Journal
CELL METABOLISM
Volume 18, Issue 2, Pages 151-152Publisher
CELL PRESS
DOI: 10.1016/j.cmet.2013.07.009
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Extensive transcriptional networks maintain sterol homeostasis across species, underscoring the importance of sterol balance for healthy life. Magner et al. (2013) now show that, in C. elegans, the nuclear receptor NHR-8 is key in regulation of cholesterol balance and production of dafachronic acid, a bile acid-like steroid that controls longevity.
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