Impact of T cell selection methods in the success of clinical adoptive immunotherapy

Dynamics of Proximal Signaling Events after TCR/CD8-Mediated Induction of Proliferation or Apoptosis in Mature CD8+ T Cells

(2014) X. Wang et al.   JOURNAL OF IMMUNOLOGY

Novel interferon-based pre-transplantation conditioning in the treatment of a congenital metabolic disorder

(2013) T. Sato et al.   BLOOD

Viral-specific adoptive immunotherapy after allo-SCT: the role of multimer-based selection strategies

(2013) N Ramírez et al.   BONE MARROW TRANSPLANTATION

Simultaneous activation of T helper function can augment the potency of dendritic cell-based cancer immunotherapy

(2013) Koji Teramoto et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Cellular immunotherapy for refractory hematological malignancies

(2013) John L Reagan et al.   Journal of Translational Medicine

A CD19/Fc fusion protein for detection of anti-CD19 chimeric antigen receptors

(2013) Satiro N De Oliveira et al.   Journal of Translational Medicine

Chimeric Antigen Receptor–Modified T Cells for Acute Lymphoid Leukemia

(2013) Stephan A. Grupp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Improving the efficacy and safety of engineered T cell therapy for cancer

(2012) Huan Shi et al.   CANCER LETTERS

Redirecting Gene-Modified T Cells toward Various Cancer Types Using Tagged Antibodies

(2012) K. Tamada et al.   CLINICAL CANCER RESEARCH

Depletion of Tregs in vivo: a promising approach to enhance antitumor immunity without autoimmunity

(2012) Rena Morita et al.   Immunotherapy

A Combination of Local Inflammation and Central Memory T Cells Potentiates Immunotherapy in the Skin

(2012) S. Fiorenza et al.   JOURNAL OF IMMUNOLOGY

Phenotypic and Functional Attributes of Lentivirus-modified CD19-specific Human CD8+ Central Memory T Cells Manufactured at Clinical Scale

(2012) Xiuli Wang et al.   JOURNAL OF IMMUNOTHERAPY

A phase I clinical trial of adoptive transfer of folate receptor-alpha redirected autologous T cells for recurrent ovarian cancer

(2012) Lana E Kandalaft et al.   Journal of Translational Medicine

Generation of CD19-chimeric antigen receptor modified CD8+ T cells derived from virus-specific central memory T cells

(2011) S. Terakura et al.   BLOOD

Adoptive immunotherapy with unselected or EBV-specific T cells for biopsy-proven EBV+ lymphomas after allogeneic hematopoietic cell transplantation

(2011) E. Doubrovina et al.   BLOOD

Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma

(2011) C. U. Louis et al.   BLOOD

In Vivo Persistence, Tumor Localization, and Antitumor Activity of CAR-Engineered T Cells Is Enhanced by Costimulatory Signaling through CD137 (4-1BB)

(2011) D.-G. Song et al.   CANCER RESEARCH

Alloreactive and leukemia-reactive T cells are preferentially derived from naive precursors in healthy donors: implications for immunotherapy with memory T cells

(2011) E. Distler et al.   HAEMATOLOGICA

CARs on Track in the Clinic

(2011) Donald B Kohn et al.   MOLECULAR THERAPY

Memory in disguise

(2011) Federica Sallusto et al.   NATURE MEDICINE

A human memory T cell subset with stem cell–like properties

(2011) Luca Gattinoni et al.   NATURE MEDICINE

Inducible Apoptosis as a Safety Switch for Adoptive Cell Therapy

(2011) Antonio Di Stasi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Chimeric Antigen Receptor–Modified T Cells in Chronic Lymphoid Leukemia

(2011) David L. Porter et al.   NEW ENGLAND JOURNAL OF MEDICINE

T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced Leukemia

(2011) M. Kalos et al.   Science Translational Medicine

Derivation of human T lymphocytes from cord blood and peripheral blood with antiviral and antileukemic specificity from a single culture as protection against infection and relapse after stem cell transplantation

(2010) K. P. Micklethwaite et al.   BLOOD

High doses of mother's lymphocyte infusion to treat EBV-positive T-cell lymphoproliferative disorders in childhood

(2010) Q. Wang et al.   BLOOD

Human effector CD8+ T cells derived from naive rather than memory subsets possess superior traits for adoptive immunotherapy

(2010) C. S. Hinrichs et al.   BLOOD

Allogeneic virus-specific T cells with HLA alloreactivity do not produce GVHD in human subjects

(2010) J. J. Melenhorst et al.   BLOOD

Expansion of EBNA1-specific effector T cells in posttransplantation lymphoproliferative disorders

(2010) K. Jones et al.   BLOOD

Effective and long-term control of EBV PTLD after transfer of peptide-selected T cells

(2010) A. Moosmann et al.   BLOOD

Adoptive transfer of pp65-specific T cells for the treatment of chemorefractory cytomegalovirus disease or reactivation after haploidentical and matched unrelated stem cell transplantation

(2010) T. Feuchtinger et al.   BLOOD

Redirecting T-cell specificity by introducing a tumor-specific chimeric antigen receptor

(2010) B. Jena et al.   BLOOD

Directly Selected Cytomegalovirus-Reactive Donor T Cells Confer Rapid and Safe Systemic Reconstitution of Virus-Specific Immunity Following Stem Cell Transplantation

(2010) K. S. Peggs et al.   CLINICAL INFECTIOUS DISEASES

Adoptive T cell therapy of cancer

(2010) Malcolm K Brenner et al.   CURRENT OPINION IN IMMUNOLOGY

Streptamer-based selection of WT1-specific CD8+ T cells for specific donor lymphocyte infusions

(2010) Xinchao Wang et al.   EXPERIMENTAL HEMATOLOGY

Tumor-reactive CD4+T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts

(2010) Sergio A. Quezada et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Engineering virus-specific T cells that target HBV infected hepatocytes and hepatocellular carcinoma cell lines

(2010) Adam J. Gehring et al.   JOURNAL OF HEPATOLOGY

Selected Murine Residues Endow Human TCR with Enhanced Tumor Recognition

(2010) G. Bialer et al.   JOURNAL OF IMMUNOLOGY

IL-7 Is Essential for Homeostatic Control of T Cell Metabolism In Vivo

(2010) S. R. Jacobs et al.   JOURNAL OF IMMUNOLOGY

Safer CARS

(2010) Helen E Heslop   MOLECULAR THERAPY

Treatment of Chronic Lymphocytic Leukemia With Genetically Targeted Autologous T Cells: Case Report of an Unforeseen Adverse Event in a Phase I Clinical Trial

(2010) Renier Brentjens et al.   MOLECULAR THERAPY

Case Report of a Serious Adverse Event Following the Administration of T Cells Transduced With a Chimeric Antigen Receptor Recognizing ERBB2

(2010) Richard A Morgan et al.   MOLECULAR THERAPY

Monitoring of NY-ESO-1 specific CD4+ T cells using molecularly defined MHC class II/His-tag-peptide tetramers

(2010) M. Ayyoub et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adoptive transfer and selective reconstitution of streptamer-selected cytomegalovirus-specific CD8+ T cells leads to virus clearance in patients after allogeneic peripheral blood stem cell transplantation

(2010) Anita Schmitt et al.   TRANSFUSION

Adoptive T-Cell Therapy of a Lung Transplanted Patient with Severe CMV Disease and Resistance to Antiviral Therapy

(2009) G. Brestrich et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Successful Immunotherapy of HCMV Disease Using Virus-Specific T Cells Expanded from an Allogeneic Stem Cell Transplant Recipient

(2009) G. R. Hill et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen

(2009) L. A. Johnson et al.   BLOOD

Cytotoxic T lymphocyte therapy with donor T cells prevents and treats adenovirus and Epstein-Barr virus infections after haploidentical and matched unrelated stem cell transplantation

(2009) A. M. Leen et al.   BLOOD

Functionally active virus-specific T cells that target CMV, adenovirus, and EBV can be expanded from naive T-cell populations in cord blood and will target a range of viral epitopes

(2009) P. J. Hanley et al.   BLOOD

The transfer of adaptive immunity to CMV during hematopoietic stem cell transplantation is dependent on the specificity and phenotype of CMV-specific T cells in the donor

(2009) P. Scheinberg et al.   BLOOD

Long-term outcome of EBV-specific T-cell infusions to prevent or treat EBV-related lymphoproliferative disease in transplant recipients

(2009) H. E. Heslop et al.   BLOOD

Viral disease prevention after hematopoietic cell transplantation

(2009) J Zaia et al.   BONE MARROW TRANSPLANTATION

Background to hematopoietic cell transplantation, including post transplant immune recovery

(2009) C Mackall et al.   BONE MARROW TRANSPLANTATION

Multimer technologies for detection and adoptive transfer of antigen-specific T cells

(2009) Rosaely Casalegno-Garduño et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

A novel haplo-identical adoptive CTL therapy as a treatment for EBV-associated lymphoma after stem cell transplantation

(2009) Michael Uhlin et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Cytomegalovirus‐Specific T Cell Immunotherapy Promotes Restoration of Durable Functional Antiviral Immunity following Allogeneic Stem Cell Transplantation

(2009) Karl S. Peggs et al.   CLINICAL INFECTIOUS DISEASES

Infusion of suicide-gene-engineered donor lymphocytes after family haploidentical haemopoietic stem-cell transplantation for leukaemia (the TK007 trial): a non-randomised phase I–II study

(2009) Fabio Ciceri et al.   LANCET ONCOLOGY

Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells

(2009) Luca Gattinoni et al.   NATURE MEDICINE

Adoptively transferred effector cells derived from naive rather than central memory CD8+ T cells mediate superior antitumor immunity

(2009) C. S. Hinrichs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhancing the in vivo expansion of adoptively transferred EBV-specific CTL with lymphodepleting CD45 monoclonal antibodies in NPC patients

(2008) C. U. Louis et al.   BLOOD

Prophylactic infusion of cytomegalovirus-specific cytotoxic T lymphocytes stimulated with Ad5f35pp65 gene-modified dendritic cells after allogeneic hemopoietic stem cell transplantation

(2008) K. P. Micklethwaite et al.   BLOOD

Acute myeloid leukemia (AML)-reactive cytotoxic T lymphocyte clones rapidly expanded from CD8+ CD62L(high)+ T cells of healthy donors prevent AML engraftment in NOD/SCID IL2Rγnull mice

(2008) Eva Distler et al.   EXPERIMENTAL HEMATOLOGY

Human regulatory T cells: role in autoimmune disease and therapeutic opportunities

(2008) Todd M. Brusko et al.   IMMUNOLOGICAL REVIEWS

Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates

(2008) Carolina Berger et al.   JOURNAL OF CLINICAL INVESTIGATION

Adoptive Cell Therapy for Patients With Metastatic Melanoma: Evaluation of Intensive Myeloablative Chemoradiation Preparative Regimens

(2008) Mark E. Dudley et al.   JOURNAL OF CLINICAL ONCOLOGY

Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma

(2008) Martin A Pule et al.   NATURE MEDICINE