Regulation of organogenesis and stem cell properties by T-box transcription factors

The T-box transcription factor Brachyury regulates epithelial–mesenchymal transition in association with cancer stem-like cells in adenoid cystic carcinoma cells

(2012) Miyuki Shimoda et al.   BMC CANCER

T-box transcription factor TBX3 reprogrammes mature cardiac myocytes into pacemaker-like cells

(2012) Martijn L. Bakker et al.   CARDIOVASCULAR RESEARCH

β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis

(2012) Joseph Rosenbluh et al.   CELL

Brachyury, a Driver of the Epithelial-Mesenchymal Transition, Is Overexpressed in Human Lung Tumors: An Opportunity for Novel Interventions against Lung Cancer

(2012) M. Roselli et al.   CLINICAL CANCER RESEARCH

Endothelin-induced differentiation of Nkx2.5+ cardiac progenitor cells into pacemaking cells

(2012) Xi Zhang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The ulnar-mammary syndrome gene, Tbx3, is a direct target of the retinoic acid signaling pathway, which regulates its expression during mouse limb development

(2012) Reyna Deeya Ballim et al.   MOLECULAR BIOLOGY OF THE CELL

An RNA interference screen uncovers a new molecule in stem cell self-renewal and long-term regeneration

(2012) Ting Chen et al.   NATURE

Heart repair by reprogramming non-myocytes with cardiac transcription factors

(2012) Kunhua Song et al.   NATURE

In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes

(2012) Li Qian et al.   NATURE

A Homolog of Subtilisin-Like Proprotein Convertase 7 Is Essential to Anterior Neural Development in Xenopus

(2012) Sema Senturker et al.   PLoS One

Fibroblast growth factor 10 gene regulation in the second heart field by Tbx1, Nkx2-5, and Islet1 reveals a genetic switch for down-regulation in the myocardium

(2012) Y. Watanabe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diverse functional networks of Tbx3 in development and disease

(2012) Andrew J. Washkowitz et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Transcriptional Control in Cardiac Progenitors: Tbx1 Interacts with the BAF Chromatin Remodeling Complex and Regulates Wnt5a

(2012) Li Chen et al.   PLoS Genetics

Tbx1, subpulmonary myocardium and conotruncal congenital heart defects

(2011) Pauline Parisot et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

TBX3 over-expression causes mammary gland hyperplasia and increases mammary stem-like cells in an inducible transgenic mouse model

(2011) Jing Liu et al.   BMC DEVELOPMENTAL BIOLOGY

Mechanisms of T-box gene function in the developing heart

(2011) F. Greulich et al.   CARDIOVASCULAR RESEARCH

TBX22 Mutation Associated with Cleft Lip/Palate, Hypodontia, and Limb Anomaly

(2011) Arunee Kaewkhampa et al.   CLEFT PALATE-CRANIOFACIAL JOURNAL

Myocardial Tbx20 regulates early atrioventricular canal formation and endocardial epithelial–mesenchymal transition via Bmp2

(2011) Xiaoqiang Cai et al.   DEVELOPMENTAL BIOLOGY

Tbx20 regulation of cardiac cell proliferation and lineage specialization during embryonic and fetal development in vivo

(2011) Santanu Chakraborty et al.   DEVELOPMENTAL BIOLOGY

Regulation of limb bud initiation and limb-type morphology

(2011) Veronique Duboc et al.   DEVELOPMENTAL DYNAMICS

Neuronal regeneration in a zebrafish model of adult brain injury

(2011) N. Kishimoto et al.   Disease Models & Mechanisms

Melanoblasts in culture as an in vitro system to determine molecular changes in melanoma

(2011) Anja Katrin Bosserhoff et al.   EXPERIMENTAL DERMATOLOGY

Dynamic expression of Tbx2 and Tbx3 in developing mouse pancreas

(2011) Salma Begum et al.   GENE EXPRESSION PATTERNS

Pluripotency factors regulate definitive endoderm specification through eomesodermin

(2011) A. K. K. Teo et al.   GENES & DEVELOPMENT

Glycogen Synthase Kinase-3 Facilitates Con A-Induced IFN- -Mediated Immune Hepatic Injury

(2011) C.-C. Tsai et al.   JOURNAL OF IMMUNOLOGY

The T-box transcription factor Eomesodermin acts upstream of Mesp1 to specify cardiac mesoderm during mouse gastrulation

(2011) Ita Costello et al.   NATURE CELL BIOLOGY

Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection

(2011) Charlly Kao et al.   NATURE IMMUNOLOGY

Sequential generation of olfactory bulb glutamatergic neurons by Neurog2-expressing precursor cells

(2011) Eleanor Winpenny et al.   Neural Development

Comparative Analysis of 3D Expression Patterns of Transcription Factor Genes and Digit Fate Maps in the Developing Chick Wing

(2011) Malcolm Fisher et al.   PLoS One

Related pituitary cell lineages develop into interdigitated 3D cell networks

(2011) L. Budry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the DNA-bound T-box domain of human TBX1, a transcription factor associated with the DiGeorge syndrome

(2011) Kamel El Omari et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Tbx20, Smads, and the Atrioventricular Canal

(2011) Reena Singh et al.   TRENDS IN CARDIOVASCULAR MEDICINE

PMA-induced up-regulation of TBX3 is mediated by AP-1 and contributes to breast cancer cell migration

(2010) Shaheen Mowla et al.   BIOCHEMICAL JOURNAL

Direct Reprogramming of Fibroblasts into Functional Cardiomyocytes by Defined Factors

(2010) Masaki Ieda et al.   CELL

A divergent Tbx6-related gene and Tbx6 are both required for neural crest and intermediate mesoderm development in Xenopus

(2010) Elizabeth M. Callery et al.   DEVELOPMENTAL BIOLOGY

Paraxial T-box genes, Tbx6 and Tbx1, are required for cranial chondrogenesis and myogenesis

(2010) Shunsuke Tazumi et al.   DEVELOPMENTAL BIOLOGY

Regulation of Tbx22 during facial and palatal development

(2010) Alisa Fuchs et al.   DEVELOPMENTAL DYNAMICS

Interferons Direct Th2 Cell Reprogramming to Generate a Stable GATA-3+T-bet+ Cell Subset with Combined Th2 and Th1 Cell Functions

(2010) Ahmed N. Hegazy et al.   IMMUNITY

Dual Functions of T-Box 3 (Tbx3) in the Control of Self-renewal and Extraembryonic Endoderm Differentiation in Mouse Embryonic Stem Cells

(2010) Rui Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pregenerative medicine: developmental paradigms in the biology of cardiovascular regeneration

(2010) B. Alexander Yi et al.   JOURNAL OF CLINICAL INVESTIGATION

The polycomb group gene product Ezh2 regulates proliferation and differentiation of murine hepatic stem/progenitor cells

(2010) Ryutaro Aoki et al.   JOURNAL OF HEPATOLOGY

Structural Basis of TBX5–DNA Recognition: The T-Box Domain in Its DNA-Bound and -Unbound Form

(2010) Christian U. Stirnimann et al.   JOURNAL OF MOLECULAR BIOLOGY

Guided Cardiopoiesis Enhances Therapeutic Benefit of Bone Marrow Human Mesenchymal Stem Cells in Chronic Myocardial Infarction

(2010) Atta Behfar et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The T-box brain 1 (Tbr1) transcription factor inhibits astrocyte formation in the olfactory bulb and regulates neural stem cell fate

(2010) Héctor R. Méndez-Gómez et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

A Pituitary-Specific Enhancer of the POMC Gene with Preferential Activity in Corticotrope Cells

(2010) David Langlais et al.   MOLECULAR ENDOCRINOLOGY

Tbx3 improves the germ-line competency of induced pluripotent stem cells

(2010) Jianyong Han et al.   NATURE

Epigenetic inactivation of T-box transcription factor 5, a novel tumor suppressor gene, is associated with colon cancer

(2010) J Yu et al.   ONCOGENE

Expression of PSCA, PIWIL1, and TBX2 in Endometrial Adenocarcinoma

(2010) Wen-Kang Liu et al.   ONKOLOGIE

HOXB13, a Target of DNMT3B, Is Methylated at an Upstream CpG Island, and Functions as a Tumor Suppressor in Primary Colorectal Tumors

(2010) Kalpana Ghoshal et al.   PLoS One

Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signaling

(2010) C. M. Fillmore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tbx3: another important piece fitted into the pluripotent stem cell puzzle

(2010) Melinda K Pirity et al.   Stem Cell Research & Therapy

Ulnar mammary syndrome andTBX3: Expanding the phenotype

(2009) Helen Linden et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Protein interactions at the heart of cardiac chamber formation

(2009) Cornelis J.J. Boogerd et al.   ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

Increased T-bet+ cytotoxic effectors and type I interferon-mediated processes in chronic graft-versus-host disease of the oral mucosa

(2009) M. M. Imanguli et al.   BLOOD

Expression and requirement of T-box transcription factors Tbx2 and Tbx3 during secondary palate development in the mouse

(2009) Susann Zirzow et al.   DEVELOPMENTAL BIOLOGY

Involvement of Ngn2, Tbr and NeuroD proteins during postnatal olfactory bulb neurogenesis

(2009) Laurent Roybon et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

A parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cells

(2009) Hitoshi Niwa et al.   NATURE

Directed transdifferentiation of mouse mesoderm to heart tissue by defined factors

(2009) Jun K. Takeuchi et al.   NATURE

Adult generation of glutamatergic olfactory bulb interneurons

(2009) Monika S Brill et al.   NATURE NEUROSCIENCE

TBX15 Mutations Cause Craniofacial Dysmorphism, Hypoplasia of Scapula and Pelvis, and Short Stature in Cousin Syndrome

(2008) Ekkehart Lausch et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Tbx3 Represses E-Cadherin Expression and Enhances Melanoma Invasiveness

(2008) M. Rodriguez et al.   CANCER RESEARCH

TBX3 Is Overexpressed in Breast Cancer and Represses p14ARF by Interacting with Histone Deacetylases

(2008) W. Yarosh et al.   CANCER RESEARCH

Generation of Functional Murine Cardiac Myocytes From Induced Pluripotent Stem Cells

(2008) Christina Mauritz et al.   CIRCULATION

Tbx3 Is Required for Outflow Tract Development

(2008) Karim Mesbah et al.   CIRCULATION RESEARCH

Transcription Factor Tbx3 Is Required for the Specification of the Atrioventricular Conduction System

(2008) Martijn L. Bakker et al.   CIRCULATION RESEARCH

Formation of the Sinus Node Head and Differentiation of Sinus Node Myocardium Are Independently Regulated by Tbx18 and Tbx3

(2008) Cornelia Wiese et al.   CIRCULATION RESEARCH

Tbx3 controls the fate of hepatic progenitor cells in liver development by suppressing p19ARF expression

(2008) A. Suzuki et al.   DEVELOPMENT

Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac development

(2008) Meenakshi Maitra et al.   DEVELOPMENTAL BIOLOGY

pMesogenin1and2function directly downstream ofXtbx6inXenopussomitogenesis and myogenesis

(2008) Shunsuke Tazumi et al.   DEVELOPMENTAL DYNAMICS

The T-box transcription factor Eomes/Tbr2 regulates neurogenesis in the cortical subventricular zone

(2008) S. J. Arnold et al.   GENES & DEVELOPMENT

Tbx3 promotes liver bud expansion during mouse development by suppression of cholangiocyte differentiation

(2008) Timo H.-W. Lüdtke et al.   HEPATOLOGY

Intermediate Progenitors in Adult Hippocampal Neurogenesis: Tbr2 Expression and Coordinate Regulation of Neuronal Output

(2008) R. D. Hodge et al.   JOURNAL OF NEUROSCIENCE

Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart

(2008) Bin Zhou et al.   NATURE

A myocardial lineage derives from Tbx18 epicardial cells

(2008) Chen-Leng Cai et al.   NATURE

Tbr2 Directs Conversion of Radial Glia into Basal Precursors and Guides Neuronal Amplification by Indirect Neurogenesis in the Developing Neocortex

(2008) Alessandro Sessa et al.   NEURON

Tbx6 Regulates Left/Right Patterning in Mouse Embryos through Effects on Nodal Cilia and Perinodal Signaling

(2008) Anna-Katerina Hadjantonakis et al.   PLoS One

Generation and Regeneration of Cells of the Liver and Pancreas

(2008) K. S. Zaret et al.   SCIENCE