Journal
CELL METABOLISM
Volume 9, Issue 5, Pages 405-406Publisher
CELL PRESS
DOI: 10.1016/j.cmet.2009.04.005
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Osteoclasts are the primary cells that resorb bone; they require high energy levels to degrade bone matrix, releasing minerals to maintain calcium homeostasis. Recent work on osteoclast differentiation and activity highlights an important role for mitochondrial biogenesis and explores the role of iron transferrin in generating a positive osteoclastogenic feedback loop.
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