Article
Genetics & Heredity
Leah F. Rosin, Jose Gil, Ines A. Drinnenberg, Elissa P. Lei
Summary: Accurate chromosome segregation is crucial for reproductive success. The use of Oligopaints in the silkworm Bombyx mori has provided new insights into mechanisms of homolog pairing during meiosis, revealing asynchronous pairing, transcription-biased pairing in males, and similarities in bivalent formation with C. elegans. Furthermore, the study suggests that microtubule recruitment may be dependent on kinetochore proteins but independent of centromeres, and that telomeres play a central role in regulating chromosome interactions during sperm and egg development.
Article
Biochemical Research Methods
Erik J. Navarro, Wallace F. Marshall, Jennifer C. Fung
Summary: During meiosis, homologous chromosomes must quickly pair up while mitigating and resolving interlocks. The active motion of telomeres speeds up pairing, while an increase in nuclear size slows down pairing but reduces the number of interlocks significantly.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Byeong Seong Ki, Sung Han Shim, Chanhyeok Park, Hyunjin Yoo, Hyeonwoo La, Ok-Hee Lee, Youngjoo Kwon, David G. Skalnik, Yuki Okada, Ho-Geun Yoon, Jin-Hoi Kim, Kwonho Hong, Youngsok Choi
Summary: A protein called Cfp1 has been found to play an important role in the development of sperm cells in mice. Its absence interferes with the process of meiosis, which leads to abnormal sperm formation. Cfp1 controls gene expression, including genes related to meiosis and homologous recombination.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Chuizheng Kong, Guangyao Zhao, Lifeng Gao, Xiuying Kong, Daowen Wang, Xu Liu, Jizeng Jia
Summary: In this study, the association between transposons (TEs), chromatin states, and chromatin accessibility in Aegilops tauschii was analyzed. It was found that TEs contributed to the diverse distribution of chromatin states and affected the chromatin state and openness of potential regulatory elements. Some TE superfamilies carried active/open chromatin regions. Furthermore, the accessibility shaped by TEs was associated with the histone mark H3K9ac. These findings highlight the role of TEs in shaping the epigenetic landscape and regulating gene expression in Aegilops tauschii.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Plant Sciences
Jie Liu, Meng Ke, Yuhan Sun, Shihui Niu, Wenli Zhang, Yun Li
Summary: Plant rejuvenation involves resetting gene expression patterns, chromatin remodeling, and histone modifications, resulting in the restoration of juvenile characteristics. The epigenetic mechanisms underlying this process are still in the early stages of study.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Review
Cell Biology
Shihang Zhou, Hongliang Zeng, Jinhua Huang, Li Lei, Xiaoliang Tong, Si Li, Ying Zhou, Haoran Guo, Manal Khan, Liping Luo, Rong Xiao, Jing Chen, Qinghai Zeng
Summary: Melanogenesis is a complex process involving multiple genes and signaling pathways, with epigenetics playing a key role in regulating the expression of key genes. Epigenetic-based therapy provides novel opportunities for treating dermatoses caused by pigmentation disturbances.
AGEING RESEARCH REVIEWS
(2021)
Review
Gastroenterology & Hepatology
Vivienne Woo, Theresa Alenghat
Summary: The complex relationship between the gastrointestinal tract and microbiota is regulated by epigenetic modifications, including modifications to DNA or histones and regulation of non-coding RNAs. Further research is needed to fully understand the mechanisms of epigenetic regulation.
Review
Cell Biology
Qin Peng, Kegui Weng, Shitian Li, Richard Xu, Yingxiao Wang, Yongzhong Wu
Summary: Radiation therapy has been used as a tumoricidal modality for over a century in the United States, affecting a large number of patients annually. The biological mechanisms of radiation remain unclear, emphasizing the importance of understanding this to enhance tumor killing effects and minimize normal cell side effects. Various studies have shown how DNA breaks and epigenetic remodeling can be affected by radiotherapy, suggesting the potential modulation of histone modification enzymes to influence the radiosensitivity of cancer cells. Efforts are being made to explore the combination of epigenetic drugs and radiotherapy in limited cancer types but further research is needed to fully understand the mechanisms behind radiation-induced epigenetic regulation and chromatin remodeling.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Genetics & Heredity
Miguel Hernandez Sanchez-Rebato, Alida M. Bouatta, Maria E. Gallego, Charles I. White, Olivier Da Ines
Summary: RAD54 protein plays a crucial role in repairing meiotic double strand breaks by RAD51 in the plant Arabidopsis thaliana, particularly in the absence of DMC1. Its function in meiosis is mainly downstream of the support provided by RAD51 to DMC1 activity. These findings provide new insights into the regulation of homologous recombination in plants.
Article
Multidisciplinary Sciences
Xin-jie Zhuang, Xue Feng, Wen-hao Tang, Jin-liang Zhu, Ming Li, Jun-sheng Li, Xiao-ying Zheng, Rong Li, Ping Liu, Jie Qiao
Summary: FAM9B is a novel meiosis-associated protein co-localized with SYCP3 and gamma H2AX, playing a potential role in SC formation and DNA recombination during meiosis.
Article
Biochemistry & Molecular Biology
James H. Crichton, James M. Dunce, Orla M. Dunne, Lucy J. Salmon, Paul S. Devenney, Jennifer Lawson, Ian R. Adams, Owen R. Davies
Summary: During meiosis, the synaptonemal complex (SC), a supramolecular protein structure, forms between homologous chromosomes to aid in recombination. In mammals, SC formation involves the hierarchical assembly of an SYCP1 protein lattice. However, our study shows that the CE protein SYCE3 actively remodels the SYCP1 lattice during synapsis, rather than stabilizing it. SYCE3 interacts with other CE complexes and establishes a new lattice, leading to long-range synapsis and the formation of a mature SC.
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2023)
Article
Plant Sciences
Maria Vaquero-Sedas, Miguel A. Vega-Palas
Summary: Telomeric regions in Arabidopsis have a bimodal chromatin structure, with telomeres lacking both euchromatic and heterochromatic marks, followed by heterochromatic subtelomeres. The presence of heterochromatic modifications in subtelomeres may play a significant role in telomere biology.
Review
Cell Biology
Matin Miryeganeh
Summary: Senescence is a major developmental transition in plants that involves gene reprogramming and multilevel regulation. Transcription factors and epigenetic mechanisms play crucial roles in senescence-related genes, in addition to genetic reprogramming.
Article
Genetics & Heredity
Laia Marin-Gual, Laura Gonzalez-Rodelas, Gala Pujol, Covadonga Vara, Marta Martin-Ruiz, Soledad Berrios, Raul Fernandez-Donoso, Andrew Pask, Marilyn B. Renfree, Jesus Page, Paul D. Waters, Aurora Ruiz-Herrera
Summary: The study reveals the features of meiotic cell division in marsupials, particularly the strategies of sex chromosome pairing, recombination, and telomere homeostasis. The researchers found that marsupials have non-canonical meiotic strategies, including alternative mechanisms for controlling telomere length in the paternal parent. These findings provide new insights into the diversity of meiotic strategies in mammals.
Article
Genetics & Heredity
Qi Wang, Yonghe Wu, Tim Vorberg, Roland Eils, Carl Herrmann
Summary: Regulation of gene expression through multiple epigenetic components is a complex process that can have downstream effects on tumor suppressor or oncogenes. The IRENE software tool quantitatively analyzes differential epigenetic modifications and successfully identifies known cancer genes through network-based approaches.
FRONTIERS IN GENETICS
(2021)
Article
Cell Biology
Nayeli Torres-Ramirez, Maria L. Escobar, Gerardo H. Vazquez-Nin, Rosario Ortiz, Olga M. Echeverria
DEVELOPMENT GROWTH & DIFFERENTIATION
(2016)
Correction
Biochemistry & Molecular Biology
Hiroki Shibuya, Abrahan Hernandez-Hernandez, Akihiro Morimoto, Lumi Negishi, Christer Hoog, Yoshinori Watanabe
Article
Cell Biology
Ana Agostinho, Anna Kouznetsova, Abrahan Hernaprimendez-Hernaprimendez, Kristoffer Bernhem, Hans Blom, Hjalmar Brismar, Christer Hoog
JOURNAL OF CELL SCIENCE
(2018)
Article
Toxicology
Monika Garrido-Armas, Juan Carlos Corona, Maria Luisa Escobar, Leda Torres, Francisco Ordonez-Romero, Abrahan Hernandez-Hernandez, Francisco Arenas-Huertero
TOXICOLOGY IN VITRO
(2018)
Article
Anatomy & Morphology
Maria L. Escobar, Olga M. Echeverria, Yunuen M. Valenzuela, Rosario Ortiz, Nayeli Torres-Ramirez, Gerardo H. Vazquez-Nin
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2019)
Article
Toxicology
Zelmy Castro-Galvez, Monika Garrido-Armas, Margarita Isabel Palacios-Arreola, Ulises Torres-Flores, Guadalupe Rivera-Torruco, Ricardo Valle-Rios, Omar Amador-Munoz, Abrahan Hernandez-Hernandez, Francisco Arenas-Huertero
TOXICOLOGY IN VITRO
(2019)
Article
Oncology
Jesus Roberto Villalobos-Arellano, Diego Montesinos Valencia, Rosario Ortiz-Hernandez, Nayeli Torres-Ramirez, Olga Margarita Echeverria-Martinez, Abrahan Hernandez-Hernandez, Gerardo Hebert Vazquez-Nin
EXPERIMENTAL CELL RESEARCH
(2019)
Article
Cell Biology
Maria L. Escobar, Olga M. Echeverria, Sebastian Palacios-Martinez, Silvia Juarez-Chavero, Luis Sanchez-Sanchez, Gerardo H. Vazquez-Nin
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
(2019)
Article
Multidisciplinary Sciences
Erick Andres Mucino-Olmos, Aaron Vazquez-Jimenez, Ugo Avila-Ponce de Leon, Meztli Matadamas-Guzman, Vilma Maldonado, Tayde Lopez-Santaella, Abrahan Hernandez-Hernandez, Osbaldo Resendis-Antonio
SCIENTIFIC REPORTS
(2020)
Review
Genetics & Heredity
Ulises Torres-Flores, Abrahan Hernandez-Hernandez
FRONTIERS IN GENETICS
(2020)
Article
Oncology
Rosario Ortiz, Silvia Juarez Chavero, Olga M. Echeverria, Abrahan Hernandez-Hernandez
Summary: The study utilized an ultrastructural DNA staining technique on mouse testis to observe the organization of DNA in the SC. Bubble-like staining patterns were observed in certain regions, indicating that the specific organization of DNA is determined by chromosome synapsis, regardless of homology or partial SC formation.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Rosario Ortiz, Olga M. Echeverria, Sergej Masich, Christer Hoog, Abrahan Hernandez-Hernandez
Summary: This study analyzed the structure of the synaptonemal complex (SC) using cryo-fixation and electron microscopy. Compared to chemical fixation, cryo-fixation showed differences in the width of the central region of the SC and the density of the transverse filaments.
CHROMOSOME RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Abrahan Hernandez-Hernandez, Tayde Lopez-Santaella, Aranxa Torres-Caballero, Amarantha Serrato, Ulises Torres-Flores, Diego Montesinos-Valencia, Fernando Chico-Ponce De Leon, Vicente Gonzalez-Carranza, Samuel Torres-Garcia, Rosa Rebollar-Vega, Inti Alberto De la Rosa-Velazquez, Rosario Ortiz, Monserrat Perez-Ramirez, Normand Garcia-Hernandez, Antonio Garcia-Mendez, Francisco Arenas-Huertero
Summary: Central nervous system tumors are common in childhood and contribute to cancer-related mortality. This study explored the transcriptomic landscape of pediatric astrocytoma, focusing on the genetic alterations associated with tumorigenesis. The findings provide insights into the biological functions and pathways involved in astrocytoma, and establish a transcriptional signature for identifying different grades of the tumor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pediatrics
Aranxa Torres-Caballero, Amarantha Serrato, Tayde Lopez-Santaella, Rosario Ortiz, Fernando Chico-Ponce de Leon, Vicente Gonzalez-Carranza, Samuel Torres-Garcia, Francisco Arenas-Huertero, Abrahan Hernandez-Hernandez
BOLETIN MEDICO DEL HOSPITAL INFANTIL DE MEXICO
(2020)