Article
Cell & Tissue Engineering
M. C. M. Li, S. K-H. Chow, R. M. Y. Wong, B. Chen, J. C. Y. Cheng, L. Qin, W-H. Cheung
Summary: This study investigated the role of osteocyte-specific DMP1 in osteoporotic fracture healing augmented by low-magnitude high-frequency vibration (LMHFV). The results showed that blocking DMP1 would impair healing outcomes and negate the enhancement of fracture healing induced by LMHFV. These findings reveal the importance of DMP1 in response to mechanical signals during osteoporotic fracture healing.
BONE & JOINT RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Gustavo Ramos-Espinosa, Yuanyuan Wang, Johanna M. Brandner, Stefan W. Schneider, Christian Gorzelanny
Summary: CHI3L1 interacts with the extracellular matrix of melanoma cells, leading to increased secretion of cytokines and growth factors, promoting inflammatory response and angiogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Dentistry, Oral Surgery & Medicine
Cristiane Mayumi Inagati, Debora Lopes Salles Scheffel, Giovana Anovazzi, Juliana Rosa Luiz Alonso, Marcelly Tupan Christoffoli, David Henry Pashley, Carlos Alberto De Souza Costa, Josimeri Hebling
Summary: This study compared the proteolytic activity and degradation rate of human and bovine dentin matrices, finding differences in some aspects but no statistical difference after long-term incubation.
JOURNAL OF APPLIED ORAL SCIENCE
(2021)
Article
Engineering, Biomedical
F. Machla, V Sokolova, V Platania, O. Prymak, K. Kostka, B. Kruse, M. Agrymakis, S. Pasadaki, A. Kritis, K. Alpantaki, M. Vidaki, M. Chatzinikolaidou, M. Epple, A. Bakopoulou
Summary: Tissue engineering provides new treatment approaches for regenerating lost dental tissues, and this study investigated the characteristics of EDTA-treated, freeze-dried dentin matrices (HTFD scaffolds) conditioned with calcium phosphate nanoparticles (NPs) bearing dentinogenesis-inducing factors. The synthesized NPs showed efficient transfection of dental pulp stem cells (DPSCs), and HTFD/NPs constructs induced odontogenic shift of DPSCs, preserving cell viability and leading to the reconstruction of the ortho-dentin/odontoblastic layer barrier.
ACTA BIOMATERIALIA
(2023)
Article
Engineering, Biomedical
Yinghua Chen, Rahul Koshy, Elizabeth Guirado, Anne George
Summary: STIM1 plays an important role in dentin and alveolar bone mineralization by influencing intracellular Ca2+ oscillations. It regulates odontogenic differentiation and matrix mineralization by maintaining calcium homeostasis and initiating store-operated Ca2+ entry. Inhibition of STIM1 impairs signaling, exosome release, and mineralization in dentin matrix formation.
ACTA BIOMATERIALIA
(2021)
Article
Endocrinology & Metabolism
Christoph Klenk, Leif Hommers, Martin J. Lohse
Summary: This study reveals that the extracellular domain of PTH1R is cleaved by metalloproteinases, leading to impaired stability of the receptor. The cleavage site is located in the first loop of the extracellular domain. A receptor mutant resistant to proteolytic cleavage showed reduced signaling to G(s) and increased activation of G(q).
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sampath Kumar Katakam, Valeria Tria, Wey-Cheng Sim, George W. Yip, Stefano Molgora, Theodoros Karnavas, Eslam A. Elghonaimy, Paride Pelucchi, Eleonora Piscitelli, Sherif Abdelaziz Ibrahim, Ileana Zucchi, Rolland Reinbold, Burkhard Greve, Martin Goette
Summary: The downregulation of Sdc-1 in colon cancer is associated with increased invasiveness, metastasis, and potential tumor-initiating cell phenotype. Sdc-1 depletion enhances cancer stem cell properties and resistance to chemotherapy, while also promoting invasive growth of cancer cells.
Article
Dentistry, Oral Surgery & Medicine
Jeeranan Manokawinchoke, Suconta Chareonvit, Vorapat Trachoo, Phoonsuk Limraksasin, Hiroshi Egusa, Thanaphum Osathanon
Summary: This study investigated the effect of intermittent compressive force (ICF) on the expression of dentin matrix protein-1 (DMP1) in human periodontal ligament stem cells (hPDLSCs). It was found that ICF could induce DMP1 expression through the regulation of the TGF-b signaling pathway.
JOURNAL OF DENTAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Zhourui Wu, Yiyuan Xia, Zhihao Wang, Seong Su Kang, Kecheng Lei, Xia Liu, Lingjing Jin, Xiaochuan Wang, Liming Cheng, Keqiang Ye
Summary: The study reveals that C/EBP beta acts as an age-dependent transcription factor for alpha-Syn and MAOB, initiating Parkinson's disease pathologies. It shows that by altering the expression levels of C/EBP beta, the pathologies related to alpha-Syn and MAOB can be affected.
MOLECULAR PSYCHIATRY
(2021)
Review
Biochemistry & Molecular Biology
John R. Couchman
Summary: Cell surface proteoglycans, such as syndecans, play crucial roles in regulating cell behavior, including interactions with extracellular matrix components and mediating proliferation, adhesion, and migration. In tumors, changes in the levels and distribution of syndecan-1 can have implications for prognosis, with loss of membrane staining and abnormal cytoplasmic or nuclear staining often indicating poor outcomes. Targeting syndecan-1 with antibody-toxin conjugates may hold promise for clinical applications in both myeloma and some carcinomas.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Dentistry, Oral Surgery & Medicine
Zhenwei Zhang, Guibin Huang, Yu Huang, Siyi Liu, Feng Chen, Xuejun Gao, Yanmei Dong, Hua Tian
Summary: This study aimed to identify candidate genes for inheritable dentin defects in three Chinese pedigrees and characterize the property of affected teeth. Clinical and radiological features were recorded for the affected individuals. Genomic analysis identified three novel frameshift mutations of dentin sialophosphoprotein gene related to inherited dentin defects.
ARCHIVES OF ORAL BIOLOGY
(2023)
Article
Dermatology
Mengjun Xu, Jiong Zhou, Jianliang Yan, Jianyou Wang
Summary: Lipoid proteinosis (LP) is a rare autosomal recessive disorder caused by mutations in the ECM1 gene. Two Chinese siblings with LP-like symptoms were found to have one known and one novel pathogenic variant in ECM1 gene, inherited from their unaffected parents. The novel mutation caused mRNA decay and loss of function. This finding adds to the understanding of the genetic etiology of LP.
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
(2023)
Article
Engineering, Biomedical
Evan Hoffman, Yuefan Song, Fuming Zhang, Loredana Asarian, Isaac Downs, Brad Young, Xiaorui Han, Yilan Ouyang, Ke Xia, Robert J. Linhardt, Daniel J. Weiss
Summary: Decellularized lung scaffolds and hydrogels are widely used in ex vivo lung bioengineering. Differences in glycosaminoglycan (GAG) composition and function were observed between normal, COPD, and IPF lungs in different regions. These findings provide important insights into the role of ECM GAGs in lung function and disease.
ACTA BIOMATERIALIA
(2023)
Article
Chemistry, Multidisciplinary
Lucia Meme, Enrico M. Strappa, Riccardo Monterubbianesi, Fabrizio Bambini, Stefano Mummolo
Summary: This study investigated the effect of different demineralization times on the chemical composition and surface morphology of dentin particles. The results demonstrated that increasing demineralization time led to a smoother surface and a higher number of dentinal tubules.
APPLIED SCIENCES-BASEL
(2022)
Letter
Plant Sciences
Paula Vacs, Rodolfo Rasia, Nahuel Gonzalez-Schain
Summary: During seedling germination, HYPONASTIC LEAVES 1 regulates apical hook development by modulating the formation of an auxin gradient.
Article
Cell Biology
Chao Liu, Hua Zhang, Priyam Jani, Xiaofang Wang, Yongbo Lu, Nan Li, Jing Xiao, Chunlin Qin
JOURNAL OF CELLULAR PHYSIOLOGY
(2018)
Article
Developmental Biology
Josephine L. Morris, Stephen J. Cross, Yinhui Lu, Karl E. Kadler, Yongbo Lu, Sarah L. Dallas, Paul Martin
DEVELOPMENTAL BIOLOGY
(2018)
Article
Oncology
Chao Liu, Nan Zhou, Yu Wang, Hua Zhang, Priyam Jani, Xiaofang Wang, Yongbo Lu, Nan Li, Jing Xiao, Chunlin Qin
EXPERIMENTAL CELL RESEARCH
(2018)
Article
Endocrinology & Metabolism
Yongbo Lu, Suzan A. Kamel-El Sayed, Kun Wang, LeAnn M. Tiede-Lewis, Michael A. Grillo, Patricia A. Veno, Vladimir Dusevich, Charlotte L. Phillips, Lynda F. Bonewald, Sarah L. Dallas
JOURNAL OF BONE AND MINERAL RESEARCH
(2018)
Article
Multidisciplinary Sciences
Hua Zhang, Xiaohua Xie, Peihong Liu, Tian Liang, Yongbo Lu, Chunlin Qin
Article
Dentistry, Oral Surgery & Medicine
Xuenan Liu, Nan Li, Hua Zhang, Jing Liu, Nan Zhou, Chunxiao Ran, Xiaoyan Chen, Yongbo Lu, Xiaofang Wang, Chunlin Qin, Jing Xiao, Chao Liu
EUROPEAN JOURNAL OF ORAL SCIENCES
(2018)
Article
Dentistry, Oral Surgery & Medicine
T. Liang, H. Zhang, Q. Xu, S. Wang, C. Qin, Y. Lu
JOURNAL OF DENTAL RESEARCH
(2019)
Article
Cell Biology
Lora A. Shiflett, Leann M. Tiede-Lewis, Yixia Xie, Yongbo Lu, Eleanor C. Ray, Sarah L. Dallas
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2019)
Article
Cell Biology
Lili Li, Wuliji Saiyin, Hua Zhang, Suzhen Wang, Qian Xu, Chunlin Qin, Yongbo Lu
JOURNAL OF MOLECULAR HISTOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Wuliji Saiyin, Lili Li, Hua Zhang, Yongbo Lu, Chunlin Qin
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2019)
Review
Dentistry, Oral Surgery & Medicine
J. D. Oliver, E. C. Turner, L. R. Halpern, S. Jia, P. Schneider, R. N. D'Souza
JOURNAL OF DENTAL RESEARCH
(2020)
Article
Dentistry, Oral Surgery & Medicine
Hua Zhang, Qian Xu, Yongbo Lu, Chunlin Qin
Summary: This study demonstrates that a high phosphate diet improves dentin volume fraction and mineral density in Fam20c-deficient mice, preventing pulp infection and dental abscesses. These results suggest that hypophosphatemia is a significant contributor to dentin defects in Fam20c-deficient subjects.
EUROPEAN JOURNAL OF ORAL SCIENCES
(2021)
Article
Developmental Biology
Qian Xu, Hua Zhang, Suzhen Wang, Chunlin Qin, Yongbo Lu
Summary: XBP1S is a crucial mediator in the IRE1 branch for alleviating ER stress. Precise control of XBP1S production is essential for normal mouse development as demonstrated in experiments.
Editorial Material
Dentistry, Oral Surgery & Medicine
Judith Albino, Bruce A. Dye, Rena N. D'Souza
JOURNAL OF DENTAL EDUCATION
(2022)
Article
Developmental Biology
Shihai Jia, Jing Zhou, Christopher Fanelli, Yinshen Wee, John Bonds, Pascal Schneider, Gabriele Mues, Rena N. D'Souza