Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 69, Issue 18, Pages 3015-3026Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-012-0963-z
Keywords
CD98; Integrin signaling; Amino acid transport; Cell homeostasis; Immune response
Categories
Funding
- Department of Veterans Affairs
- National Institutes of Health of Diabetes and Digestive and Kidney [RO1-DK-071594]
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The transmembrane glycoprotein CD98 is a potential regulator of multiple functions, including integrin signaling and amino acid transport. Abnormal expression or function of CD98 and disruption of the interactions between CD98 and its binding partners result in defects in cell homeostasis and immune responses. Indeed, expression of CD98 has been correlated with diseases such as inflammation and tumor metastasis. Modulation of CD98 expression and/or function therefore represents a promising therapeutic strategy for the treatment and prevention of such pathologies. Herein, we review the role of CD98 with focus on its functional importance in homeostasis and immune responses, which could help to better understand the pathogenesis of CD98-associated diseases.
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