Journal
CELLULAR & MOLECULAR IMMUNOLOGY
Volume 6, Issue 5, Pages 387-392Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/cmi.2009.50
Keywords
activin A; macrophage; maturation; CD68; CD14
Categories
Funding
- Natural Science Foundation of China [30671953, 30801005, 30901329]
- Ministry of Education of China [20070183013]
- Project of Science and Technology of Jilin Province [20080160]
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Activin A, a multifunctional factor of the transforming growth factor-beta (TGF-beta) superfamily, is mainly produced by microglia and macrophages, and its anti-inflammatory and pro-inflammatory activities are both related to macrophage functions. However the direct effect of activin A on the rest macrophages in vivo remains unclear. In the present study, the results showed that activin A not only increased NO and IL-1 beta release, but also promoted phagocytic abilities of mouse peritoneal macrophages in vitro and in vivo, whereas it did not influence MHC I and MHC II expression. Moreover, we found that activin A significantly upregulated the expressions of CD14 and CD68, markers of mature macrophages, on the surface of macrophages in vitro and in vivo. These data suggest that activin A can induce primary macrophage maturation in vitro and in vivo, but may not trigger the acquired immune response via regulating expression of MHC molecules involved in presentation of antigen. Cellular & Molecular Immunology. 2009;6(5):387-392.
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