress their differentiation into neurons and/or astrocytes.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cell & Tissue Engineering
Ming Chen, Hui Han, Siqi Zhou, Yinxian Wen, Liaobin Chen
Summary: This study demonstrates the ability of Morusin to promote osteogenic differentiation of BMSCs through activation of the Wnt/β-catenin signaling pathway, and suggests the potential of Morusin as a treatment for osteoporosis.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Multidisciplinary Sciences
Stella Pearson, Anthony D. Whetton, Andrew Pierce
Summary: Despite advances in precision medicine targeted therapies for cancer, the development of curative treatments remains challenging due to drug resistance in cancer stem cells. Chronic myeloid leukemia is a model for studying cancer stem cells and although targeted therapies have been developed, drug resistance remains a problem. New treatment strategies are needed to target other components within leukemia stem cells, either alone or in combination with existing therapies.
Article
Cell & Tissue Engineering
Pihu Mehrotra, Izuagie Ikhapoh, Pedro Lei, Georgios Tseropoulos, Yali Zhang, Jianmin Wang, Song Liu, Marianne E. Bronner, Stelios T. Andreadis
Summary: Neural crest-like stem cells derived from adult human tissues can maintain their multipotency and enhance their differentiation potential by activating Wnt and BMP signaling and metabolic reprogramming, suggesting potential implications for regenerative medicine.
Article
Geriatrics & Gerontology
Zhenxiong Jin, Weiwei Da, Yongjian Zhao, Tengteng Wang, Hao Xu, Bing Shu, Xiang Gao, Qi Shi, Yong Ma, Yan Zhang, Yongjun Wang, Dezhi Tang
Summary: Osteoporotic fracture (OPF) is a serious complication of osteoporosis. The role of skeletal muscle satellite cells (SMSCs) in promoting OPF healing through beta-catenin has been investigated in this study. The results provide evidence that SMSCs directly contribute to the healing of OPF, which has important clinical implications for the treatment of delayed healing and non-union of OPFs.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Biochemistry & Molecular Biology
Qian Liu, Vsevolod Telezhkin, Wenkai Jiang, Yu Gu, Yan Wang, Wei Hong, Weiming Tian, Polina Yarova, Gaofeng Zhang, Simon Ming-yuen Lee, Peng Zhang, Min Zhao, Nicholas D. Allen, Emilio Hirsch, Josef Penninger, Bing Song
Summary: Neural stem cells have the potential for cell replacement therapy, but their tendency to differentiate into glial rather than neuronal phenotypes limits positive outcomes. Physiological electric field (EF) stimulation can boost the neuronal differentiation of neural stem cells without extra chemical side effects, providing a safe and efficient cell therapy for neurological recovery.
CELL AND BIOSCIENCE
(2023)
Article
Multidisciplinary Sciences
Dustin J. Flanagan, Nalle Pentinmikko, Kalle Luopajarvi, Nicky J. Willis, Kathryn Gilroy, Alexander P. Raven, Lynn Mcgarry, Johanna Englund, Anna T. Webb, Sandra Scharaw, Nadia Nasreddin, Michael C. Hodder, Rachel A. Ridgway, Emma Minnee, Nathalie Sphyris, Ella Gilchrist, Arafath K. Najumudeen, Beatrice Romagnolo, Christine Perret, Ann C. Williams, Hans Clevers, Pirjo Nummela, Marianne Lahde, Kari Alitalo, Ville Hietakangas, Ann Hedley, William Clark, Colin Nixon, Kristina Kirschner, E. Yvonne Jones, Ari Ristimaki, Simon J. Leedham, Paul Fish, Jean-Paul Vincent, Pekka Katajisto, Owen J. Sansom
Summary: The tumour suppressor APC is the most commonly mutated gene in colorectal cancer. Loss of Apc in intestinal stem cells drives the formation of adenomas in mice via increased WNT signalling, while reduced secretion of WNT ligands increases the ability of Apc-mutant intestinal stem cells to colonize a crypt. The study found that Apc-mutant cells are enriched for transcripts encoding several secreted WNT antagonists, with Notum being the most highly expressed. These cells actively inhibit the proliferation of surrounding wild-type crypt cells, outcompeting them in the niche and driving their differentiation.