Epigenetic methylations and their connections with metabolism

Tet family proteins and 5-hydroxymethylcytosine in development and disease

(2012) L. Tan et al.   DEVELOPMENT

Histone methylation: a dynamic mark in health, disease and inheritance

(2012) Eric L. Greer et al.   NATURE REVIEWS GENETICS

Functions of DNA methylation: islands, start sites, gene bodies and beyond

(2012) Peter A. Jones   NATURE REVIEWS GENETICS

Yin Yang 1 extends the Myc-related transcription factors network in embryonic stem cells

(2012) Pietro Vella et al.   NUCLEIC ACIDS RESEARCH

The H3K27 demethylase UTX-1 regulates C. elegans lifespan in a germline-independent, insulin-dependent manner

(2011) Travis J. Maures et al.   AGING CELL

The growing challenge of obesity and cancer: an inflammatory issue

(2011) Alison E. Harvey et al.   Annals of the New York Academy of Sciences

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

(2011) Wei Xu et al.   CANCER CELL

EZH2 Promotes Expansion of Breast Tumor Initiating Cells through Activation of RAF1-β-Catenin Signaling

(2011) Chun-Ju Chang et al.   CANCER CELL

Crosstalk between Components of Circadian and Metabolic Cycles in Mammals

(2011) Gad Asher et al.   Cell Metabolism

TET Family Proteins and Their Role in Stem Cell Differentiation and Transformation

(2011) Luisa Cimmino et al.   Cell Stem Cell

The complex transcription regulatory landscape of our genome: control in three dimensions

(2011) Erik Splinter et al.   EMBO JOURNAL

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

(2011) Rasheduzzaman Chowdhury et al.   EMBO REPORTS

Hypothesis: Environmental regulation of 5-hydroxymethylcytosine by oxidative stress

(2011) Nancy Chia et al.   Epigenetics

A dual epigenomic approach for the search of obesity biomarkers: DNA methylation in relation to diet-induced weight loss

(2011) Fermin I. Milagro et al.   FASEB JOURNAL

Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation

(2011) H. Wu et al.   GENES & DEVELOPMENT

Evolutionary diversity and developmental regulation of X-chromosome inactivation

(2011) Martin Escamilla-Del-Arenal et al.   HUMAN GENETICS

Pathophysiological Response to Hypoxia — From the Molecular Mechanisms of Malady to Drug Discovery: Epigenetic Regulation of the Hypoxic Response via Hypoxia-Inducible Factor and Histone Modifying Enzymes

(2011) Imari Mimura et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Landscape of TET2 mutations in acute myeloid leukemia

(2011) S Weissmann et al.   LEUKEMIA

Interplay between HDAC3 and WDR5 Is Essential for Hypoxia-Induced Epithelial-Mesenchymal Transition

(2011) Min-Zu Wu et al.   MOLECULAR CELL

Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans

(2011) Eric L. Greer et al.   NATURE

Dynamic interactions between transposable elements and their hosts

(2011) Henry L. Levin et al.   NATURE REVIEWS GENETICS

Determinants and dynamics of genome accessibility

(2011) Oliver Bell et al.   NATURE REVIEWS GENETICS

Forming functional fat: a growing understanding of adipocyte differentiation

(2011) Ana G. Cristancho et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Sustained Dietary Change Increases Epigenetic Variation in Isogenic Mice

(2011) Cheryl C. Y. Li et al.   PLoS Genetics

Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

(2010) Maria E. Figueroa et al.   CANCER CELL

Genetic Analysis of Transforming Events That Convert Chronic Myeloproliferative Neoplasms to Leukemias

(2010) O. Abdel-Wahab et al.   CANCER RESEARCH

A Region of the Human HOXD Cluster that Confers Polycomb-Group Responsiveness

(2010) Caroline J. Woo et al.   CELL

Structural insights into histone lysine demethylation

(2010) Haifeng Hou et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Epigenetic integration of environmental and genomic signals in honey bees: the critical interplay of nutritional, brain and reproductive networks

(2010) Ryszard Maleszka   Epigenetics

Epigenetics: The epicenter of the hypoxic response

(2010) Jenny A. Watson et al.   Epigenetics

Jarid2 and PRC2, partners in regulating gene expression

(2010) G. Li et al.   GENES & DEVELOPMENT

Histone Demethylase LSD1 Regulates Adipogenesis

(2010) Melina M. Musri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA-101 negatively regulates Ezh2 and its expression is modulated by androgen receptor and HIF-1α/HIF-1β

(2010) Paul Cao et al.   Molecular Cancer

Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans

(2010) Eric L. Greer et al.   NATURE

JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells

(2010) Diego Pasini et al.   NATURE

Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators

(2010) David Landeira et al.   NATURE CELL BIOLOGY

Chromatin structure and the inheritance of epigenetic information

(2010) Raphaël Margueron et al.   NATURE REVIEWS GENETICS

Active DNA demethylation: many roads lead to Rome

(2010) Susan C. Wu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Histone H3K27 methyltransferase Ezh2 represses Wnt genes to facilitate adipogenesis

(2010) L. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone demethylases in development and disease

(2010) Marianne Terndrup Pedersen et al.   TRENDS IN CELL BIOLOGY

GC-Rich Sequence Elements Recruit PRC2 in Mammalian ES Cells

(2010) Eric M. Mendenhall et al.   PLoS Genetics

Jarid2/Jumonji Coordinates Control of PRC2 Enzymatic Activity and Target Gene Occupancy in Pluripotent Cells

(2009) Jamy C. Peng et al.   CELL

Jumonji Modulates Polycomb Activity and Self-Renewal versus Differentiation of Stem Cells

(2009) Xiaohua Shen et al.   CELL

A Vertebrate Polycomb Response Element Governs Segmentation of the Posterior Hindbrain

(2009) Angela Sing et al.   CELL

HIF-1: upstream and downstream of cancer metabolism

(2009) Gregg L Semenza   CURRENT OPINION IN GENETICS & DEVELOPMENT

Histone H3 lysine 4 (H3K4) methylation in development and differentiation

(2009) Joel C. Eissenberg et al.   DEVELOPMENTAL BIOLOGY

Bmi-1 regulates the Ink4a/Arf locus to control pancreatic  -cell proliferation

(2009) S. Dhawan et al.   GENES & DEVELOPMENT

Polycomb protein Ezh2 regulates pancreatic  -cell Ink4a/Arf expression and regeneration in diabetes mellitus

(2009) H. Chen et al.   GENES & DEVELOPMENT

Regulation of the Histone Demethylase JMJD1A by Hypoxia-Inducible Factor 1  Enhances Hypoxic Gene Expression and Tumor Growth

(2009) A. J. Krieg et al.   MOLECULAR AND CELLULAR BIOLOGY

Protein Arginine Methylation in Mammals: Who, What, and Why

(2009) Mark T. Bedford et al.   MOLECULAR CELL

ASCOM Controls Farnesoid X Receptor Transactivation through Its Associated Histone H3 Lysine 4 Methyltransferase Activity

(2009) Dae-Hwan Kim et al.   MOLECULAR ENDOCRINOLOGY

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE

Role of Jhdm2a in regulating metabolic gene expression and obesity resistance

(2009) Keisuke Tateishi et al.   NATURE

In Brief

(2009)   NATURE REVIEWS NEUROSCIENCE

Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis

(2009) X. Xia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1 

(2009) S. Zhao et al.   SCIENCE

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

(2009) M. Tahiliani et al.   SCIENCE

Hypoxia upregulates the histone demethylase JMJD1A via HIF-1

(2008) Sven Wellmann et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1α

(2008) Patrick J. Pollard et al.   BIOCHEMICAL JOURNAL

Epigenetic Control of rDNA Loci in Response to Intracellular Energy Status

(2008) Akiko Murayama et al.   CELL

A Metabolic Throttle Regulates the Epigenetic State of rDNA

(2008) Ingrid Grummt et al.   CELL

Role of the Lysine-Specific Demethylase 1 in the Proinflammatory Phenotype of Vascular Smooth Muscle Cells of Diabetic Mice

(2008) Marpadga A. Reddy et al.   CIRCULATION RESEARCH

dKDM2 couples histone H2A ubiquitylation to histone H3 demethylation during Polycomb group silencing

(2008) A. Lagarou et al.   GENES & DEVELOPMENT

The Histone Demethylases JMJD1A and JMJD2B Are Transcriptional Targets of Hypoxia-inducible Factor HIF

(2008) Sophie Beyer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activating Signal Cointegrator-2 Is an Essential Adaptor to Recruit Histone H3 Lysine 4 Methyltransferases MLL3 and MLL4 to the Liver X Receptors

(2008) Seunghee Lee et al.   MOLECULAR ENDOCRINOLOGY

Hypoxia induces a novel signature of chromatin modifications and global repression of transcription

(2008) Amber Buescher Johnson et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Epigenetic transcriptional repression of cellular genes by a viral SET protein

(2008) Shiraz Mujtaba et al.   NATURE CELL BIOLOGY

De novo DNA methylation promoted by G9a prevents reprogramming of embryonically silenced genes

(2008) Silvina Epsztejn-Litman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis

(2008) J. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic histone H3 lysine 9 methylation in metabolic memory and inflammatory phenotype of vascular smooth muscle cells in diabetes

(2008) Louisa M. Villeneuve et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nutritional Control of Reproductive Status in Honeybees via DNA Methylation

(2008) R. Kucharski et al.   SCIENCE

A translational view on the biliary lipid secretory network

(2007) Giuseppe Lo Sasso et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS