Article
Multidisciplinary Sciences
Michael Spencer Chapman, Anna Maria Ranzoni, Brynelle Myers, Nicholas Williams, Tim H. H. Coorens, Emily Mitchell, Timothy Butler, Kevin J. Dawson, Yvette Hooks, Luiza Moore, Jyoti Nangalia, Philip S. Robinson, Kenichi Yoshida, Elizabeth Hook, Peter J. Campbell, Ana Cvejic
Summary: By reconstructing a phylogenetic tree of blood development in healthy human fetuses, it was found that individual haematopoietic progenitors acquire multiple somatic mutations by 18 weeks after conception. The data also support a hypoblast origin of the extra-embryonic mesoderm and primitive blood in humans.
Article
Developmental Biology
Shizheng Zhao, Ao Zhang, Hao Zhu, Zilong Wen
Summary: The study reports the identification and characterization of a new member of the ETS transcription factors, Spi2, in ray-finned fish. It shows that Spi2 is crucial for hematopoietic stem and progenitor cell development and myeloid lineage differentiation. A reporter line is created to track these cells from early development to adulthood.
Article
Cell & Tissue Engineering
Lina Wang, Yongjun Piao, Dongyue Zhang, Wenli Feng, Chenchen Wang, Xiaoxi Cui, Qian Ren, Xiaofan Zhu, Guoguang Zheng
Summary: This study demonstrates the negative role of Fbxw11 in the maintenance and repopulation capacity of HSPCs, and provides valuable transcriptomic references for HSPC homeostasis.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Hematology
Laura R. Goldberg
Summary: Extracellular vesicles (EVs) play a critical role in modulating hematopoiesis within the bone marrow microenvironment and may be key mediators of HSC aging. Studies have shown their involvement in numerous age-related biologic processes and diseases, influencing both normal and malignant hematopoiesis.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Cell & Tissue Engineering
Kenji Kitajima, Minako Shingai, Hikaru Ando, Mako Hamasaki, Takahiko Hara
Summary: Researchers developed a novel method for hematopoietic differentiation of human-induced pluripotent stem cells to address the issue of low production of CD38(+) hematopoietic progenitor cells. They found that the lack of FLT3 expression was responsible for this problem and solved it by adding interferon-gamma.
Review
Biochemistry & Molecular Biology
Takeshi Fujino, Shuhei Asada, Susumu Goyama, Toshio Kitamura
Summary: This review discusses the causes of hematopoietic stem cell aging, including both intrinsic and extrinsic factors. Epigenetics and inflammation have been found to be involved in the connection between HSC aging, clonality, and oncogenesis. Clarifying the mechanisms of HSC aging has accelerated the development of therapeutic interventions for rejuvenating HSCs.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Masayuki Yamashita, Atsushi Iwama
Summary: This review summarizes the changes in hematopoietic stem cells (HSCs) during aging and how different clones of HSCs can be expanded. Research shows that in mice and humans, the clonal behavior of HSCs is closely related to the risk of hematological malignancies and cardiovascular diseases. Therefore, understanding the impact of aging on the hematopoietic system is critical to prevent or overcome age-related changes in the blood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Claudia Morganti, Keisuke Ito
Summary: Mitochondrial dysfunction and stem cell exhaustion are characteristic features of aging, particularly in the hematopoietic system. Understanding the key mechanisms of HSC aging, including mitochondrial ROS production and alterations in metabolism, could lead to the identification of new therapeutic targets to prevent, delay, or reverse aspects of the aging process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Na Yuan, Wen Wei, Li Ji, Jiawei Qian, Zhicong Jin, Hong Liu, Li Xu, Lei Li, Chen Zhao, Xueqin Gao, Yulong He, Mingyuan Wang, Longhai Tang, Yixuan Fang, Jianrong Wang
Summary: The bone marrow niche, responsible for maintaining hematopoietic stem cell homeostasis, declines in function with aging and hematological malignancies. This study reveals that disrupting autophagy in HSCs accelerates niche aging, while transplantation of young donor HSCs repairs the niche environment. Further investigation shows that HSCs transdifferentiate into functional niche cells, including mesenchymal stromal cells and endothelial cells, in an autophagy-dependent manner. These findings provide a clinical solution to rejuvenate an aged or damaged bone marrow hematopoietic niche.
Article
Developmental Biology
Atesh K. Worthington, Taylor Cool, Donna M. Poscablo, Adeel Hussaini, Anna E. Beaudin, E. Camilla Forsberg
Summary: This study further investigated the development of tissue-resident lymphoid cells (TLCs) in mice and explored the roles of two cytokine receptors, Flk2 and IL7R alpha, in traditional lymphopoiesis. The findings revealed the essential role of IL7R alpha in the generation of TLCs.
Article
Cell Biology
Yun-Qiao Li, Yandong Gong, Siyuan Hou, Tao Huang, Haizhen Wang, Di Liu, Yanli Ni, Chaojie Wang, Junliang Wang, Jun Hou, Ruichuang Yang, Jing Yan, Guangyu Zhang, Bing Liu, Yu Lan
Summary: This study reveals the spatiotemporal and functional heterogeneity of Hematopoietic stem cells (HSCs) derived from Hemogenic Endothelial Cells (HECs) during embryonic development. PK44 cells in the AGM region and yolk sac display similar developmental dynamics and functional characteristics with endothelial and hematopoietic features. They demonstrate multilineage reconstitution capacity and transcriptional differences, providing a fundamental basis for future research on HSC generation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Ram Lakhan, Chozha V. Rathinam
Summary: Deletion of canonical notch pathways in hematopoietic stem cells leads to compromised HSC maintenance and functions in response to stressors, while upregulating key notch target genes and increasing notch activity, which establish a functional link between Hif and Notch pathways in hematopoiesis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell & Tissue Engineering
Zheng-Li Xu, Xiao-Jun Huang
Summary: Allogeneic hematopoietic stem cell transplantation is widely used in treating hematological diseases, with optimized grafts being crucial for improving outcomes. However, there is currently no uniform standard for optimized grafts in transplantation. Future research may focus on identifying the cellular elements responsible for the effects of allo-HSCT.
STEM CELLS TRANSLATIONAL MEDICINE
(2021)
Review
Cell Biology
Anna Konturek-Ciesla, David Bryder
Summary: Appropriate production of mature blood cells is essential for organismal health. This article describes tools and methods for tracing HSC lineage in mice and integrating them with single-cell molecular analysis. By combining new insights from experiments with past knowledge, we gain a better understanding of HSC-derived hematopoiesis in humans.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Bo Yu, Bingyan Wu, Pingshan Hong, Huan Peng, Mengyun Zhang, Qi Zhang, Lijuan Liu, Xiaofei Liu, Yang Geng, Jinyong Wang, Yu Lan
Summary: This study reveals that the coordinated action of Runx1, Hoxa9, Hlf, and Hoxa7 leads to the generation of hematopoietic progenitor cells with the capacity for multilineage hematopoietic reconstitution.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)