Ca2+ release-activated Ca2+ (CRAC) current, structure, and function

Surf4 modulates STIM1-dependent calcium entry

(2012) Yoko Fujii et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SARAF Inactivates the Store Operated Calcium Entry Machinery to Prevent Excess Calcium Refilling

(2012) Raz Palty et al.   CELL

Junctate is a Ca2+-sensing structural component of Orai1 and stromal interaction molecule 1 (STIM1)

(2012) S. Srikanth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and mechanistic insights into the activation of Stromal interaction molecule 1 (STIM1)

(2012) X. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct Binding Between Orai1 and AC8 Mediates Dynamic Interplay Between Ca2+ and cAMP Signaling

(2012) D. Willoughby et al.   Science Signaling

STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation

(2011) Martin Muik et al.   EMBO JOURNAL

Local Cytosolic Ca2+Elevations Are Required for Stromal Interaction Molecule 1 (STIM1) De-oligomerization and Termination of Store-operated Ca2+Entry

(2011) Wei-Wei Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cooperativeness of Orai Cytosolic Domains Tunes Subtype-specific Gating

(2011) Irene Frischauf et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Determinants within N Terminus of Orai3 Protein That Control Channel Activation and Gating

(2011) Judith Bergsmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Third Transmembrane Segment of Orai1 Protein Modulates Ca2+Release-activated Ca2+(CRAC) Channel Gating and Permeation Properties

(2011) Sonal Srikanth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia-induced Acidosis Uncouples the STIM-Orai Calcium Signaling Complex

(2011) Salvatore Mancarella et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The crystal structure of a voltage-gated sodium channel

(2011) Jian Payandeh et al.   NATURE

Temperature-dependent STIM1 activation induces Ca2+ influx and modulates gene expression

(2011) Bailong Xiao et al.   Nature Chemical Biology

Sensing cellular stress through STIM proteins

(2011) Jonathan Soboloff et al.   Nature Chemical Biology

The Physiological Function of Store-operated Calcium Entry

(2011) James W. Putney   NEUROCHEMICAL RESEARCH

Stoichiometric requirements for trapping and gating of Ca2+release-activated Ca2+(CRAC) channels by stromal interaction molecule 1 (STIM1)

(2011) Paul J. Hoover et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations in Orai1 transmembrane segment 1 cause STIM1-independent activation of Orai1 channels at glycine 98 and channel closure at arginine 91

(2011) S. L. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Basis of Calcium Signaling in Lymphocytes: STIM and ORAI

(2010) Patrick G. Hogan et al.   Annual Review of Immunology

A Basic Sequence in STIM1 Promotes Ca2+Influx by Interacting with the C-Terminal Acidic Coiled Coil of Orai1

(2010) Nathaniel Calloway et al.   BIOCHEMISTRY

The role of store-operated calcium influx in skeletal muscle signaling

(2010) Jonathan A. Stiber et al.   CELL CALCIUM

Graded activation of CRAC channel by binding of different numbers of STIM1 to Orai1 subunits

(2010) Zhengzheng Li et al.   CELL RESEARCH

Resting State Orai1 Diffuses as Homotetramer in the Plasma Membrane of Live Mammalian Cells

(2010) Josef Madl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

S-glutathionylation activates STIM1 and alters mitochondrial homeostasis

(2010) Brian J. Hawkins et al.   JOURNAL OF CELL BIOLOGY

A single lysine in the N-terminal region of store-operated channels is critical for STIM1-mediated gating

(2010) Annette Lis et al.   JOURNAL OF GENERAL PHYSIOLOGY

Essential Role for the CRAC Activation Domain in Store-dependent Oligomerization of STIM1

(2010) Elizabeth D. Covington et al.   MOLECULAR BIOLOGY OF THE CELL

Pore architecture of the ORAI1 store-operated calcium channel

(2010) Y. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of STIM1-Orai1 Involves an Intramolecular Switching Mechanism

(2010) M. K. Korzeniowski et al.   Science Signaling

A minimal regulatory domain in the C terminus of STIM1 binds to and activates ORAI1 CRAC channels

(2009) Takumi Kawasaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

STIM1 Clusters and Activates CRAC Channels via Direct Binding of a Cytosolic Domain to Orai1

(2009) Chan Young Park et al.   CELL

An EB1-Binding Motif Acts as a Microtubule Tip Localization Signal

(2009) Srinivas Honnappa et al.   CELL

Small-Molecule Inhibitors of Store-Operated Calcium Entry

(2009) Zachary K. Sweeney et al.   ChemMedChem

The molecular physiology of CRAC channels

(2009) Murali Prakriya   IMMUNOLOGICAL REVIEWS

A Cytosolic Homomerization and a Modulatory Domain within STIM1 C Terminus Determine Coupling to ORAI1 Channels

(2009) Martin Muik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Intracellular Loop of Orai1 Plays a Central Role in Fast Inactivation of Ca2+Release-activated Ca2+Channels

(2009) Sonal Srikanth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Ca2+Release-activated Ca2+(CRAC) Modulatory Domain (CMD) within STIM1 Mediates Fast Ca2+-dependent Inactivation of ORAI1 Channels

(2009) Isabella Derler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tetrameric Orai1 Is a Teardrop-shaped Molecule with a Long, Tapered Cytoplasmic Domain

(2009) Yuusuke Maruyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased Hydrophobicity at the N Terminus/Membrane Interface Impairs Gating of the Severe Combined Immunodeficiency-related ORAI1 Mutant

(2009) Isabella Derler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Determinants of the Coupling between STIM1 and Orai Channels

(2009) Irene Frischauf et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Properties of Orai1 mediated store-operated current depend on the expression levels of STIM1 and Orai1 proteins

(2009) N. Scrimgeour et al.   JOURNAL OF PHYSIOLOGY-LONDON

SOAR and the polybasic STIM1 domains gate and regulate Orai channels

(2009) Joseph P. Yuan et al.   NATURE CELL BIOLOGY

STIM1 gates the store-operated calcium channel ORAI1 in vitro

(2009) Yubin Zhou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular determinants of fast Ca2+-dependent inactivation and gating of the Orai channels

(2009) K. P. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STIM1 and calmodulin interact with Orai1 to induce Ca2+-dependent inactivation of CRAC channels

(2009) F. M. Mullins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural determinants of ion permeation in CRAC channels

(2009) Beth A. McNally et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasticity in Ca2+ selectivity of Orai1/Orai3 heteromeric channel

(2009) R. Schindl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biophysical characterization of the EF-hand and SAM domain containing Ca2+ sensory region of STIM1 and STIM2

(2008) Le Zheng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structural and Mechanistic Insights into STIM1-Mediated Initiation of Store-Operated Calcium Entry

(2008) Peter B. Stathopulos et al.   CELL

STIM1 Is a MT-Plus-End-Tracking Protein Involved in Remodeling of the ER

(2008) Ilya Grigoriev et al.   CURRENT BIOLOGY

2-Aminoethoxydiphenyl Borate Alters Selectivity of Orai3 Channels by Increasing Their Pore Size

(2008) Rainer Schindl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stromal Interaction Molecule (STIM) 1 and STIM2 Calcium Sensing Regions Exhibit Distinct Unfolding and Oligomerization Kinetics

(2008) Peter B. Stathopulos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamic Coupling of the Putative Coiled-coil Domain of ORAI1 with STIM1 Mediates ORAI1 Channel Activation

(2008) Martin Muik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complex Actions of 2-Aminoethyldiphenyl Borate on Store-operated Calcium Entry

(2008) Wayne I. DeHaven et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytosolic Ca2+ prevents the subplasmalemmal clustering of STIM1: an intrinsic mechanism to avoid Ca2+ overload

(2008) R. Malli et al.   JOURNAL OF CELL SCIENCE

Ca2+-store-dependent and -independent reversal of Stim1 localization and function

(2008) J. T. Smyth et al.   JOURNAL OF CELL SCIENCE

STIM1-Orai1 interactions and Orai1 conformational changes revealed by live-cell FRET microscopy

(2008) Laura Navarro-Borelly et al.   JOURNAL OF PHYSIOLOGY-LONDON

Ca2+microdomains near plasma membrane Ca2+channels: impact on cell function

(2008) Anant B. Parekh   JOURNAL OF PHYSIOLOGY-LONDON

Dynamic Movement of the Calcium Sensor STIM1 and the Calcium Channel Orai1 in Activated T-Cells: Puncta and Distal Caps

(2008) Valarie A. Barr et al.   MOLECULAR BIOLOGY OF THE CELL

Molecular Clustering of STIM1 with Orai1/CRACM1 at the Plasma Membrane Depends Dynamically on Depletion of Ca2+ Stores and on Electrostatic Interactions

(2008) Nathaniel Calloway et al.   MOLECULAR BIOLOGY OF THE CELL

The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers

(2008) Aubin Penna et al.   NATURE

Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation

(2008) Riina M. Luik et al.   NATURE

Functional stoichiometry of the unitary calcium-release-activated calcium channel

(2008) W. Ji et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Orai1 subunit stoichiometry of the mammalian CRAC channel pore

(2007) Olivier Mignen et al.   JOURNAL OF PHYSIOLOGY-LONDON