Heat shock protein 90 inhibition by 17-DMAG lessens disease in the MRL/lpr mouse model of systemic lupus erythematosus

The benefit of targeted and selective inhibition of the alternative complement pathway for modulating autoimmunity and renal disease in MRL/lpr mice

(2011) Hideharu Sekine et al.   ARTHRITIS AND RHEUMATISM

Heat-shock protein 90 inhibition in autoimmunity to type VII collagen: evidence that nonmalignant plasma cells are not therapeutic targets

(2011) M. Kasperkiewicz et al.   BLOOD

Amelioration of systemic lupus erythematosus by withangulatin A in MRL/lpr mice

(2011) Lijuan Sun et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Histone Deacetylase 6 and Heat Shock Protein 90 Control the Functions of Foxp3+ T-Regulatory Cells

(2011) E. F. de Zoeten et al.   MOLECULAR AND CELLULAR BIOLOGY

Targeted tumor necrosis factor receptor I preligand assembly domain improves skin lesions in MRL/lpr mice

(2010) Guo-Min Deng et al.   ARTHRITIS AND RHEUMATISM

Suppression of autoimmunity and organ pathology in lupus-prone mice upon inhibition of calcium/calmodulin-dependent protein kinase type IV

(2010) Kunihiro Ichinose et al.   ARTHRITIS AND RHEUMATISM

17-DMAG targets the nuclear factor- B family of proteins to induce apoptosis in chronic lymphocytic leukemia: clinical implications of HSP90 inhibition

(2010) E. Hertlein et al.   BLOOD

17-Allylamino-17-demethoxygeldanamycin induces downregulation of critical Hsp90 protein clients and results in cell cycle arrest and apoptosis of human urinary bladder cancer cells

(2010) Panagiotis K Karkoulis et al.   BMC CANCER

Heat shock protein 90 inhibitors attenuate inflammatory responses in atherosclerosis

(2010) Julio Madrigal-Matute et al.   CARDIOVASCULAR RESEARCH

Increased Toll-Like Receptor (TLR) Activation and TLR Ligands in Recently Diagnosed Type 2 Diabetic Subjects

(2010) M. R. Dasu et al.   DIABETES CARE

Phase I Pharmacokinetic and Pharmacodynamic Study of 17-dimethylaminoethylamino-17-demethoxygeldanamycin, an Inhibitor of Heat-Shock Protein 90, in Patients With Advanced Solid Tumors

(2010) Ramesh K. Ramanathan et al.   JOURNAL OF CLINICAL ONCOLOGY

EC144, a Synthetic Inhibitor of Heat Shock Protein 90, Blocks Innate and Adaptive Immune Responses in Models of Inflammation and Autoimmunity

(2010) T. J. Yun et al.   JOURNAL OF IMMUNOLOGY

Dicer Insufficiency and MicroRNA-155 Overexpression in Lupus Regulatory T Cells: An Apparent Paradox in the Setting of an Inflammatory Milieu

(2010) A. A. Divekar et al.   JOURNAL OF IMMUNOLOGY

T cells as therapeutic targets in SLE

(2010) José C. Crispín et al.   Nature Reviews Rheumatology

B cells as therapeutic targets in SLE

(2010) Iñaki Sanz et al.   Nature Reviews Rheumatology

Identification of gp96 as a Novel Target for Treatment of Autoimmune Disease in Mice

(2010) Jung Min Han et al.   PLoS One

Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone

(2010) Bei Liu et al.   Nature Communications

Th17 and natural Treg cell population dynamics in systemic lupus erythematosus

(2009) Ji Yang et al.   ARTHRITIS AND RHEUMATISM

The atheroprotective properties of Hsp70: a role for Hsp70-endothelial interactions?

(2009) A. Graham Pockley et al.   CELL STRESS & CHAPERONES

Update on Hsp90 Inhibitors in Clinical Trial

(2009) Y. Kim et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

C3a receptor deficiency accelerates the onset of renal injury in the MRL/lpr mouse

(2009) Scott E. Wenderfer et al.   MOLECULAR IMMUNOLOGY

The AKT Axis as a Therapeutic Target in Autoimmune Diseases

(2009) Tianfu Wu et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

Experimental anti-GBM nephritis as an analytical tool for studying spontaneous lupus nephritis

(2008) Yong Du et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Small molecule inhibitors of Hsp90 potently affect inflammatory disease pathways and exhibit activity in models of rheumatoid arthritis

(2008) John W. Rice et al.   ARTHRITIS AND RHEUMATISM

Hsp70 and cardiac surgery: molecular chaperone and inflammatory regulator with compartmentalized effects

(2008) Petrus R. de Jong et al.   CELL STRESS & CHAPERONES

Novobiocin and Additional Inhibitors of the Hsp90 C-Terminal Nucleotide- binding Pocket

(2008) Alison Donnelly et al.   CURRENT MEDICINAL CHEMISTRY

Targeting Hsp90: small-molecule inhibitors and their clinical development

(2008) Tony Taldone et al.   CURRENT OPINION IN PHARMACOLOGY

Microarray Analysis of Glomerular Gene Expression in Murine Lupus Nephritis

(2008) Kae Teramoto et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES