Article
Medicine, Research & Experimental
Weizhong Ji, Yaqing Zhang, Junming Luo, Yaqi Wan, Jie Liu, Ri-Li Ge
Summary: The study suggests that chronic hypoxia can lead to excitatory toxicity causing neural injury and cognitive impairment, which can be alleviated by memantine treatment. This is evidenced by changes in NMDA and AMPA receptor expression, increased neuronal cell death and oxidative stress after 4 weeks of hypoxia exposure, and improved cognitive function after memantine treatment.
Article
Biochemistry & Molecular Biology
Gaoping Lin, Feiyan Zhu, Nicholas M. Kanaan, Rei Asano, Norimichi Shirafuji, Hirohito Sasaki, Tomohisa Yamaguchi, Soichi Enomoto, Yoshinori Endo, Asako Ueno, Masamichi Ikawa, Kouji Hayashi, Osamu Yamamura, Shu-Hui Yen, Yasunari Nakamoto, Tadanori Hamano
Summary: The neuropathological features of Alzheimer's disease are senile plaques and neurofibrillary tangles, which are composed of amyloid beta protein and phosphorylated tau protein respectively. Metal regulation, especially with compounds like clioquinol, may be a potential direction for AD treatment. Clioquinol has been shown to decrease metal accumulation, tau phosphorylation, and activate pathways involved in tau protein degradation, potentially offering new insights into AD therapeutics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Mathematics
Jin-Jian Hsieh, Cheng-Chih Hsieh
Summary: This paper discusses parameter estimation in the quantile regression model for dependent truncated data. The Archimedean copula model is used to account for the dependence between survival time and truncated time. The parameters of the Archimedean copula model are estimated using existing approaches, and a weighted inference procedure is proposed based on the variables of interest in the quantile regression model. The proposed approach is evaluated through simulations and applied to analyze real datasets.
Article
Multidisciplinary Sciences
Zhen-Kai Ngian, Yow-Yong Tan, Ching-Thong Choo, Wei-Qi Lin, Chao-Yong Leow, Shan-Jie Mah, Mitchell Kim-Peng Lai, Christopher Li-Hsian Chen, Chin-Tong Ong
Summary: The retention of intron 11 of the Tau gene in Alzheimer's disease (AD) leads to the production of truncated Tau11i protein, which is enriched in the brains of AD patients and exhibits biochemical properties resembling pathological Tau species. Therefore, the retention of intron 11 of the Tau gene might be an early biomarker of AD pathology.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Yang Gao, Yuying Wang, Huiyang Lei, Zhendong Xu, Shihong Li, Haitao Yu, Jiazhao Xie, Zhentao Zhang, Gongping Liu, Yao Zhang, Jie Zheng, Jian-Zhi Wang
Summary: This study developed an easy-to-use tool for drug development and investigations of Alzheimer's disease and other tauopathies. A new mouse model was generated that mimics the exclusive neuronal tau pathologies of AD.
TRANSLATIONAL NEURODEGENERATION
(2023)
Article
Biochemistry & Molecular Biology
Olayemi Joseph Olajide, Ismail Tayo Gbadamosi, Emmanuel Olusola Yawson, Tolulope Arogundade, Folashade Susan Lewu, Kehinde Yomi Ogunrinola, Oluwaseun Olaniyi Adigun, Olawande Bamisi, Ezra Lambe, Leviticus Ogbenevurinrin Arietarhire, Olushola Oladapo Oluyomi, Olumayowa Kolawole Idowu, Rukayat Kareem, Nnaemeka Tobechukwu Asogwa, Philip Adeyemi Adeniyi
Summary: The study investigated the acute effects of glutamate injection on behavior and molecular expression in the dentate gyrus, showing that glutamate induced anxiogenic responses and spatial memory impairments, which were inhibited by the NMDAR antagonist memantine.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Michael G. Friedrich, Amanda Skora, Sarah E. Hancock, Todd W. Mitchell, Paul L. Else, Roger J. W. Truscott
Summary: Tau truncation is prevalent in the normal human brain, with fragments of Tau of different sizes and structures found across different brain regions. This phenomenon is observed as early as 18 years old, suggesting a potential role of Tau cleavage in brain development and aging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Longfei Li, Yanli Jiang, Gang Wu, Yacoubou Abdoul Razak Mahaman, Dan Ke, Qun Wang, Bin Zhang, Jian-Zhi Wang, Hong-Lian Li, Rong Liu, Xiaochuan Wang
Summary: Abnormal posttranslational modifications of tau, including phosphorylation and truncation, play important roles in tau pathology and neurodegeneration. Phosphorylation of truncated tau significantly fosters endogenous tau pathology and neurodegeneration.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Chemistry, Physical
Wei Zhang, Nabin Kandel, Yiqun Zhou, Nathan Smith, Braulio C. L. B. Ferreira, Miranda Perez, Matteo L. Claure, Keenan J. Mintz, Chunyu Wang, Roger M. Leblanc
Summary: This study explored the efficacy of two types of carbon dots as nano-carriers for Alzheimer's disease therapy. The carbon dots successfully inhibited the aggregation of tau protein, demonstrating their potential for drug delivery in Alzheimer's treatment. These findings have significant implications for enhancing the delivery of drugs to target Alzheimer's pathology in the brain.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Ekaterina V. Pershina, Irina Yu. Chernomorets, Dmitry A. Fedorov, Vladimir I. Arkhipov
Summary: In this study, the neuroprotective properties of the combination of memantine, a non-competitive NMDA receptor antagonist, and VU 0422288, a positive allosteric modulator of metabotropic glutamate receptors, were investigated. The results showed that the combined use of memantine and VU 0422288 significantly reduced neuronal cell death in the CA1 region of the hippocampus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Chong Sun, Xin-Cheng Cao, Zhi-Yang Liu, Chao-Lin Ma, Bao-Ming Li
Summary: Excessive extracellular glutamate can lead to excitotoxicity and neuronal death through NMDARs overactivation. Polygalasaponin F (PGSF) can protect hippocampal neurons from glutamate-induced cytotoxicity by regulating NMDARs.
NEURAL REGENERATION RESEARCH
(2022)
Article
Neurosciences
Carola Tapia-Monsalves, Margrethe A. Olesen, Francisca Villavicencio-Tejo, Rodrigo A. Quintanilla
Summary: During Alzheimer's, abnormal post-translational modifications of tau protein, such as cleaving by caspase-3, contribute to cognitive decline and impair synaptic plasticity. Additionally, caspase-3 cleaved tau impairs mitochondrial function and organelle transport, both important for synapse. The absence of tau expression can reverse age-associated cognitive and mitochondrial failure by blocking the mitochondrial permeability transition pore (mPTP). Understanding the effects of TauC3 on synaptic elements and the role of mPTP can provide insights into Alzheimer's disease progression.
MOLECULAR AND CELLULAR NEUROSCIENCE
(2023)
Letter
Medicine, General & Internal
Dae Hyun Kim, Xihao Li, Shijia Bian, Lee-Jen Wei, Ryan Sun
Summary: This cohort study examines the usefulness of restricted mean survival time as a method for measuring the time to nursing home placement among patients with dementia.
Review
Neurosciences
Shan P. Yu, Michael Q. Jiang, Seong S. Shim, Soheila Pourkhodadad, Ling Wei
Summary: Stroke and late-onset Alzheimer's disease (AD) are risk factors for each other. The similarities and differences between the two in terms of pathogenesis and pathophysiology have rarely been reviewed. Recent research has found that the activation of NMDA receptors and the resulting calcium influx play an important role in both stroke and AD. Blocking extrasynaptic NMDA receptors with drugs like memantine could serve as a potential treatment option for both diseases.
MOLECULAR NEURODEGENERATION
(2023)
Article
Neurosciences
Valentina Latina, Giacomo Giacovazzo, Federica Cordella, Bijorn Omar Balzamino, Alessandra Micera, Monica Varano, Cristina Marchetti, Francesca Malerba, Rita Florio, Bruno Bruni Ercole, Federico La Regina, Anna Atlante, Roberto Coccurello, Silvia Di Angelantonio, Pietro Calissano, Giuseppina Amadoro
Summary: The retina and optic nerve are sites of extra-cerebral manifestations of Alzheimer's Disease, with tau protein truncation leading to pathological changes and administration of the specific 12A12mAb showing beneficial effects on ocular injury. This research opens new avenues for the clinical management of cerebral and extracerebral AD signs by targeting tau protein modifications and their neuroprotective actions.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Article
Cell Biology
Martin Cente, Stefan Zorad, Tomas Smolek, Lubica Fialova, Natalia Paulenka Ivanovova, Katarina Krskova, Lucia Balazova, Rostislav Skrabana, Peter Filipcik
Summary: The close relationship between Alzheimer's disease and obesity, mediated by the key adipokine leptin, was investigated in rat transgenic model. The study found decreased levels of plasma leptin and body weight, as well as a correlation between neurofibrillary pathology and leptin levels. The data suggests that plasma leptin could serve as a convenient biomarker for tauopathies and Alzheimer's disease.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Review
Neuroimaging
Inga K. Koerte, Roald Bahr, Peter Filipcik, Jolien Gooijers, Alexander Leemans, Alexander P. Lin, Yorghos Tripodis, Martha E. Shenton, Nir Sochen, Stephan P. Swinnen, Ofer Pasternak
Summary: The study focuses on the impacts of repetitive head impacts on the brain structure and function of youth athletes, as well as potential clinical or behavioral consequences. Through the REPIMPACT Consortium, a multinational research effort aims to comprehensively assess competitive soccer players exposed to repetitive head impacts by providing complex molecular-level data.
BRAIN IMAGING AND BEHAVIOR
(2022)
Article
Neurosciences
Stian Bahr Sandmo, Katarina Matyasova, Peter Filipcik, Martin Cente, Inga Katharina Koerte, Ofer Pasternak, Thor Einar Andersen, Truls Martin Straume-Naesheim, Roald Bahr, Igor Jurisica
Summary: This study aimed to investigate the short-term effects of accidental head impacts and repetitive headers on circulating microRNAs, while taking into account the effects of high-intensity exercise alone. The results identified specific microRNAs associated with accidental head impacts and repetitive headers, suggesting their potential as biomarkers for brain injury.
Article
Medicine, General & Internal
Branislav Kovacech, Lubica Fialova, Peter Filipcik, Rostislav Skrabana, Monika Zilkova, Natalia Paulenka-Ivanovova, Andrej Kovac, Denisa Palova, Gabriela Paulikova Rolkova, Katarina Tomkova, Natalia Turic Csokova, Karina Markova, Michaela Skrabanova, Kristina Sinska, Neha Basheer, Petra Majerova, Jozef Hanes, Vojtech Parrak, Michal Prcina, Ondrej Cehlar, Martin Cente, Juraj Piestansky, Michal Fresser, Michal Novak, Monika Slavikova, Kristina Borsova, Viktoria Cabanova, Bronislava Brejova, Tomas Vinar, Jozef Nosek, Boris Klempa, Ludek Eyer, Vaclav Honig, Martin Palus, Daniel Ruzek, Tereza Vyhlidalova, Petra Strakova, Blanka Mrazkova, Dagmar Zudova, Gizela Koubkova, Vendula Novosadova, Jan Prochazka, Radislav Sedlacek, Norbert Zilka, Eva Kontsekova
Summary: This study developed second-generation antibodies using hybridoma technology, ELISA-based assays, and authentic virus neutralization assays to target new variants of concern of SARS-CoV-2. AX290 and AX677 showed excellent neutralizing capabilities against various SARS-CoV-2 variants, reducing viral burden and inflammation in the lungs, and preventing disease in a mouse model of infection.
Review
Cell Biology
Martin Cente, Katarina Matyasova, Nikoleta Csicsatkova, Adela Tomikova, Sara Porubska, Yun Niu, Marek Majdan, Peter Filipcik, Igor Jurisica
Summary: The history of traumatic brain injury (TBI) is a significant risk factor for the development of dementia and neurodegenerative disorders in later life. By analyzing peripheral blood microRNAs, this study identified genes, proteins, and pathways connected to neurodegenerative cascades following severe TBI. These findings have implications for potential therapeutic targets and biomarkers.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Medicine, General & Internal
Martin Cente, Janka Perackova, Pavol Peracek, Marek Majdan, Igor Toth, Martin Mikulic, Jozef Hanes, Sara Porubska, Marian Spajdel, Barbora Kazickova, Igor Jurisica, Peter Filipcik
Summary: This study investigates the dynamics of phosphorylated tau protein (p-tau(181)) levels and the ratio of p-tau(181) to total tau in individuals after nonconcussive head impacts. The results show that intense physical activity and repetitive head impacts lead to elevated levels of total tau and p-tau(181) in plasma, as well as negative impacts on attention and cognitive flexibility.
Article
Biochemistry & Molecular Biology
Marek Majdan, Igor Toth, Patrik Barila, Pavol Peracek, Janka Perackova, Silvio Parnican, Martin Cente, Peter Filipcik
Summary: This study estimated the incidence of head impacts in youth ice-hockey leagues in Slovakia using official game statistics, finding varying incidence rates between the U18 and U20 leagues, as well as higher rates in later periods of games. The study calls for immediate measures to prevent these injuries.
GENERAL PHYSIOLOGY AND BIOPHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Katarina Matyasova, Nikoleta Csicsatkova, Peter Filipcik, Igor Jurisica, Martin Cente
Summary: Through comprehensive analysis of miRNAs, we have identified genes and signaling pathways associated with mild TBI, as well as a group of potential novel candidate targets. These findings provide us with a more comprehensive understanding of the molecular events following mild TBI.
GENERAL PHYSIOLOGY AND BIOPHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Martin Cente, Tomas Smolek, Stefan Zorad, Lubica Fialova, Natalia Paulenka Ivanovova, Katarina Krskova, Lucia Balazova, Rostislav Skrabana, Peter Filipcik
Summary: Neurodegeneration is associated with hypertension and disturbance in fat metabolism, but the complex interaction of these processes is not fully understood. Induced tauopathy in hypertensive transgenic animals leads to significant downregulation of plasma leptin and various metabolic changes, while not affecting the leptin signaling pathway.
GENERAL PHYSIOLOGY AND BIOPHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Nikoleta Csicsatkova, Peter Szalay, Katarina Matyasova, Veronika Mate, Martin Cente, Tomas Smolek, Veronika Brezovakova, Lucie Kawecka, Norbert Zilka, Santosh Jadhav
Summary: This study is the first to investigate the transcriptomic profile of AD-Tau seed-induced pathology in the hippocampus of a transgenic tauopathy model. The research identified molecular changes and inflammatory signaling pathways, as well as pathways related to autophagy and endoplasmic reticulum stress that may play crucial roles in the induction and propagation of tau pathology.
GENERAL PHYSIOLOGY AND BIOPHYSICS
(2021)