Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 66, Issue 21, Pages 3403-3420Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-009-0095-2
Keywords
Stem cell; Pluripotency; Differentiation; Non-coding RNA; Reprogramming; Cancer; Germ cell
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Funding
- Deutsche Forschungsgemeinschaft (DFG)
- Pluripotency and Cellular Reprogramming [ED79/1-1]
- German Ministry of Education and Research (BMBF) [01 GN 0813]
- Medical Faculty of the University of Bonn
- [SPP1356]
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Stem cells provide fascinating prospects for biomedical applications by combining the ability to renew themselves and to differentiate into specialized cell types. Since the first isolation of embryonic stem (ES) cells about 30 years ago, there has been a series of groundbreaking discoveries that have the potential to revolutionize modern life science. For a long time, embryos or germ cell-derived cells were thought to be the only source of pluripotency-a dogma that has been challenged during the last decade. Several findings revealed that cell differentiation from (stem) cells to mature cells is not in fact an irreversible process. The molecular mechanism underlying cellular reprogramming is poorly understood thus far. Identifying how pluripotency maintenance takes place in ES cells can help us to understand how pluripotency induction is regulated. Here, we review recent advances in the field of stem cell regulation focusing on key transcription factors and their functional interplay with non-coding RNAs.
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