Review
Immunology
Yousif Saleh Ibrahim, Ali H. Amin, Zanko Hassan Jawhar, Mohammad A. Alghamdi, Ghaidaa Raheem Lateef Al-Awsi, Abdullah M. Shbeer, Hasan S. AL-Ghamdi, Gamal A. Gabr, Andres Alexis Ramirez-Coronel, Abbas F. Almulla
Summary: Despite progress in treating different malignancies, melanoma remains a lethal skin tumor type. Early diagnosis and surgery provide high survival rates, but advanced metastatic stages greatly decrease survival rates. Immunotherapeutics have shown promise in promoting tumor-specific immune responses, but adverse effects of Treg cells hinder clinical outcomes.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Geosciences, Multidisciplinary
R. Damian Nance, David A. D. Evans, J. Brendan Murphy
Summary: The existence of the putative Ediacaran supercontinent Pannotia has been questioned and the interpretation of related data is controversial, but it plays a crucial role in the evolution of supercontinent cycles.
EARTH-SCIENCE REVIEWS
(2022)
Review
Medicine, Research & Experimental
Ling Xu, Yu 'e Liu, Xi Chen, Hua Zhong, Yi Wang
Summary: Ferroptosis is a novel type of programmed cell death characterized by dysregulated iron metabolism and accumulation of lipid peroxides. It plays a critical role in cancers and other diseases, inhibiting the proliferation of malignant cells and offering potential as a new method of cancer treatment. Inhibitors targeting key factors of ferroptosis have been developed and the application of ferroptosis is focused on avoiding it in healthy cells and selectively inducing it in cancers.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Communication
Anne-Britt Gran, Peter Booth, Taina Bucher
Summary: Algorithms are increasingly important in internet infrastructure, impacting decisions from music recommendations to policing, healthcare, and social benefits. Awareness of algorithms could create a new digital divide. A study in Norway found demographic differences in algorithm awareness and attitudes, leading to a typology of algorithm awareness groups: unaware, uncertain, affirmative, neutral, skeptical, and critical.
INFORMATION COMMUNICATION & SOCIETY
(2021)
Editorial Material
Medicine, General & Internal
Marianna Evangelia Kapsetaki
Summary: This passage discusses the advantages, disadvantages, opportunities, and challenges of pursuing excellence in one or multiple fields, drawing from the author's own experience as a medical doctor, classical pianist, and neuroscientist, as well as from the examples of polymaths in history.
POSTGRADUATE MEDICAL JOURNAL
(2023)
Editorial Material
Immunology
Emelie Barreby, Myriam Aouadi
Summary: This article primarily introduces the strategies for localizing liver macrophage populations and their communication with neighboring cells, which is of great significance for better understanding the diversity and functions of liver macrophages.
Review
Biochemistry & Molecular Biology
Ewa Gurgul-Convey
Summary: S1P plays an important role in pancreatic insulin-secreting beta-cells and is associated with the development of diabetes. The inflammatory component of diabetes remains under-characterized, but environmental factors such as a westernized diet may participate in the enhanced inflammatory response. Disturbed lipid metabolism and polymorphisms in genes encoding S1P-generating enzymes are found to be associated with diabetes development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Astronomy & Astrophysics
Randa Asa'd, V. D. Ivanov, I. Negueruela, J. M. John, A. Gonneau, M. Rejkuba
Summary: Recent surveys have found new young massive clusters near the inner Galaxy, containing dozens of red supergiants. However, many of these clusters have not been fully studied. Using infrared spectra, a radial velocity analysis was conducted on the putative members of the candidate RSG cluster Alicante-8. The results showed a large dispersion of radial velocities among the candidate stars, suggesting that Alicante-8 is not a real cluster. The misclassification of Alicante-8 as a candidate RSG cluster was due to incorrect assumption about the candidate stars being RSGs.
ASTRONOMICAL JOURNAL
(2023)
Review
Cell Biology
Rut Fado, Sebastian Zagmutt, Laura Herrero, Helena Muley, Rosalia Rodriguez-Rodriguez, Huichang Bi, Dolors Serra, Nuria Casals
Summary: There is a need for reliable genetic biomarkers in the diagnosis, prognosis, and treatment of different tumor types. One potential biomarker is CPT1C, a neuronal protein involved in cancer cell adaptation to nutrient depletion and hypoxia. However, its molecular role in cancer cells is controversial. This review discusses the evidence on CPT1C in neurons and its potential role in lipid metabolism and cell adaptation to stressors in cancer cells.
CELL DEATH & DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Skye Montoya, Deborah Soong, Nina Nguyen, Maurizio Affer, Sailasya P. Munamarty, Justin Taylor
Summary: Development of targeted therapies has provided nonchemotherapeutic options for patients, with small molecule kinase inhibitors being a key focus. However, resistance to these therapies may develop, necessitating multiple lines of treatment. Combinations of therapies targeting complimentary pathways may be more effective in overcoming drug resistance.
Article
Information Science & Library Science
Zhiqin Lu, Peng Li, Qinghai Li, Heng Zhang
Summary: This paper systematically discusses the impact of the digital divide on individual happiness in China, taking into account the variations across different groups and the corresponding mechanisms. It is the first study to examine the impact and variations of the three-level digital divide on individual happiness.
INFORMATION TECHNOLOGY & PEOPLE
(2023)
Review
Oncology
Rebecca C. Abbott, Hannah E. Hughes-Parry, Misty R. Jenkins
Summary: Genetically engineered T cells have been effective in treating hematological malignancies, but not in solid tumors. Biological logic gating in T cells is a promising approach to overcome the challenges associated with solid tumors.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Medicine, Research & Experimental
Qiong Zhou, Chunyu Tao, Jiakai Yuan, Fan Pan, Rui Wang
Summary: Ferroptosis, a programmed cell death form discovered in 2012, is characterized by imbalances in iron metabolism, lipid metabolism, and antioxidant metabolism. CD8 + T cells can trigger ferroptosis in tumor cells by releasing interferon-γ. This review examines the potential biological significance of the ferroptosis phenotype and reviews the latest advancements in understanding the mechanism of ferroptosis-mediated anti-tumor immunotherapy.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Zi-Jun Yan, Lei Chen, Hong-Yang Wang
Summary: Given the liver's regenerative capacity, researchers have focused on liver progenitor cells (LPCs) and liver cancer stem cells (LCSCs). LPCs can differentiate into hepatocytes and cholangiocytes, but the mechanisms underlying cell conversion and their roles in liver homeostasis and tumorigenesis are unclear. This review discusses the complex conversions involving LPCs and LCSCs, emphasizing their dual roles in liver regeneration and tumor formation. Understanding the sources and transformations of LPCs is crucial for harnessing their regenerative potential in the future.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Article
Chemistry, Multidisciplinary
Rafael Islas, David Arias-Olivares, Andres Becerra-Buitrago, Luis Carlos Garcia-Sanchez, Lya Neftaly Mendez-Ayon, Bernardo Zuniga-Gutierrez
Summary: In this study, the electronic delocalization of metallacycles based on borazine was analyzed using magnetic and electronic criteria. The results showed that metal-N bonded borazines can be classified as delocalized compounds, while metal-B bonded borazines can be classified as nonaromatic or weak aromatic compounds.
Article
Cell Biology
Ce Liu, XingWang Zhao, LiLing Xu, JunYang Yi, Samina Shaheen, Weidong Han, Fei Wang, Wenjie Zheng, Chenqi Xu, Wanli Liu
JOURNAL OF LEUKOCYTE BIOLOGY
(2015)
Article
Immunology
Liling Xu, Mengdie Xia, Jun Guo, Xiaolin Sun, Hua Li, Chenguang Xu, Xiaomei Gu, Haowen Zhang, Junyang Yi, Yan Fang, Hengyi Xie, Jing Wang, Zhixun Shen, Boxin Xue, Yujie Sun, Tobias Meckel, Ying-Hua Chen, Zhibin Hu, Zhanguo Li, Chenqi Xu, Haipeng Gong, Wanli Liu
JOURNAL OF EXPERIMENTAL MEDICINE
(2016)
Article
Multidisciplinary Sciences
Wei Yang, Yibing Bai, Ying Xiong, Jin Zhang, Shuokai Chen, Xiaojun Zheng, Xiangbo Meng, Lunyi Li, Jing Wang, Chenguang Xu, Chengsong Yan, Lijuan Wang, Catharine C. Y. Chang, Ta-Yuan Chang, Ti Zhang, Penghui Zhou, Bao-Liang Song, Wanli Liu, Shao-Cong Sun, Xiaolong Liu, Bo-liang Li, Chenqi Xu
Review
Immunology
Wanli Liu, Haopeng Wang, Chenqi Xu
TRENDS IN IMMUNOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Wei Yang, Weiling Pan, Shuokai Chen, Nicola Trendel, Shutan Jiang, Feng Xiao, Manman Xue, Wei Wu, Zeli Peng, Xiaoxi Li, Hongbin Ji, Xiaolong Liu, Hai Jiang, Haopeng Wang, Hongbin Shen, Omer Dushek, Hua Li, Chenqi Xu
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2017)
Article
Multidisciplinary Sciences
Lunyi Li, Xingdong Guo, Xiaoshan Shi, Changting Li, Wei Wu, Chengsong Yan, Haopeng Wang, Hua Li, Chenqi Xu
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Biochemistry & Molecular Biology
Wei Yang, Weiling Pan, Shuokai Chen, Nicola Trendel, Shutan Jiang, Feng Xiao, Manman Xue, Wei Wu, Zeli Peng, Xiaoxi Li, Hongbin Ji, Xiaolong Liu, Hai Jiang, Haopeng Wang, Hongbin Shen, Omer Dushek, Hua Li, Chenqi Xu
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2017)
Review
Cell Biology
Xing He, Chenqi Xu
Editorial Material
Cell Biology
Chenqi Xu, Hua-Bing Li, Richard A. Flavell
Review
Immunology
Haopeng Wang, Yuwei Huang, Chenqi Xu
Summary: Chimeric antigen receptor (CAR)-T cell therapy is a promising approach for cancer treatment, but the current CAR design is not as robust as the natural antigen receptor TCR. Understanding how electrostatic charge regulates TCR/CAR signaling events will facilitate the development of next-generation T cell therapies.
IMMUNOLOGICAL REVIEWS
(2023)
Review
Oncology
Haopeng Wang, Xianming Song, Lianjun Shen, Xinxin Wang, Chenqi Xu
Summary: Engineered T cell therapies, such as CAR-T and TCR-T, are at the forefront of cancer treatment. CAR-T and TCR-T differ in their characteristics, including cell persistence and toxicity, which result in different therapeutic outcomes. Understanding the molecular structures and signaling properties of TCR and CAR can pave the way for the development of next generation T cell therapies.
Review
Endocrinology & Metabolism
Binlu Huang, Bao-Liang Song, Chenqi Xu
Article
Immunology
Chenguang Xu, Hengyi Xie, Xingdong Guo, Haipeng Gong, Lei Liu, Hai Qi, Chenqi Xu, Wanli Liu
SCIENCE IMMUNOLOGY
(2017)
Article
Cell Biology
Xingdong Guo, Chengsong Yan, Hua Li, Wenmao Huang, Xiaoshan Shi, Min Huang, Yingfang Wang, Weiling Pan, Mingjun Cai, Lunyi Li, Wei Wu, Yibing Bai, Chi Zhang, Zhijun Liu, Xinyan Wang, Xiaohui F. Zhang, Chun Tang, Hongda Wang, Wanli Liu, Bo Ouyang, Catherine C. Wong, Yi Cao, Chenqi Xu
Review
Immunology
Wei Wu, Xiaoshan Shi, Chenqi Xu
NATURE REVIEWS IMMUNOLOGY
(2016)
