Journal
CELL PROLIFERATION
Volume 46, Issue 2, Pages 232-242Publisher
WILEY-BLACKWELL
DOI: 10.1111/cpr.12024
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Funding
- Ministry of Agriculture of China for Transgenic Research Program [2011Z X08009-003-006, 2011ZX08012-002-06]
- central level, scientific research institutes for R & D special fund business [2011cj-9, 2012zl072]
- project of National Infrastructure of Animal Germplasm Resources
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Objectives: Many kinds of cardiac progenitor cell populations have been identified, including c-kit+, Nkx2.5+s and GATA4+ cells. However, these progenitors have limited ability to differentiate into different cardiac cell types. Recently, a new kind of cardiac progenitor cell named the multipotent Isl1+ cardiovascular progenitor (MICPs) has been identified, which also expresses Nkx2.5, GATA4, CD34 and Flk1. Materials and methods: In this study, we have isolated and characterized MICPs from chicken embryonic heart tissues using immunofluorescence and PCR. Results: Results shown that they express markers of cardiac progenitor cells, with high clonality. They have the ability to self-renew and can give rise to three types of heart cell in vitro. Conclusions: Myocytes, smooth muscle cells and endothelial cells. Our work provides evidence for a developmental paradigm of the heart, that endothelial and muscle lineage diversification arises from multipotent cardiac progenitor cells. Existence of these cells provides a new opportunity for myocardial injury repair.
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