Mechanisms of Mediator complex action in transcriptional activation

A structural perspective on Mediator function

(2012) Laurent Larivière et al.   CURRENT OPINION IN CELL BIOLOGY

Role of Mediator in Regulating Pol II Elongation and Nucleosome Displacement in Saccharomyces cerevisiae

(2012) S. B. Kremer et al.   GENETICS

Get Back TFIIF, Don't Let Me Gdown1

(2012) Joaquín M. Espinosa   MOLECULAR CELL

Mediator Complex Regulates Alternative mRNA Processing via the MED23 Subunit

(2012) Yan Huang et al.   MOLECULAR CELL

Transcriptional Regulation by Pol II(G) Involving Mediator and Competitive Interactions of Gdown1 and TFIIF with Pol II

(2012) Miki Jishage et al.   MOLECULAR CELL

Functional Association of Gdown1 with RNA Polymerase II Poised on Human Genes

(2012) Bo Cheng et al.   MOLECULAR CELL

Structure of the Mediator head module

(2012) Laurent Larivière et al.   NATURE

The Arabidopsis Mediator Subunit MED25 Differentially Regulates Jasmonate and Abscisic Acid Signaling through Interacting with the MYC2 and ABI5 Transcription Factors

(2012) R. Chen et al.   PLANT CELL

MEDIATOR25 Acts as an Integrative Hub for the Regulation of Jasmonate-Responsive Gene Expression in Arabidopsis

(2012) V. Cevik et al.   PLANT PHYSIOLOGY

Med5(Nut1) and Med17(Srb4) Are Direct Targets of Mediator Histone H4 Tail Interactions

(2012) Zhongle Liu et al.   PLoS One

Analysis of Gal4-directed transcription activation using Tra1 mutants selectively defective for interaction with Gal4

(2012) L. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mediator Acts Upstream of the Transcriptional Activator Gal4

(2012) Keven Ang et al.   PLOS BIOLOGY

Human Mediator Subunit MED26 Functions as a Docking Site for Transcription Elongation Factors

(2011) Hidehisa Takahashi et al.   CELL

Function and regulation of the Mediator complex

(2011) Ronald C Conaway et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Control of final organ size by Mediator complex subunit 25 in Arabidopsis thaliana

(2011) R. Xu et al.   DEVELOPMENT

The role of Mediator in small and long noncoding RNA production inArabidopsis thaliana

(2011) Yun Ju Kim et al.   EMBO JOURNAL

Distinct role of Mediator tail module in regulation of SAGA-dependent, TATA-containing genes in yeast

(2011) Suraiya A Ansari et al.   EMBO JOURNAL

Tra1 has specific regulatory roles, rather than global functions, within the SAGA co-activator complex

(2011) Dominique Helmlinger et al.   EMBO JOURNAL

Mediator coordinates PIC assembly with recruitment of CHD1

(2011) J. J. Lin et al.   GENES & DEVELOPMENT

Novel Role for Mediator Complex Subunit Srb5/Med18 in Termination of Transcription

(2011) Banupriya Mukundan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Acidic Transcription Activator Gcn4 Binds the Mediator Subunit Gal11/Med15 Using a Simple Protein Interface Forming a Fuzzy Complex

(2011) Peter S. Brzovic et al.   MOLECULAR CELL

Architecture of the Mediator head module

(2011) Tsuyoshi Imasaki et al.   NATURE

Structure and VP16 binding of the Mediator Med25 activator interaction domain

(2011) Erika Vojnic et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the VP16 transactivator target in the Mediator

(2011) Alexander G Milbradt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mediator head subcomplex Med11/22 contains a common helix bundle building block with a specific function in transcription initiation complex stabilization

(2011) Martin Seizl et al.   NUCLEIC ACIDS RESEARCH

Histone modifications influence mediator interactions with chromatin

(2011) Xuefeng Zhu et al.   NUCLEIC ACIDS RESEARCH

The Arabidopsis thaliana Med25 mediator subunit integrates environmental cues to control plant development

(2011) N. Elfving et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MED23 Mutation Links Intellectual Disability to Dysregulation of Immediate Early Gene Expression

(2011) S. Hashimoto et al.   SCIENCE

Direct Interaction of RNA Polymerase II and Mediator Required for Transcription in Vivo

(2011) J. Soutourina et al.   SCIENCE

MED12, the Mediator Complex Subunit 12 Gene, Is Mutated at High Frequency in Uterine Leiomyomas

(2011) N. Makinen et al.   SCIENCE

Diverse roles of the Mediator complex in plants

(2011) Brendan N. Kidd et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Control of gene transcription by Mediator in chromatin

(2011) David Ries et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Interactions between subunits of the Mediator complex with gene-specific transcription factors

(2011) Tilman Borggrefe et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Mediator-dependent nuclear receptor function

(2011) Wei Chen et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Molecular Architecture of the Human Mediator–RNA Polymerase II–TFIIF Assembly

(2011) Carrie Bernecky et al.   PLOS BIOLOGY

ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes

(2010) Arnaud R Krebs et al.   EMBO REPORTS

A Chromatin-remodeling Protein Is a Component of Fission Yeast Mediator

(2010) Olga Khorosjutina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MED14 Tethers Mediator to the N-Terminal Domain of Peroxisome Proliferator-Activated Receptor   and Is Required for Full Transcriptional Activity and Adipogenesis

(2010) L. Grontved et al.   MOLECULAR AND CELLULAR BIOLOGY

Med25 Is Required for RNA Polymerase II Recruitment to Specific Promoters, Thus Regulating Xenobiotic and Lipid Metabolism in Human Liver

(2010) R. Rana et al.   MOLECULAR AND CELLULAR BIOLOGY

Cyclin-Dependent Kinase 8 Positively Cooperates with Mediator To Promote Thyroid Hormone Receptor-Dependent Transcriptional Activation

(2010) M. Belakavadi et al.   MOLECULAR AND CELLULAR BIOLOGY

Mechanism of Mediator Recruitment by Tandem Gcn4 Activation Domains and Three Gal11 Activator-Binding Domains

(2010) E. Herbig et al.   MOLECULAR AND CELLULAR BIOLOGY

Mediator and cohesin connect gene expression and chromatin architecture

(2010) Michael H. Kagey et al.   NATURE

The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation

(2010) Sohail Malik et al.   NATURE REVIEWS GENETICS

p53 activates transcription by directing structural shifts in Mediator

(2010) Krista D Meyer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

CDK8 is a positive regulator of transcriptional elongation within the serum response network

(2010) Aaron J Donner et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mediator Head module structure and functional interactions

(2010) Gang Cai et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Activator-Mediator binding regulates Mediator-cofactor interactions

(2010) C. C. Ebmeier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The human Mediator complex: a versatile, genome-wide regulator of transcription

(2010) Dylan J. Taatjes   TRENDS IN BIOCHEMICAL SCIENCES

The Med8 mediator subunit interacts with the Rpb4 subunit of RNA polymerase II and Ace2 transcriptional activator inSchizosaccharomyces pombe

(2009) Surbhi Mehta et al.   FEBS LETTERS

The human CDK8 subcomplex is a molecular switch that controls Mediator coactivator function

(2009) M. T. Knuesel et al.   GENES & DEVELOPMENT

Activator Gcn4 Employs Multiple Segments of Med15/Gal11, Including the KIX Domain, to Recruit Mediator to Target Genesin Vivo

(2009) Iness Jedidi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of the Varicella-Zoster Virus IE62 N-Terminal Acidic Transactivating Domain and Its Interaction with the Human Mediator Complex

(2009) S. Yamamoto et al.   JOURNAL OF VIROLOGY

Snf1-independent, glucose-resistant transcription of Adr1-dependent genes in a mediator mutant ofSaccharomyces cerevisiae

(2009) Elton T. Young et al.   MOLECULAR MICROBIOLOGY

The Mediator Complex Subunit PFT1 Is a Key Regulator of Jasmonate-Dependent Defense in Arabidopsis

(2009) B. N. Kidd et al.   PLANT CELL

Mediator complex association with constitutively transcribed genes in yeast

(2009) S. A. Ansari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mediator Structural Conservation and Implications for the Regulation Mechanism

(2009) Gang Cai et al.   STRUCTURE

Identification, structure, and functional requirement of the Mediator submodule Med7N/31

(2008) Tobias Koschubs et al.   EMBO JOURNAL

Mediator Subunit Gal11p/MED15 Is Required for Fatty Acid-dependent Gene Activation by Yeast Transcription Factor Oaf1p

(2008) Jitendra K. Thakur et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Varicella-Zoster Virus IE62 Protein Utilizes the Human Mediator Complex in Promoter Activation

(2008) M. Yang et al.   JOURNAL OF VIROLOGY

MyoD Targets TAF3/TRF3 to Activate Myogenin Transcription

(2008) Maria Divina E. Deato et al.   MOLECULAR CELL

Mediator-Dependent Recruitment of TFIIH Modules in Preinitiation Complex

(2008) Cyril Esnault et al.   MOLECULAR CELL

A nuclear receptor-like pathway regulating multidrug resistance in fungi

(2008) Jitendra K. Thakur et al.   NATURE

Activated transcription via mammalian amino acid response elements does not require enhanced recruitment of the Mediator complex

(2008) Michelle M. Thiaville et al.   NUCLEIC ACIDS RESEARCH

Comparative genomics supports a deep evolutionary origin for the large, four-module transcriptional mediator complex

(2008) Henri-Marc Bourbon   NUCLEIC ACIDS RESEARCH