EGFR-dependent mechanisms in glioblastoma: towards a better therapeutic strategy

The NFκB pathway: a therapeutic target in glioblastoma

(2015) Lorena Nogueira et al.   Oncotarget

Pyruvate kinase M2 regulates glucose metabolism by functioning as a coactivator for hypoxia-inducible factor 1 in cancer cells

(2015) Weibo Luo et al.   Oncotarget

Epidermal Growth Factor Receptor in Glioma: Signal Transduction, Neuropathology, Imaging, and Radioresistance

(2015) Kimmo J. Hatanpaa et al.   NEOPLASIA

Mitochondrially localized EGFR is subjected to autophagic regulation and implicated in cell survival

(2014) Xiaojing Yue et al.   Autophagy

Gambogic acid induces EGFR degradation and Akt/mTORC1 inhibition through AMPK dependent-LRIG1 upregulation in cultured U87 glioma cells

(2013) Xin-yao He et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

EGFR Phosphorylates Tumor-Derived EGFRvIII Driving STAT3/5 and Progression in Glioblastoma

(2013) Qi-Wen Fan et al.   CANCER CELL

Phosphorylation of EZH2 Activates STAT3 Signaling via STAT3 Methylation and Promotes Tumorigenicity of Glioblastoma Stem-like Cells

(2013) Eunhee Kim et al.   CANCER CELL

Mesenchymal Differentiation Mediated by NF-κB Promotes Radiation Resistance in Glioblastoma

(2013) Krishna P.L. Bhat et al.   CANCER CELL

Caveolin-1 is a negative regulator of tumor growth in glioblastoma and modulates chemosensitivity to temozolomide

(2013) Kevin Quann et al.   CELL CYCLE

Cellular Functions Regulated by Phosphorylation of EGFR on Tyr845

(2013) Ken-ichi Sato   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inhibition of DYRK1A destabilizes EGFR and reduces EGFR-dependent glioblastoma growth

(2013) Natividad Pozo et al.   JOURNAL OF CLINICAL INVESTIGATION

The integrated landscape of driver genomic alterations in glioblastoma

(2013) Veronique Frattini et al.   NATURE GENETICS

Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptake

(2013) William A Flavahan et al.   NATURE NEUROSCIENCE

The soluble form of the tumor suppressor Lrig1 potently inhibits in vivo glioma growth irrespective of EGF receptor status

(2013) Mikael Johansson et al.   NEURO-ONCOLOGY

Combined RNAi-Mediated Suppression of Rictor and EGFR Resulted in Complete Tumor Regression in an Orthotopic Glioblastoma Tumor Model

(2013) Maite Verreault et al.   PLoS One

Pyruvate Kinase M2 Expression, but Not Pyruvate Kinase Activity, Is Up-Regulated in a Grade-Specific Manner in Human Glioma

(2013) Joydeep Mukherjee et al.   PLoS One

The Relative Expression of Mig6 and EGFR Is Associated with Resistance to EGFR Kinase Inhibitors

(2013) Xiaofei Chang et al.   PLoS One

Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3

(2013) P. Mao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EGFR-SGLT1 interaction does not respond to EGFR modulators, but inhibition of SGLT1 sensitizes prostate cancer cells to EGFR tyrosine kinase inhibitors

(2013) Jiangong Ren et al.   PROSTATE

EGFR cooperates with glucose transporter SGLT1 to enable chromatin remodeling in response to ionizing radiation

(2013) Klaus Dittmann et al.   RADIOTHERAPY AND ONCOLOGY

De-Repression of PDGFRβ Transcription Promotes Acquired Resistance to EGFR Tyrosine Kinase Inhibitors in Glioblastoma Patients

(2013) David Akhavan et al.   Cancer Discovery

Opposing Effect of EGFRWT on EGFRvIII-Mediated NF-κB Activation with RIP1 as a Cell Death Switch

(2013) Vineshkumar Thidil Puliyappadamba et al.   Cell Reports

Landscape of EGFR signaling network in human cancers: Biology and therapeutic response in relation to receptor subcellular locations

(2012) Woody Han et al.   CANCER LETTERS

The MET Oncogene Is a Functional Marker of a Glioblastoma Stem Cell Subtype

(2012) F. De Bacco et al.   CANCER RESEARCH

The Definition of Primary and Secondary Glioblastoma

(2012) H. Ohgaki et al.   CLINICAL CANCER RESEARCH

Epidermal growth factor receptor

(2012) Monika E. Hegi et al.   CURRENT OPINION IN NEUROLOGY

Nimotuzumab treatment of malignant gliomas

(2012) Udo Bode et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Emerging insights into the molecular and cellular basis of glioblastoma

(2012) G. P. Dunn et al.   GENES & DEVELOPMENT

The role of STAT3 activation in modulating the immune microenvironment of GBM

(2012) Alfred P. See et al.   JOURNAL OF NEURO-ONCOLOGY

EGFR-Induced and PKCε Monoubiquitylation-Dependent NF-κB Activation Upregulates PKM2 Expression and Promotes Tumorigenesis

(2012) Weiwei Yang et al.   MOLECULAR CELL

A phase I/II trial of vandetanib for patients with recurrent malignant glioma

(2012) T. N. Kreisl et al.   NEURO-ONCOLOGY

Caveolin-1, caveolae, and glioblastoma

(2012) M.-O. Parat et al.   NEURO-ONCOLOGY

Potential Role for STAT3 Inhibitors in Glioblastoma

(2012) Christopher Jackson et al.   NEUROSURGERY CLINICS OF NORTH AMERICA

Evaluation of Tyrosine Kinase Inhibitor Combinations for Glioblastoma Therapy

(2012) Avadhut D. Joshi et al.   PLoS One

Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240

(2012) T. R. Fenton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response

(2012) N. J. Szerlip et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia promotes ligand-independent EGF receptor signaling via hypoxia-inducible factor-mediated upregulation of caveolin-1

(2012) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EGFR-mediated stimulation of sodium/glucose cotransport promotes survival of irradiated human A549 lung adenocarcinoma cells

(2012) Stephan M. Huber et al.   RADIOTHERAPY AND ONCOLOGY

Rocking cell metabolism: revised functions of the key glycolytic regulator PKM2 in cancer

(2012) Barbara Chaneton et al.   TRENDS IN BIOCHEMICAL SCIENCES

Emerging roles of PKM2 in cell metabolism and cancer progression

(2012) Weibo Luo et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Kinetics of Inhibitor Cycling Underlie Therapeutic Disparities between EGFR-Driven Lung and Brain Cancers

(2012) Krister J. Barkovich et al.   Cancer Discovery

Differential Sensitivity of Glioma- versus Lung Cancer–Specific EGFR Mutations to EGFR Kinase Inhibitors

(2012) Igor Vivanco et al.   Cancer Discovery

Epidermal growth factor receptor mutation in combination with expression of MIG6 alters gefitinib sensitivity

(2011) Yoshimi Naruo et al.   BMC Systems Biology

Src family kinases mediate epidermal growth factor receptor signaling from lipid rafts in breast cancer cells

(2011) Mary E. Irwin et al.   CANCER BIOLOGY & THERAPY

Mosaic Amplification of Multiple Receptor Tyrosine Kinase Genes in Glioblastoma

(2011) Matija Snuderl et al.   CANCER CELL

Chronic Activation of Wild-Type Epidermal Growth Factor Receptor and Loss of Cdkn2a Cause Mouse Glioblastoma Formation

(2011) J. Acquaviva et al.   CANCER RESEARCH

DNA Damage Response and Growth Factor Signaling Pathways in Gliomagenesis and Therapeutic Resistance

(2011) M. Squatrito et al.   CANCER RESEARCH

Amphiregulin Exosomes Increase Cancer Cell Invasion

(2011) James N. Higginbotham et al.   CURRENT BIOLOGY

Regulation of the catalytic activity of the EGF receptor

(2011) Nicholas F Endres et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Molecular subclassification of diffuse gliomas: Seeing order in the chaos

(2011) Jason T. Huse et al.   GLIA

Nuclear Translocation of Epidermal Growth Factor Receptor by Akt-dependent Phosphorylation Enhances Breast Cancer-resistant Protein Expression in Gefitinib-resistant Cells

(2011) Wei-Chien Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of Src induces mitochondrial localisation of de2-7EGFR (EGFRvIII) in glioma cells: implications for glucose metabolism

(2011) Anna N. Cvrljevic et al.   JOURNAL OF CELL SCIENCE

Analysis of Phosphotyrosine Signaling in Glioblastoma Identifies STAT5 as a Novel Downstream Target of ΔEGFR

(2011) Vaibhav Chumbalkar et al.   JOURNAL OF PROTEOME RESEARCH

EGFR and EGFRvIII undergo stress- and EGFR kinase inhibitor-induced mitochondrial translocalization: A potential mechanism of EGFR-driven antagonism of apoptosis

(2011) Xinyu Cao et al.   Molecular Cancer

Pathway Analysis of Glioblastoma Tissue after Preoperative Treatment with the EGFR Tyrosine Kinase Inhibitor Gefitinib--A Phase II Trial

(2011) M. E. Hegi et al.   MOLECULAR CANCER THERAPEUTICS

FAS and NF-κB signalling modulate dependence of lung cancers on mutant EGFR

(2011) Trever G. Bivona et al.   NATURE

Feedback regulation of EGFR signalling: decision making by early and delayed loops

(2011) Roi Avraham et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Integration and analysis of genome-scale data from gliomas

(2011) Gregory Riddick et al.   Nature Reviews Neurology

A phase II trial of erlotinib in patients with recurrent malignant gliomas and nonprogressive glioblastoma multiforme postradiation therapy

(2011) J. J. Raizer et al.   NEURO-ONCOLOGY

Coexpression of SGLT1 and EGFR is associated with tumor differentiation in oral squamous cell carcinoma

(2011) Yasuko Hanabata et al.   Odontology

Acquired MET expression confers resistance to EGFR inhibition in a mouse model of glioblastoma multiforme

(2011) H J Jun et al.   ONCOGENE

A Functional Nuclear Epidermal Growth Factor Receptor, Src and Stat3 Heteromeric Complex in Pancreatic Cancer Cells

(2011) Soumya Jaganathan et al.   PLoS One

Crosstalk between the urokinase-type plasminogen activator receptor and EGF receptor variant III supports survival and growth of glioblastoma cells

(2011) J. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of EGFR induced autophagy sensitizes hormone refractory prostate cancer cells to adriamycin

(2011) Shuping Xu et al.   PROSTATE

PTEN Signaling pathways in glioblastoma

(2010) Dimpy Koul   CANCER BIOLOGY & THERAPY

Pro-survival AKT and ERK signaling from EGFR and mutant EGFRvIII enhances DNA double-strand break repair in human glioma cells

(2010) Sarah E. Golding et al.   CANCER BIOLOGY & THERAPY

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

EGFR and EGFRvIII interact with PUMA to inhibit mitochondrial translocalization of PUMA and PUMA-mediated apoptosis independent of EGFR kinase activity

(2010) Hu Zhu et al.   CANCER LETTERS

Epidermal Growth Factor Receptor Expression Identifies Functionally and Molecularly Distinct Tumor-Initiating Cells in Human Glioblastoma Multiforme and Is Required for Gliomagenesis

(2010) S. Mazzoleni et al.   CANCER RESEARCH

Coexpression Network Analysis Identifies Transcriptional Modules Related to Proastrocytic Differentiation and Sprouty Signaling in Glioma

(2010) A. E. Ivliev et al.   CANCER RESEARCH

Transcriptional Profiles of CD133+ and CD133- Glioblastoma-Derived Cancer Stem Cell Lines Suggest Different Cells of Origin

(2010) C. Lottaz et al.   CANCER RESEARCH

Cbl and Human Myeloid Neoplasms: The Cbl Oncogene Comes of Age: Figure 1.

(2010) Stephen C. Kales et al.   CANCER RESEARCH

Regulated Segregation of Kinase Dyrk1A during Asymmetric Neural Stem Cell Division Is Critical for EGFR-Mediated Biased Signaling

(2010) Sacri R. Ferron et al.   Cell Stem Cell

Oncogenic mutant forms of EGFR: Lessons in signal transduction and targets for cancer therapy

(2010) Gur Pines et al.   FEBS LETTERS

Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma

(2010) M.-d.-M. Inda et al.   GENES & DEVELOPMENT

Lipid raft localization of EGFR alters the response of cancer cells to the EGFR tyrosine kinase inhibitor gefitinib

(2010) Mary E. Irwin et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A Phase II study of anti–epidermal growth factor receptor radioimmunotherapy in the treatment of glioblastoma multiforme

(2010) Linna Li et al.   JOURNAL OF NEUROSURGERY

Cyclooxygenase-2 Is a Novel Transcriptional Target of the Nuclear EGFR-STAT3 and EGFRvIII-STAT3 Signaling Axes

(2010) H.-W. Lo et al.   MOLECULAR CANCER RESEARCH

Understanding resistance to EGFR inhibitors—impact on future treatment strategies

(2010) Deric L. Wheeler et al.   Nature Reviews Clinical Oncology

Safety and efficacy of erlotinib in first-relapse glioblastoma: a phase II open-label study

(2010) W. K. A. Yung et al.   NEURO-ONCOLOGY

NFKBIADeletion in Glioblastomas

(2010) Markus Bredel et al.   NEW ENGLAND JOURNAL OF MEDICINE

SPROUTY-2 and E-cadherin regulate reciprocally and dictate colon cancer cell tumourigenicity

(2010) A Barbáchano et al.   ONCOGENE

The Proneural Molecular Signature Is Enriched in Oligodendrogliomas and Predicts Improved Survival among Diffuse Gliomas

(2010) Lee A. D. Cooper et al.   PLoS One

Mig-6 controls EGFR trafficking and suppresses gliomagenesis

(2010) H. Ying et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer-derived mutations in the regulatory subunit p85  of phosphoinositide 3-kinase function through the catalytic subunit p110 

(2010) M. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stratified phase II trial of cetuximab in patients with recurrent high-grade glioma

(2009) B. Neyns et al.   ANNALS OF ONCOLOGY

Identification of small molecule inhibitors of pyruvate kinase M2

(2009) Matthew G. Vander Heiden et al.   BIOCHEMICAL PHARMACOLOGY

A phase I/II trial of GW572016 (lapatinib) in recurrent glioblastoma multiforme: clinical outcomes, pharmacokinetics and molecular correlation

(2009) Brian Thiessen et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Fyn and Src Are Effectors of Oncogenic Epidermal Growth Factor Receptor Signaling in Glioblastoma Patients

(2009) K. V. Lu et al.   CANCER RESEARCH

EGFRvIII and DNA Double-Strand Break Repair: A Molecular Mechanism for Radioresistance in Glioblastoma

(2009) B. Mukherjee et al.   CANCER RESEARCH

The Juxtamembrane Region of EGFR Takes Center Stage

(2009) Stevan R. Hubbard   CELL

The Green Tea Polyphenol EGCG Potentiates the Antiproliferative Activity of c-Met and Epidermal Growth Factor Receptor Inhibitors in Non-small Cell Lung Cancer Cells

(2009) S. A. Milligan et al.   CLINICAL CANCER RESEARCH

Akt-mediated regulation of NFκB and the essentialness of NFκB for the oncogenicity of PI3K and Akt

(2009) Dong Bai et al.   INTERNATIONAL JOURNAL OF CANCER

Epidermal Growth Factor Receptor Translocation to the Mitochondria

(2009) Michelle L. Demory et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Randomized Phase II Trial of Erlotinib Versus Temozolomide or Carmustine in Recurrent Glioblastoma: EORTC Brain Tumor Group Study 26034

(2009) Martin J. van den Bent et al.   JOURNAL OF CLINICAL ONCOLOGY

Upregulation of LRIG1 suppresses malignant glioma cell growth by attenuating EGFR activity

(2009) Fei Ye et al.   JOURNAL OF NEURO-ONCOLOGY

Therapeutic Inhibition of the Epidermal Growth Factor Receptor in High-Grade Gliomas: Where Do We Stand?

(2009) G. Karpel-Massler et al.   MOLECULAR CANCER RESEARCH

EGFRvIII and c-Met pathway inhibitors synergize against PTEN-null/EGFRvIII+ glioblastoma xenografts

(2009) B. Lal et al.   MOLECULAR CANCER THERAPEUTICS

PUMA, a potent killer with or without p53

(2009) J Yu et al.   ONCOGENE

Nuclear EGFR contributes to acquired resistance to cetuximab

(2009) C Li et al.   ONCOGENE

Glioblastoma Subclasses Can Be Defined by Activity among Signal Transduction Pathways and Associated Genomic Alterations

(2009) Cameron Brennan et al.   PLoS One

Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis

(2009) Haihao Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EGF and amphiregulin differentially regulate Cbl recruitment to endosomes and EGF receptor fate

(2008) Kathryn A. Stern et al.   BIOCHEMICAL JOURNAL

Gene expression analysis of glioblastomas identifies the major molecular basis for the prognostic benefit of younger age

(2008) Yohan Lee et al.   BMC Medical Genomics

Prognostic significance of c-Met expression in glioblastomas

(2008) Doo-Sik Kong et al.   CANCER

Survival of Cancer Cells Is Maintained by EGFR Independent of Its Kinase Activity

(2008) Zhang Weihua et al.   CANCER CELL

Inhibition of transcription factor STAT5b suppresses proliferation, induces G1 cell cycle arrest and reduces tumor cell invasion in human glioblastoma multiforme cells

(2008) Qin-Chuan Liang et al.   CANCER LETTERS

Constitutively Activated STAT3 Frequently Coexpresses with Epidermal Growth Factor Receptor in High-Grade Gliomas and Targeting STAT3 Sensitizes Them to Iressa and Alkylators

(2008) H.-W. Lo et al.   CLINICAL CANCER RESEARCH

Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway

(2008) N. de la Iglesia et al.   GENES & DEVELOPMENT

EGFR tyrosine kinase inhibition radiosensitizes and induces apoptosis in malignant glioma and childhood ependymoma xenografts

(2008) Birgit Geoerger et al.   INTERNATIONAL JOURNAL OF CANCER

Synergistic inhibition of head and neck tumor growth by green tea (−)‐epigallocatechin‐3‐gallate and EGFR tyrosine kinase inhibitor

(2008) Xin Zhang et al.   INTERNATIONAL JOURNAL OF CANCER

Signal Transducer and Activator of Transcription-3: A Molecular Hub for Signaling Pathways in Gliomas

(2008) E. C. Brantley et al.   MOLECULAR CANCER RESEARCH

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

Bead-based profiling of tyrosine kinase phosphorylation identifies SRC as a potential target for glioblastoma therapy

(2008) Jinyan Du et al.   NATURE BIOTECHNOLOGY

Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells

(2008) Khalid Al-Nedawi et al.   NATURE CELL BIOLOGY

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

(2008) Johan Skog et al.   NATURE CELL BIOLOGY

EGFRvIII expression and PTEN loss synergistically induce chromosomal instability and glial tumors

(2008) Li Li et al.   NEURO-ONCOLOGY

Nuclear epidermal growth factor receptor (EGFR) interacts with signal transducer and activator of transcription 5 (STAT5) in activating Aurora-A gene expression

(2008) Liang-Yi Hung et al.   NUCLEIC ACIDS RESEARCH

LRIG1 negatively regulates the oncogenic EGF receptor mutant EGFRvIII

(2008) M A Stutz et al.   ONCOGENE

Nutrient transporters in cancer: Relevance to Warburg hypothesis and beyond

(2008) Vadivel Ganapathy et al.   PHARMACOLOGY & THERAPEUTICS