Exogenous or endogenous Toll-like receptor ligands: which is the MVP in tumorigenesis?

Reduced expression of Toll-like receptor 4 inhibits human breast cancer cells proliferation and inflammatory cytokines secretion

(2012) Huan Yang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Peroxiredoxin 1 Controls Prostate Cancer Growth through Toll-Like Receptor 4-Dependent Regulation of Tumor Vasculature

(2011) J. R. Riddell et al.   CANCER RESEARCH

Activation of Toll-like Receptor 5 on Breast Cancer Cells by Flagellin Suppresses Cell Proliferation and Tumor Growth

(2011) Z. Cai et al.   CANCER RESEARCH

LPS-Induced TLR4 Signaling in Human Colorectal Cancer Cells Increases  1 Integrin-Mediated Cell Adhesion and Liver Metastasis

(2011) R. Y. C. Hsu et al.   CANCER RESEARCH

TLR-3 polymorphism is an independent prognostic marker for stage II colorectal cancer

(2011) F.A. Castro et al.   EUROPEAN JOURNAL OF CANCER

Toll-like receptor-3 as a target to enhance bioactivity of cancer immunotherapy

(2010) Christopher F. Nicodemus et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Study of TLR3, TLR4 and TLR9 in breast carcinomas and their association with metastasis

(2010) Salomé González-Reyes et al.   BMC CANCER

Toll-Like Receptor (TLR) and Nucleosome-binding Oligomerization Domain (NOD) gene polymorphisms and endometrial cancer risk

(2010) Katie A Ashton et al.   BMC CANCER

The role of prostaglandin E2 (PGE 2) in toll-like receptor 4 (TLR4)-mediated colitis-associated neoplasia

(2010) Yasmin Hernandez et al.   BMC GASTROENTEROLOGY

Toll-like receptor 2 is present in the microenvironment of oral squamous cell carcinoma

(2010) L K Ng et al.   BRITISH JOURNAL OF CANCER

High expression of Toll-like receptor 4/myeloid differentiation factor 88 signals correlates with poor prognosis in colorectal cancer

(2010) E L Wang et al.   BRITISH JOURNAL OF CANCER

Expression of toll-like receptor 4 is down-regulated during progression of cervical neoplasia

(2010) Li Yu et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Study of TLR3, TLR4, and TLR9 in prostate carcinomas and their association with biochemical recurrence

(2010) Salomé González-Reyes et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Toll-like Receptor 3–Mediated Suppression of TRAMP Prostate Cancer Shows the Critical Role of Type I Interferons in Tumor Immune Surveillance

(2010) Arnold I. Chin et al.   CANCER RESEARCH

Therapeutic Targeting of TLR9 Inhibits Cell Growth and Induces Apoptosis in Neuroblastoma

(2010) C. Brignole et al.   CANCER RESEARCH

Persistent Cyclooxygenase-2 Inhibition Downregulates NF-κB, Resulting in Chronic Intestinal Inflammation in the Min/+ Mouse Model of Colon Tumorigenesis

(2010) Adelaide M. Carothers et al.   CANCER RESEARCH

Opposing Effects of Toll-like Receptor (TLR3) Signaling in Tumors Can Be Therapeutically Uncoupled to Optimize the Anticancer Efficacy of TLR3 Ligands

(2010) R. Conforti et al.   CANCER RESEARCH

Toll-like receptor 9 expression in breast and ovarian cancer is associated with poorly differentiated tumors

(2010) Regina Berger et al.   CANCER SCIENCE

TLR4-mediated skin carcinogenesis is dependent on immune and radioresistant cells

(2010) Deepak Mittal et al.   EMBO JOURNAL

Toll-like receptor (TLR) 7 and TLR8 expression on CD133+ cells in colorectal cancer points to a specific role for inflammation-induced TLRs in tumourigenesis and tumour progression

(2010) Martin Grimm et al.   EUROPEAN JOURNAL OF CANCER

Expression of Toll-like receptor 9 in bone marrow cells of myelodysplastic syndromes is down-regulated during transformation to overt leukemia

(2010) Nobuo Kuninaka et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Endotoxin accumulation prevents carcinogen-induced apoptosis and promotes liver tumorigenesis in rodents

(2010) Le-Xing Yu et al.   HEPATOLOGY

Constitutive activation of epithelial TLR4 augments inflammatory responses to mucosal injury and drives colitis-associated tumorigenesis

(2010) Masayuki Fukata et al.   INFLAMMATORY BOWEL DISEASES

The tumor microenvironment of colorectal cancer: stromal TLR-4 expression as a potential prognostic marker

(2010) Rosaria Cammarota et al.   Journal of Translational Medicine

Significant association between toll-like receptor gene polymorphisms and gallbladder cancer

(2010) Kshitij Srivastava et al.   LIVER INTERNATIONAL

Oncogenically active MYD88 mutations in human lymphoma

(2010) Vu N. Ngo et al.   NATURE

Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands

(2010) Xiaoxia Z. West et al.   NATURE

Pancreatic adenocarcinoma upregulated factor promotes metastasis by regulating TLR/CXCR4 activation

(2010) H D Park et al.   ONCOGENE

Activation of PAR2 or/and TLR4 promotes SW620 cell proliferation and migration via phosphorylation of ERK1/2

(2010) Zhou   ONCOLOGY REPORTS

Bacteria Peptidoglycan Promoted Breast Cancer Cell Invasiveness and Adhesiveness by Targeting Toll-Like Receptor 2 in the Cancer Cells

(2010) Wenjie Xie et al.   PLoS One

Toll-Like Receptor 2 Signaling Protects Mice from Tumor Development in a Mouse Model of Colitis-Induced Cancer

(2010) Emily L. Lowe et al.   PLoS One

Expression of toll-like receptor-9 is increased in poorly differentiated prostate tumors

(2010) Marja-Riitta Väisänen et al.   PROSTATE

CXCR4/SDF-1 pathway is crucial for TLR9 agonist enhanced metastasis of human lung cancer cell

(2009) Lin Xu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Toll-like receptor 9 agonists promote IL-8 and TGF-β1production via activation of nuclear factor κB in PC-3 cells

(2009) Jin-ming Di et al.   CANCER GENETICS AND CYTOGENETICS

The association between Toll-like receptor 4 (TLR4) polymorphisms and the risk of prostate cancer in Korean men

(2009) Jaemann Song et al.   CANCER GENETICS AND CYTOGENETICS

Toll-like Receptors 3 and 7 Agonists Enhance Tumor Cell Lysis by Human    T Cells

(2009) H. Shojaei et al.   CANCER RESEARCH

Triggering of Toll-like Receptor 4 Expressed on Human Head and Neck Squamous Cell Carcinoma Promotes Tumor Development and Protects the Tumor from Immune Attack

(2009) M. J. Szczepanski et al.   CANCER RESEARCH

RETRACTED ARTICLE: CD14 Promoter-159 Polymorphism Is Associated with Reduced Risk of Intestinal-Type Gastric Cancer in a Japanese Population

(2009) Tomomitsu Tahara et al.   DIGESTIVE DISEASES AND SCIENCES

Impact of Toll-like receptors [TLR] 2 (−196 to −174 del) and TLR 4 (Asp299Gly, Thr399Ile) in cervical cancer susceptibility in North Indian women

(2009) Saumya Pandey et al.   GYNECOLOGIC ONCOLOGY

Toll-Like Receptor 4 +3725 G/C Polymorphism,Helicobacter pyloriSeropositivity, and the Risk of Gastric Atrophy and Gastric Cancer in Japanese

(2009) Asahi Hishida et al.   HELICOBACTER

Resistin competes with lipopolysaccharide for binding to toll-like receptor 4

(2009) Andrej Tarkowski et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Polymorphisms and haplotypes in TLR9 and MYD88 are associated with the development of Hodgkin's lymphoma: a candidate–gene association study

(2009) Vassiliki Mollaki et al.   JOURNAL OF HUMAN GENETICS

Peroxiredoxin 1 Stimulates Secretion of Proinflammatory Cytokines by Binding to TLR4

(2009) J. R. Riddell et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Cardiac Myosin Activates Innate Immune Responses through TLRs

(2009) P. Zhang et al.   JOURNAL OF IMMUNOLOGY

Toll-like Receptor 4 Signaling Promotes Tumor Growth

(2009) Che-Hsin Lee et al.   JOURNAL OF IMMUNOTHERAPY

Toll-like receptor 9 agonists up-regulates the expression of cyclooxygenase-2 via activation of NF-κB in prostate cancer cells

(2009) Jin Ming Di et al.   MOLECULAR BIOLOGY REPORTS

Small interfering RNA-directed targeting of Toll-like receptor 4 inhibits human prostate cancer cell invasion, survival, and tumorigenicity

(2009) Dong Hua et al.   MOLECULAR IMMUNOLOGY

Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis

(2009) Sunhwa Kim et al.   NATURE

Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease

(2009) Kim Midwood et al.   NATURE MEDICINE

TLR4 signaling induced by lipopolysaccharide or paclitaxel regulates tumor survival and chemoresistance in ovarian cancer

(2009) M Szajnik et al.   ONCOGENE

Expression of Toll-like receptor 4 in the prostate gland and its association with the severity of prostate cancer

(2009) Gerardo Gatti et al.   PROSTATE

Functionally Active Toll-Like Receptor 3 on Human Primary and Metastatic Cancer Cells

(2009) T. Matijevic et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

HMGB1 Mediates Endogenous TLR2 Activation and Brain Tumor Regression

(2009) James F Curtin et al.   PLOS MEDICINE

Toll-like receptors: lessons to learn from normal and malignant human B cells

(2008) D. Chiron et al.   BLOOD

Protective Role of Toll-like Receptor 4 during the Initiation Stage of Cutaneous Chemical Carcinogenesis

(2008) N. Yusuf et al.   CANCER RESEARCH

A pooled investigation of Toll-like receptor gene variants and risk of non-Hodgkin lymphoma

(2008) Mark P. Purdue et al.   CARCINOGENESIS

Toll-like receptor 3 triggers apoptosis of human prostate cancer cells through a PKC- -dependent mechanism

(2008) A. Paone et al.   CARCINOGENESIS

RAGE, carboxylated glycans and S100A8/A9 play essential roles in colitis-associated carcinogenesis

(2008) Olga Turovskaya et al.   CARCINOGENESIS

Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury

(2008) Yumiko Imai et al.   CELL

TLR4 signaling promotes the expression of VEGF and TGFβ 1 in human prostate epithelial PC3 cells induced by lipopolysaccharide

(2008) Zengyang Pei et al.   CELLULAR IMMUNOLOGY

Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms in gastric cancer of intestinal and diffuse histotypes

(2008) D. Santini et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Toll-Like Receptor 5 Engagement Modulates Tumor Development and Growth in a Mouse Xenograft Model of Human Colon Cancer

(2008) Sang Hoon Rhee et al.   GASTROENTEROLOGY

Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein

(2008) Pingyan Cheng et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Toll-Like Receptor 9 Mediates CpG Oligonucleotide-Induced Cellular Invasion

(2008) J. M. Ilvesaro et al.   MOLECULAR CANCER RESEARCH

The S100A8–serum amyloid A3–TLR4 paracrine cascade establishes a pre-metastatic phase

(2008) Sachie Hiratsuka et al.   NATURE CELL BIOLOGY

The Use of TLR7 and TLR8 Ligands for the Enhancement of Cancer Immunotherapy

(2008) E. L. J. M. Smits et al.   ONCOLOGIST

Akt2 overexpression plays a critical role in the establishment of colorectal cancer metastasis

(2008) P. G. Rychahou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence for the Pivotal Role of Endogenous Toll-Like Receptor 4 Ligands in Liver Ischemia and Reperfusion Injury

(2008) Yuan Zhai et al.   TRANSPLANTATION

Hyaluronan fragments induce cytokine and metalloprotease upregulation in human melanoma cells in part by signalling via TLR4

(2007) Verena Voelcker et al.   EXPERIMENTAL DERMATOLOGY