Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 68, Issue 23, Pages 3815-3821Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-011-0755-x
Keywords
TRPC; Calcium; Endothelial cells; Growth cone; Angiogenesis; Axon guidance
Categories
Funding
- National Basic Research Program of China [2011CBA00400, 2006CB806605]
- State Key Research Program of China [2006CB943802]
- Shanghai government [06dj14010, 07pj14107]
- Chinese Academy of Sciences
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Wiring of vascular and neural networks requires precise guidance of growing blood vessels and axons, respectively, to reach their targets during development. Both of the processes share common molecular signaling pathways. Transient receptor potential canonical (TRPC) channels are calcium-permeable cation channels and gated via receptor- or store-operated mechanisms. Recent studies have revealed the requirement of TRPC channels in mediating guidance cue-induced calcium influx and their essential roles in regulating axon navigation and angiogenesis. Dissecting TRPC functions in these physiological processes may provide therapeutic implications for suppressing pathological angiogenesis and improving nerve regeneration.
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