Article
Behavioral Sciences
Zinaida I. Storozheva, Elena I. Zakharova, Andrey T. Proshin
Summary: This study aimed to evaluate the association of ChAT activity in the neocortex and hippocampus with spatial learning using the Morris water maze. The results suggest different roles of ChAT activity in different stages of memory formation. Further evaluation of other signaling pathways at these stages is recommended.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Neurosciences
Keyvan Mehri, Zohreh Zavvari Oskuye, Ehsan Nassireslami, Esmail Karami, Mohammad Reza Parvizi
Summary: This study investigated the effects of Botulinum toxin on spatial memory and biochemical and histological parameters in the hippocampus of male rats. Results showed that Botox significantly impaired memory performance and led to a decrease in acetylcholine levels, increase in acetylcholinesterase activity, and morphological damage in the hippocampus. Administration of Rivastigmine partially alleviated these effects and could serve as a protective approach.
Article
Biochemistry & Molecular Biology
Jagadeesh Dhamodharan, Ganthimathy Sekhar, Arunachalam Muthuraman
Summary: This study aimed to explore the ameliorative potential of gefitinib (GE) in Alzheimer's disease (AD) mice. The results showed that GE significantly improved AD-associated behavioral, biochemical, and histopathological changes by inhibiting EGFR kinase activation and having antioxidant and antilipid peroxidative effects against A beta(1-42) oligomer-induced neurotoxicity.
Article
Biochemistry & Molecular Biology
Muhammad Afzal, Sami Alzarea, Khalid Saad Alharbi, Abdulaziz Alzarea, Sattam Khulaif Alenezi, Mohammed Salem Alshammari, Ali H. Alquraini, Imran Kazmi
Summary: The aim of this study was to determine whether rosiridin, a bioactive component of Rhodiola rosea, could protect rats from neurocognitive problems induced by scopolamine. The results showed that rosiridin improved behavioral parameters, reduced oxidative stress and inflammation markers, restored acetylcholine esterase and choline acetyltransferase activities, and normalized other biochemical parameters. These findings suggest that rosiridin may limit the effects of scopolamine on rat cognitive function.
Article
Neurosciences
Hemant Kumar, Jatinder Katyal, Yogendra Kumar Gupta
Summary: This study demonstrates the therapeutic effects of the KOR agonist U50488 on SE and its beneficial effects on SE-related mortality and memory impairment in a rat lithium-pilocarpine SE model.
NEUROSCIENCE LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Khian Giap Lim, Rajavel Varatharajan, Arunachalam Muthuraman
Summary: This study investigated the beneficial effects of beta-carotene on diabetes-associated vascular dementia and its antioxidative actions. Beta-carotene treatment improved cognitive function and reduced oxidative stress markers in rats with diabetic vascular dementia.
Article
Neurosciences
Lisa Wintzell, Samuel Klemetz, Stefan Lange, Eric Hanse, Caroline Wass, Joakim Strandberg
Summary: The endogenous peptide antisecretory factor (AF) enhances long-term potentiation (LTP) and spatial learning and memory by disinhibiting GABAergic transmission in the rat hippocampus.
Article
Behavioral Sciences
Amanda Dyer, Maxine De Butte
Summary: This study aimed to examine the effects of chronic low-dose vanadium administration on the behavior of young male rats. The findings suggest that vanadium does not significantly affect exploration, locomotion, or anxiety-like behavior in rats, but does affect novel object recognition performance. Additionally, vanadium administration led to lower latency times in the Morris Water maze task.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Endocrinology & Metabolism
Maryam Sajjadi, Ehsan Oskoueian, Ehsan Karimi, Mahdi Ebrahimi
Summary: The root extract of Amygdalus spinosissima plant contains bioactive phenolic and flavonoid compounds with antioxidant and anti-inflammatory properties, improving learning and memory function in mice. This extract shows promising potential in retarding the development of neurodegenerative diseases such as Alzheimer's disease.
METABOLIC BRAIN DISEASE
(2021)
Article
Behavioral Sciences
Ewa Zwierzynska, Boguslawa Pietrzak
Summary: Lacosamide does not impair memory and learning processes, with temporary disruption of emotional memory observed only after a single high dose administration.
EPILEPSY & BEHAVIOR
(2021)
Article
Medicine, Research & Experimental
Fateme Khodabande, Esmaeil Akbari, Motahareh Rouhi Ardeshiri
Summary: The orexin 1 receptors in the dorsal raphe nucleus play a significant role in the consolidation of spatial reference memory in rats, while the orexin 2 receptors do not have an effect.
Article
Neurosciences
Jemi Feiona Vergil Andrews, Divya Bharathi Selvaraj, Akshay Kumar, Syed Aasish Roshan, Muthuswamy Anusuyadevi, Mahesh Kandasamy
Summary: This study investigated the effect of aspirin on spatial memory in ageing experimental mice. Aspirin was found to enhance working memory, increase the number of new neurons in the hippocampus, reduce the number of microglial cells, and decrease the activity of AChE in the blood.
Article
Medicine, Research & Experimental
Yu Wang, Kai Chen, Zi-xuan Qiao, Xiao-rong Bao
Summary: This study investigates the progression of cognitive impairment induced by CKD and the involvement of cognition-related proteins in Sprague-Dawley rats. The results show that CKD patients exhibit cognitive dysfunction and downregulation of cognition-related proteins.
CURRENT MEDICAL SCIENCE
(2023)
Review
Behavioral Sciences
Lucia Amendola, Daniel Weary, Gosia Zobel
Summary: Individual variation in responses to anxiety and spatial memory tests is often reported. These variations are related to consistent individual differences in behavior (personality). However, personality differences are rarely considered in anxiety treatment studies. This article focuses on rat literature to describe principles in anxiety and spatial memory tests and discusses the influence of personality and housing conditions on behavioral responses. The authors propose that environmental enrichment can enhance stress resiliency in environmentally sensitive individuals. Incorporating personality measures into study design and analysis can improve research reproducibility.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Pharmacology & Pharmacy
Burak Tan, Umut Bakkaloglu, Meral Ascioglu, Cem Suer
Summary: This study found that thyroid hormone excessiveness during perinatal period can lead to long-lasting effects on hippocampal function, with differences in behavior and molecular indicators between rats treated with l-thyroxine during maternal period and in young adulthood. These effects may contribute to memory problems observed in adolescents with lactational hyperthyroidism.
PHARMACOLOGICAL REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Soane K. M. Chaves, Chistiane M. Feitosa, Lidiane da S. Araujo
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Jessica P. Costa, Md. T. Islam, Pauline S. Santos, Paula B. Ferreira, George L. S. Oliveira, Marcus V. O. B. Alencar, Marcia F. C. J. Paz, Everton L. F. Ferreira, Chistiane M. Feitosa, Antonia M. G. L. Cito, Damiao P. Sousa, Ana Amelia C. Melo-Cavalcante
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2016)
Article
Chemistry, Multidisciplinary
Adonias Almeida Carvalho, Lucivania Rodrigues dos Santos, Ruth Raquel Soares de Farias, Mariana Helena Chaves, Chistiane Mendes Feitosa, Gerardo Magela Vieira Junior, Monica Regina Silva de Araujo, Paulo Michel Pinheiro Ferreira, Claudia do O. Pessoa
Article
Medicine, Legal
George Laylson da Silva Oliveira, Keylla Conceicao Machado, Katia Conceicao Machado, Ana Paula dos Santos C. L. da Silva, Chistiane Mendes Feitosa, Fernanda Regina de Castro Almeida
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2018)
Article
Pharmacology & Pharmacy
Joaquim S. Costa Junior, Alexandre B. F. Ferraz, Taciana O. Sousa, Romezio A. C. Silva, Sidney G. De Lima, Chistiane M. Feitosa, Antonia M. G. L. Cito, Ana A. C. Melo Cavalcante, Rivelilson M. Freitas, Angelo R. Moura Sperotto, Valeria F. Peres, Dinara J. Moura, Jenifer Saffi
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2013)
Article
Chemistry, Physical
Antonio do Nascimento Cavalcante, Chistiane Mendes Feitosa, Felipe Pereira da Silva Santos, Ana Paula Rodrigues de Sousa, Ronaldo dos Santos Sousa Junior, Alexandre Araujo de Souza, Bernardo Ferreira Pinto, Cristiany Marinho Araujo, Khaled Rashed
JOURNAL OF MOLECULAR STRUCTURE
(2019)
Article
Chemistry, Multidisciplinary
Rusbene Bruno Fonseca de Carvalho, Antonia Amanda Cardoso de Almeida, Rivelilson Mendes de Freitas, Luciano Silva Lima, Juceni Pereira David, Jorge Mauricio David, Chistiane Mendes Feitosa
Review
Biotechnology & Applied Microbiology
Layana Karine F. Lima, Suyanne Kassia S. Pereira, Ronaldo dos Santos S. Junior, Felipe Pereira da S. Santos, Alyandra de Sousa Nascimento, Chistiane Mendes Feitosa, Juliana de Sousa Figueredo, Antonio do Nascimento Cavalcante, Edigenia Cavalcante da C. Araujo, Mahendra Rai
BIOMED RESEARCH INTERNATIONAL
(2018)
Article
Environmental Sciences
Patricia e Silva Alves, Maria das Dores Alves de Oliveira, Pedro Marcos de Almeida, Francielle Aline Martins, Ana Amelia de Carvalho Melo Cavalcante, Teresinha de Jesus Aguiar dos Santos Andrade, Chistiane Mendes Feitosa, Mahendra Rai, Antonielly Campinho dos Reis, Joaquim Soares da Costa Junior
Article
Biotechnology & Applied Microbiology
Avinash P. Ingle, Shweta Wagh, Jayantakumar Biswas, Monojit Mondal, Chistiane Mendes Feitosa, Mahendra Rai
CURRENT NANOSCIENCE
(2020)
Article
Toxicology
Antonio do Nascimento Cavalcante, Layana Karine Farias Lima, Cristiany Marinho Araujo, Felipe Pereira da Silva Santos, Matheus Oliveira do Nascimento, Joao Marcelo de Castro e Sousa, Mahendra Rai, Chistiane Mendes Feitosa
TOXICOLOGY REPORTS
(2020)
Article
Plant Sciences
C. M. Feitosa, M. F. K. Cardoso, L. S. G. Oliveira, J. Figueredo, C. H. S. Melo, K. Rashed
INDIAN JOURNAL OF NATURAL PRODUCTS AND RESOURCES
(2020)
Article
Biochemistry & Molecular Biology
Soane Kaline Morais Chaves, Muhammad Inam Afzal, Muhammad Torequl Islam, Aneela Hameed, Ana Maria Oliveira Ferreira da Mata, Lidiane da Silva Araujo, Shinawar Waseem Ali, Hercilia Maria Lins Rolim, Maria das Gracas Freire de Medeiros, Emmanoel Vilaca Costa, Bahare Salehi, Natalia Martins, Atta Muhammad Arif, Muhammad Imran, Javad Sharifi-Rad, Ana Amelia de Carvalho Melo-Cavalcante, Chistiane Mendes Feitosa
CELLULAR AND MOLECULAR BIOLOGY
(2020)
Meeting Abstract
Public, Environmental & Occupational Health
Udia Cardinalle Lima Teixeira, Antonia Maria das Gracas Lopes Cito, Danilo de Oliveira Ribeiro, Francisca Maria Macedo Pereira, Fernanda Sousa Reinaldo, Iolanda Souza do Carmo, Lorenna Fonseca, Alek Andre Costa de Sousa, Arkellau Kenned Silva Moura, Chistiane Mendes Feitosa, Juliana de Sousa Figueredo, Lydia Masako Ferreira, Lis Cardoso Marinho Medeiros
JOURNAL OF WOMENS HEALTH
(2019)
Review
Pharmacology & Pharmacy
Chistiane Mendes Feitosa, George Laylson da Silva Oliveira, Antonio do Nascimento Cavalcante, Soane Kaline Morais Chaves, Mahendra Rai
CURRENT CLINICAL PHARMACOLOGY
(2018)