Article
Materials Science, Biomaterials
Yijie Wang, Hui Zhang, Shiyang Wu, Wanting Wan, Xueping Kang, Bei Gao, Haoyu Shi, Shuyang Zhao, Lin Niu, Rui Zou
Summary: This study investigated the mechanism of proliferation and apoptosis of periodontal ligament cells (PDLCs) through an in vitro model. It was found that the proliferation and apoptosis of PDLCs are dependent on substrate stiffness, with stiffer substrates promoting increased proliferation. Depletion of integrin-linked kinase (ILK) diluted the correlation between PDLC behaviors and substrate stiffness. These findings suggest that ILK plays a significant role in modulating PDLC proliferation and apoptosis and can be a potential target for accelerating orthodontic tooth movement (OTM).
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Dentistry, Oral Surgery & Medicine
Sinan Mert, Hanna Malyaran, Rogerio B. Craveiro, Michael Wolf, Ali Modabber, Willi Jahnen-Dechent, Sabine Neuss
Summary: Clinical experience suggests that wounds in the maxilla heal faster and more efficiently compared with the mandible. This study aimed to investigate whether differences in the proliferation and differentiation of periodontal ligament stem cells (PDLSC) from the maxilla and mandible contribute to this discrepancy. The results showed that maxillary PDLSC exhibited higher proliferation and differentiation potential compared to mandibular PDLSC, indicating a possible cell-based explanation for the different healing efficacy in the maxilla and mandible.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Genetics & Heredity
Xuechun Zhao, Zhigang Xie, Nanquan Rao, Shu Zhang, Yunpeng Zhang
Summary: Human periodontal ligament stem cells (hPDLSCs) are potential seed cells for oral bone tissue engineering. Dermatopontin (DPT) has been found to be elevated during the osteogenic differentiation of hPDLSCs. Interfering with DPT expression inhibited the proliferation and osteogenic differentiation ability of hPDLSCs, while exogenous DPT treatment only enhanced the osteogenic differentiation of hPDLSCs in the control group. This study suggests that DPT is an important target for enhancing the osteogenic differentiation of hPDLSCs.
Review
Pharmacology & Pharmacy
Edward J. Calabrese
Summary: This paper provides a detailed assessment of hormetic dose responses by human periodontal ligament stem cells, induced by a broad range of chemicals. The underlying mechanistic foundations of these dose responses are clarified, showing them to be widespread and highly conserved across different types of stem cells. The therapeutic implications of these hormetic dose responses are explored, highlighting their potential in various applications.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Engineering, Biomedical
Leila Gholami, Seyedeh Sareh Hendi, Massoud Saidijam, Roghayeh Mahmoudi, Rana Tarzemany, Aliasghar Arkian, Saeid Afshar, Reza Fekrazad
Summary: The study evaluated the effect of near-infrared PBM on inflamed periodontal ligament stem cells, showing that PBM did not significantly increase cell proliferation but significantly increased the expression of osteogenic-related genes and alkaline phosphatase activity.
LASERS IN MEDICAL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Leila Gholami, Gilda Parsamanesh, Shiva Shahabi, Marzieh Jazaeri, Kaveh Baghaei, Reza Fekrazad
Summary: The study found that near-infrared low-intensity laser PBM has positive effects on the proliferation, viability, and osteogenic differentiation of stem cells isolated from human periodontal ligament, leading to improved mineralized tissue deposition and increased expression of VEGF and BMP.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2021)
Article
Medicine, Research & Experimental
Min Yi, Guanglei Wang, Jianhua Niu, Minghui Peng, Yi Liu
Summary: The present study found that PTE can promote the proliferation and differentiation of hPDLSCs, alleviate inflammation and cell apoptosis. PTE also inhibits the expression of HDACs, which may be involved in the mechanism of periodontitis.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Oliwia Milek, Dino Tur, Lucia Ahcin, Olha Voitseshyna, Christian Behm, Oleh Andrukhov
Summary: This study investigated the impact of osteogenic differentiation on the immunomodulatory properties of hPDL-MSCs, and found that osteogenic differentiation reduced the ability of hPDL-MSCs to suppress CD4(+) T lymphocyte proliferation and enhanced this ability in the presence of IL-1 beta. Additionally, the expression and activity of indoleamine-2,3-dioxygenase and interleukin-8 were also affected by the differentiation process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Orie Adachi, Hideki Sugii, Tomohiro Itoyama, Shoko Fujino, Hiroshi Kaneko, Atsushi Tomokiyo, Sayuri Hamano, Daigaku Hasegawa, Junko Obata, Shinichiro Yoshida, Masataka Kadowaki, Risa Sugiura, Mhd Safwan Albougha, Hidefumi Maeda
Summary: The study aims to clarify the biological functions of decorin in the healing and regeneration of wounded periodontal tissue. The results demonstrate that decorin promotes osteoblastic differentiation of periodontal ligament stem cells and contributes to bone healing through ERK1/2 signaling pathway.
Article
Multidisciplinary Sciences
Luminita Labusca, Camelia Danceanu, Anca Emanuela Minuti, Dumitru-Daniel Herea, Adrian Ghemes, Cristian Rotarescu, Oana Dragos-Pinzaru, Mihai Tibu, Grigoras Marian, Horia Chiriac, Nicoleta Lupu
Summary: Magnetic nanomaterials have a growing impact in the field of biology and medicine due to their versatility in drug delivery, cell targeting, and imaging. This study investigates the use of uncoated nickel nanowires as a mechanically-responsive substrate for inducing osteogenic differentiation of adipose derived-mesenchymal cells (ASCs) through magneto-mechanical stimulation. Preliminary results show a significant increase in osteogenic differentiation of ASCs exposed to a specific magnetic field, while adipogenic differentiation remains unchanged.
SCIENTIFIC REPORTS
(2022)
Article
Biology
Vahid Esfahanian, Fatemeh Ejeian, Hajar Mohebinia, Zahra Sadat Zojaji Nejad, Maryam Yazdchi, Maziar Ebrahimi Dastgerdi, Mehrnoush Ebrahimi Dastgerdi, Mohammad Hossein Nasr-Esfahani
Summary: Periodontal regeneration through bone substitutes has shown promising results in both animal and clinical studies. This study compared the behavior of periodontal ligament stem cells in the presence of different bone grafting substitutes. The results showed that xenografts exhibited the highest cellular attachment and proliferation rate, while alloplasts had the lowest proliferation capacity and osteogenesis.
Article
Engineering, Biomedical
Hong Cao, Qian Zhou, Chungeng Liu, Yecen Zhang, Minghui Xie, Weihua Qiao, Nianguo Dong
Summary: This study investigates the effect of substrate stiffness on the differentiation of human-induced pluripotent stem cells (h-iPSCs) into valve endothelial-like cells (h-iVECs). The results show that moderate substrate stiffness can enhance the differentiation efficiency of h-iVECs and is regulated by the WNT/Calcineurin signaling pathway. This study emphasizes the importance of using substrate stiffness to achieve a more specific and mature differentiation of h-iVECs.
ACTA BIOMATERIALIA
(2022)
Article
Dentistry, Oral Surgery & Medicine
Ming Ying, Bin Zhang
Summary: This study investigated the effect of daidzein on the proliferation and osteogenic differentiation of human periodontal ligament stem cells. It was found that daidzein promotes these processes by activating the Wnt/β-catenin signaling pathway.
Review
Dentistry, Oral Surgery & Medicine
Jingwei Cao, Qiong Zhang, Qiyuan Yang, Yue Yu, Mingmei Meng, Jing Zou
Summary: Periodontitis is an inflammatory disease that causes bone loss in the alveolar region. The differentiation of periodontal ligament stem cells (PDLSCs) into osteoblasts can be regulated by epigenetic mechanisms. This review discusses the role of various epigenetic factors in the osteogenic differentiation of PDLSCs and explores the potential therapeutic applications in periodontitis. Studies on epigenetic regulation and PDLSCs were retrieved from databases, showing that epigenetic factors such as DNMT, KDM6A, HDACi, miRNAs, and lncRNAs can induce osteogenic differentiation in a noninflammatory microenvironment. However, in an inflammatory environment, DNA methylation of osteogenesis-related genes and changes in histone modification and noncoding RNA inhibit the osteogenic differentiation of PDLSCs. The use of epigenetic drugs to regulate abnormal epigenetic status in periodontitis and promote alveolar bone regeneration shows promise.
Article
Dentistry, Oral Surgery & Medicine
Qing Shao, ShiWei Liu, Chen Zou, Yilong Ai
Summary: This study found that miR-590-3p promotes osteogenic differentiation of hPDLSCs in periodontitis by targeting LSD1 transcription and upregulating H3K4me2 methylation to enhance OSX transcription.
Article
Chemistry, Multidisciplinary
Yuting Wen, Mei Zhang, Yangxue Yao, Yang Gao, Xiaolin Zhang, Yunfeng Lin, Xiaoxiao Cai
Summary: The hyperplasia and destruction of synovial tissue have a significant impact on the development of rheumatoid arthritis. Targeting anomalous synovial fibroblast and designing a high bioavailability nano drug delivery system can reduce the dosage for the treatment of rheumatoid arthritis and improve curative effect. The experiment established a nobiletin-loaded tetrahedral framework nucleic acids cargo tank which effectively alleviated the disease development of rheumatoid arthritis by reducing the invasiveness of pathological synovial fibroblast.
CHINESE CHEMICAL LETTERS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Songhang Li, Yuxuan Zhao, Taoran Tian, Tianxu Zhang, Yu Xie, Xiaoxiao Cai
Summary: The use of resorbable sutures for fixing a titanium mesh can achieve similar results to traditional fixation using titanium screws. Although this new fixation method can improve the efficiency of the surgery and reduce the risk of complications, the long-term clinical effects require further follow-up investigation.
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2023)
Article
Polymer Science
Zejian He, Haifeng Shao, Nannan Zhang, Jie Li, Hai Xiao, Tianhang Weng, Mi Zhou, Bianying Wen, Yulong Chen
Summary: This study designed and synthesized three amide nucleating agents with different symmetries to investigate the effect of symmetry on PLLA crystallization. It was found that the C3 symmetric amide structure exhibited the best performance as an efficient nucleation site.
JOURNAL OF POLYMER SCIENCE
(2023)
Review
Engineering, Environmental
Huijuan Wu, Weiqiong Zheng, Ran Zhu, Mi Zhou, Xiancheng Ren, Yinghan Wang, Chong Cheng, Hongju Zhou, Sujiao Cao
Summary: This article comprehensively summarizes and discusses the most important advances in engineering MOF nanoarchitectures for efficient water electrolysis. First, the methods of modulating the coordination structures and metal atom environments of MOF and MOF-derived catalysts are reviewed, and then their applications in water splitting are discussed based on the coordination structure and local atomic environment.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Environmental Sciences
Bing Yang, Mi Zhou, Yuan Meng, Keming Chen, Jie Xu, Xiangfu Huang, Yucheng Liu, Lingli Li, Lili Ma, Mingyan Chen
Summary: Chemical oxidation as a pretreatment for petroleum-contaminated soil, coupled with bioremediation, can have serious impacts on indigenous microorganisms and available nutrients. This study found that hydrogen peroxide treatments significantly promoted the removal of total petroleum hydrocarbons (TPH), especially in the initial days, and also affected the levels of dissolved nutrients. Both chemical oxidation and nutrients contribute to changes in microbial community structure and diversity. However, the long-term effects of H2O2 as a pretreatment had little impact on the soil indigenous microbial community structure and actually facilitated the continuous removal of TPH by indigenous microorganisms.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Engineering, Electrical & Electronic
Runyu Fu, Jianguo Wang, Jianping Wang, Mi Zhou, Cai Li, Yating Zhao, Yadong Fan
Summary: This paper establishes a holistic model of a 500 kV GIS step-up substation equipment in a coastal power plant using the Electromagnetic Transient Program (EMTP). It investigates the VFTO waveform generated in different operations and analyzes its impact on equipment.
IET GENERATION TRANSMISSION & DISTRIBUTION
(2023)
Article
Engineering, Electrical & Electronic
Mi Zhou, Weihan Zhao, Shengquan Zheng, Yongming Guo, Zehong Yang, Jianguo Wang, Li Cai, Yadong Fan
Summary: This study establishes a simulation model to investigate the lightning inductive characteristics between parallel cables. The research findings indicate that an increase in the horizontal distance between cables leads to a decrease in the cable induced voltage. Additionally, linear correlations exist between the height difference or disturbed cable length and the cable induced voltage, reaching maximum when the cables are at the same height and of equal length.
IET SCIENCE MEASUREMENT & TECHNOLOGY
(2023)
Article
Spectroscopy
DongFei Li, Shuo Zhang, Hongsheng Jia, Mingxing Song, Ying Zhang, Haibo Li, Mi Zhou
Summary: In this study, high pressure Raman research was conducted on lithium perchlorate crystal, and it was found that the crystal undergoes phase transformations under different pressure conditions, which has significant implications for its performance.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Engineering, Environmental
Mei Zhang, Yuting Wen, Zhangheng Huang, Xin Qin, Mi Zhou, Dexuan Xiao, Weitong Cui, Zhiqiang Liu, Yunfeng Lin
Summary: A novel nanomedicine was developed for the treatment of rheumatoid arthritis, which carries methotrexate and uses aptamer targeting tumor necrosis factor-alpha. This targeted nanomedicine accumulates in the inflammatory joints, reducing systemic toxicity and decreasing joint damage.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Yangxue Yao, Xiaoyu Lei, Yun Wang, Geru Zhang, Hongxiao Huang, Yuxuan Zhao, Sirong Shi, Yang Gao, Xiaoxiao Cai, Shaojingya Gao, Yunfeng Lin
Summary: Diabetic peripheral neuropathy (DPN) is a major late complication of diabetes, and dysfunctional mitochondria are the key therapeutic target. In this study, a tetrahedral framework nucleic acid carrier was used to encapsulate resveratrol, resulting in enhanced stability and bioavailability. The tFNAs-RSV complex showed promising therapeutic effects in vitro and in mice models of DPN by regulating redox and energy metabolism.
Article
Chemistry, Multidisciplinary
Yu Xie, Jiajun He, Songhang Li, Xingyu Chen, Tianxu Zhang, Yuxuan Zhao, Yunfeng Lin, Xiaoxiao Cai
Summary: A transdermal drug delivery system, composed of tetrahedral framework nucleic acids (tFNAs) and lipoic acid (LA), is developed for the topical treatment of skin photodamage. The tFNAs-LA (TLA) nanocomposite exhibits excellent biocompatibility and various therapeutic effects. In both in vitro and in vivo experiments, TLA promotes tissue healing, inhibits apoptosis activation and reactive oxygen species production, and regulates inflammatory responses.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Shaojingya Gao, Yao Jiang, Yangxue Yao, Songhang Li, Xiaoxiao Cai
Summary: This study aimed to introduce a minimally invasive technique for maxillary sinus floor elevation using the lateral approach (lSFE) and determine factors influencing stability of grafted area in sinus cavity. Thirty patients (30 implants) treated with lSFE using minimally invasive techniques from 2015 to 2019 were included. CBCT was used to measure bone heights (BHs) of implants before surgery, immediately after surgery (T0), 6 months after surgery (T1), and at last follow-up visit (T2). No implant failed during the 3.67±1.75 years of follow-up. Three implants exhibited perforations. BH changes showed strong correlations with each other and decreased before second-stage surgery. RBH did not significantly influence BH changes, while smoking status and type of bone graft materials were potentially influential factors. In conclusion, lSFE using minimally invasive techniques was a viable treatment option with high implant survival rate and limited bone resorption in grafted area.
INTERNATIONAL JOURNAL OF ORAL SCIENCE
(2023)
Article
Pediatrics
Tian Tian, Tongjia Gan, Jun Chen, Jun Lu, Guiling Zhang, Yiran Zhou, Jia Li, Haoyue Shao, Yufei Liu, Hongquan Zhu, Di Wu, Chengcheng Jiang, Jianbo Shao, Jingjing Shi, Wenzhong Yang, Wenzhen Zhu
Summary: An intelligent HIE identification model (DLCRN) based on conventional structural MRI and clinical characteristics was developed and validated in this study. The DLCRN model showed good discrimination, calibration, and clinical applicability in diagnosing HIE. Visualization of the DLCRN highlighted the lesion areas that conformed to radiological identification. Scientific application of the optimized DLCRN model may save time for screening early mild HIE, improve the consistency of HIE diagnosis, and guide timely clinical management.
