PGC-1α: a master gene that is hard to master

Mitochondrial Biology and Parkinson's Disease

(2013) C. Perier et al.   Cold Spring Harbor Perspectives in Medicine

Sustained expression of PGC-1  in the rat nigrostriatal system selectively impairs dopaminergic function

(2012) C. Ciron et al.   HUMAN MOLECULAR GENETICS

PARIS (ZNF746) Repression of PGC-1α Contributes to Neurodegeneration in Parkinson's Disease

(2011) Joo-Ho Shin et al.   CELL

Transgenic expression and activation of PGC-1α protect dopaminergic neurons in the MPTP mouse model of Parkinson’s disease

(2011) Giuseppa Mudò et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Peroxisome proliferator activator receptor gamma coactivator-1alpha (PGC-1α) improves motor performance and survival in a mouse model of amyotrophic lateral sclerosis

(2011) Wei Zhao et al.   Molecular Neurodegeneration

PGC-1α protects neurons and alters disease progression in an amyotrophic lateral sclerosis mouse model

(2011) Huiyun Liang et al.   MUSCLE & NERVE

Astrocytes from familial and sporadic ALS patients are toxic to motor neurons

(2011) Amanda M Haidet-Phillips et al.   NATURE BIOTECHNOLOGY

Neuronal Inactivation of Peroxisome Proliferator-activated Receptor γ Coactivator 1α (PGC-1α) Protects Mice from Diet-induced Obesity and Leads to Degenerative Lesions

(2010) Di Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PGC-1 , A Potential Therapeutic Target for Early Intervention in Parkinson's Disease

(2010) B. Zheng et al.   Science Translational Medicine

PGC-1α and PGC-1β Regulate Mitochondrial Density in Neurons

(2009) Przemyslaw Wareski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Paradoxical effects of increased expression of PGC-1  on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism

(2008) C. S. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis

(2008) Claire Henchcliffe et al.   Nature clinical practice. Neurology