Article
Biochemistry & Molecular Biology
Xavier Capo, Margalida Monserrat-Mesquida, Magdalena Quetglas-Llabres, Juan M. Batle, Josep A. Tur, Antoni Pons, Antoni Sureda, Silvia Tejada
Summary: Hyperbaric oxygen therapy (HBOT) is clinically used to apply oxygen at pressures higher than atmospheric pressure. This study aimed to analyze the effects of HBOT on plasma oxidative and inflammation biomarkers and growth factors in patients with chronic diabetic wounds. The results showed that HBOT reduced oxidative and pro-inflammatory mediators, and increased the release of growth factors, potentially playing a role in wound healing, angiogenesis, and vascular tone regulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dermatology
Jianghe Zhang, Yan Yan, Yujie Li, Chengcheng Shen, Yiming Zhang
Summary: Benzalkonium bromide (BB) showed the best wound infection control efficiency while delaying wound healing, and exhibiting higher cytotoxicity and inducing more cell apoptosis compared to other antiseptics like PVP-I and CHG. BB also induced more cell apoptosis and ROS production at higher levels, possibly leading to delayed wound healing.
INTERNATIONAL WOUND JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Yun-Lung Chung, Pei-Yu Chou, Ming-Jyh Sheu
Summary: This study evaluated the wound-healing activity of PEDOT: PSS and found that it significantly improved wound healing in SD rats. The treatment increased angiogenic behavior and VEGF expression, indicating its angiogenic effects. The results suggest that PEDOT: PSS can be potentially used as a dressing for medical use.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Xiao Feng, Wei Feng, Yu Ji, Tingting Jin, Jingyu Li, Jincai Guo
Summary: This study investigates the relationship between TGF-beta 1 and SOCS7 in the re-epithelialization of keratinocytes during skin wound healing. The results show that TGF-beta 1 downregulates SOCS7 expression and overexpression of SOCS7 suppresses TGF-beta 1-induced keratinocyte migration. TGF-beta 1 negatively regulates SOCS7 through the binding of EGR1 to the SOCS7 promoter. This study identifies the TGF-beta 1/EGR1/SOCS7 pathway as a potential therapeutic target for promoting wound healing.
CELL COMMUNICATION AND SIGNALING
(2022)
Review
Biochemistry & Molecular Biology
Laura Accipe, Alisson Abadie, Remi Neviere, Sylvie Bercion
Summary: Diabetic wound healing is a global challenge, mainly caused by excessive production of ROS and impaired detoxification in diabetes, leading to destruction of extracellular matrix and inflammation. Medicinal plants and natural compounds can improve healing by targeting oxidative stress and inflammation pathways. This study highlights the role of polyphenolic compounds in diabetic wound healing.
Article
Immunology
Yao Zhang, Hidetaka Ideguchi, Hiroaki Aoyagi, Keisuke Yamashiro, Tadashi Yamamoto, Masahiro Nishibori, Shogo Takashiba
Summary: Malnutrition leads to delayed wound healing by potentially interfering with the HMGB1-IL-1 beta inflammatory response cascade. This study observed changes in related factors in a malnutrition mouse model and identified the mechanism of delayed wound healing.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiao-Hui Wang, Wei Guo, Wei Qiu, Luo-Quan Ao, Meng-Wei Yao, Wei Xing, Yang Yu, Quan Chen, Xiao-Feng Wu, Zhan Li, Xue-Ting Hu, Xiang Xu
Summary: This study reveals a novel function of PD-L1 in wound healing, showing that PD-L1 acts as a positive regulator by forming an immunosuppressive microenvironment, modulating macrophage polarization and promoting inflammation resolution. Loss of PD-L1 delays wound healing, especially in the presence of severe inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Immunology
Samuel Knoedler, Sonja Broichhausen, Ruiji Guo, Ruoxuan Dai, Leonard Knoedler, Martin Kauke-Navarro, Fortunay Diatta, Bohdan Pomahac, Hans-Guenther Machens, Dongsheng Jiang, Yuval Rinkevich
Summary: Injuries to the skin initiate a series of synchronized healing processes. Fibroblasts play various roles in endogenous wound repair, including activating innate immune cells, depositing scar tissue, and transporting fascial connective tissue to the wounds. Understanding the diversity and versatility of fibroblasts is crucial for deciphering wound pathologies and developing new treatment approaches.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Physiology
Jiri Ruzicka, Jiri Dejmek, Lukas Bolek, Jiri Benes, Jitka Kuncova
Summary: Hyperbaric oxygen therapy (HBOT) may have a positive effect on the healing of chronic wounds by increasing the production of reactive oxygen and nitrogen radicals, elevating the concentration of Hypoxia inducible factor (HIF) 1, and supporting the synthesis of growth factors. HBOT also has antimicrobial effects, enhances the effectiveness of antibiotics, stimulates fibroblast growth and collagen synthesis, while suppressing the activity of proteolytic enzymes like matrix metalloproteinases.
PHYSIOLOGICAL RESEARCH
(2021)
Article
Nanoscience & Nanotechnology
Abdulrahman E. Koshak, Mardi M. Algandaby, Mohammad Mujallid, Ashraf B. Abdel-Naim, Nabil A. Alhakamy, Usama A. Fahmy, Anas Alfarsi, Shaimaa M. Badr-Eldin, Thikryat Neamatallah, Mohammed Z. Nasrullah, Hossam M. Abdallah, Ahmed Esmat
Summary: OFI and OFI-SNEDDS demonstrated superior wound healing activity in a rat model of full-thickness skin excision, with enhanced antioxidant and anti-inflammatory properties. OFI-SNEDDS showed higher activity compared to OFI seed oil, improving collagen and angiogenesis expression.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Judith C. J. Holzer-Geissler, Simon Schwingenschuh, Martin Zacharias, Johanna Einsiedler, Sonja Kainz, Peter Reisenegger, Christian Holecek, Elisabeth Hofmann, Barbara Wolff-Winiski, Hermann Fahrngruber, Thomas Birngruber, Lars-Peter Kamolz, Petra Kotzbeck
Summary: The treatment of chronic wounds poses a challenge for modern medicine due to the complex pathophysiology involved. Previous wound models used for studying chronic wounds lack translatability to patients and often overlook the impact of exaggerated inflammation. This study aims to investigate the role of prolonged inflammation in a porcine wound model using the TLR7 and TLR8 agonist resiquimod. The results demonstrate that prolonged inflammation delays wound healing, a common observation in chronic wounds. This model highlights the importance of inflammation in wound healing and provides insights into the progression of chronic wounds.
Article
Pharmacology & Pharmacy
Basma G. Eid, Nabil A. Alhakamy, Usama A. Fahmy, Osama A. A. Ahmed, Shadab Md, Ashraf B. Abdel-Naim, Giuseppe Caruso, Filippo Caraci
Summary: The study aimed to evaluate the synergistic effect of melittin and diclofenac in a nano-complex, which showed significantly better wound healing activity compared to individual drugs. The nano-complex promoted regenerated epithelium and granulation tissue formation, as well as exhibited enhanced antioxidant activity.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Medicine, General & Internal
Dharshan Sivaraj, Chikage Noishiki, Nina Kosaric, Harriet Kiwanuka, Hudson C. Kussie, Dominic Henn, Katharina S. Fischer, Artem A. Trotsyuk, Autumn H. Greco, Britta A. Kuehlmann, Filiberto Quintero, Melissa C. Leeolou, Maia B. Granoski, Andrew C. Hostler, William W. Hahn, Michael Januszyk, Ferid Murad, Kellen Chen, Geoffrey C. Gurtner
Summary: According to the American Diabetes Association, there is a significant unmet need for new therapies to accelerate the closure of non-healing wounds. In this study, the effects of NO-releasing gel on diabetic wound healing in mice were investigated. The results showed that topical administration of NO-gel significantly accelerated the rate of wound healing and promoted a more regenerative ECM architecture.
FRONTIERS IN MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Zhiguo Li, Xiaotong Fan, Zheng Luo, Xian Jun Loh, Yedong Ma, Enyi Ye, Yun-Long Wu, Chaobin He, Zibiao Li
Summary: The authors developed a multifunctional nanoenzyme-chitosan hydrogel complex to improve the microenvironment of diabetic wounds and provide continuous oxygen delivery. By reducing glucose and reactive oxygen species concentrations and promoting cell proliferation, migration, and angiogenesis, the complex significantly accelerated diabetic wound healing.
Article
Biochemistry & Molecular Biology
Tarfah Al-Warhi, Eman Maher Zahran, Samy Selim, Mohammad M. Al-Sanea, Mohammed M. Ghoneim, Sherif A. Maher, Yaser A. Mostafa, Faisal Alsenani, Mahmoud A. Elrehany, Mohammed S. Almuhayawi, Soad K. Al Jaouni, Usama Ramadan Abdelmohsen, Abeer H. Elmaidomy
Summary: This study demonstrates the potential of Vitis vinifera seed extract in promoting wound healing by accelerating wound closure rates, increasing TGF-beta and VEGF levels, and reducing TNF-alpha and IL-1 beta levels. Phytochemical analysis identified multiple compounds, and molecular docking experiments were performed to investigate the mechanisms of action.