Article
Immunology
Nilgun Sallakci, Ilhan Tahrali, Umut Can Kucuksezer, Esin Aktas Cetin, Ahmet Gul, Gunnur Deniz
Summary: This study investigated the activation status and function of NK cells in Behcet's disease patients. The results showed that patients in active and inactive phases displayed different activation levels of NK cells, indicating their potential association with immune attacks and remissions during the course of the disease.
IMMUNOLOGIC RESEARCH
(2022)
Article
Oncology
Zheng Zhu, Kun-Yu Teng, Jian Zhou, Yunyun Xu, Lifeng Zhang, Hua Zhao, Xueguang Zhang, Lei Tian, Zhiyao Li, Ting Lu, Shoubao Ma, Zhenlong Li, Zhenyu Dai, Jing Wang, Xingyu Chen, Xing Wu, Yihan Pan, Weiqiang Shi, Zhiqun You, Hanyu Chen, Vincent Chung, Jianhua Yu, Songbing He, Xin Zhao, Lei Cao, Dechun Li
Summary: B7H6, a member of the B7 family of immunoreceptors, is found to be highly expressed in pancreatic cancer tissues. Its soluble form can be detected in patients' sera, and higher levels are associated with poorer prognosis. In addition to serving as a prognostic marker, B7H6 also acts as an immune modulator in pancreatic cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Alessandro Natoni, Marina Cerreto, Maria Stefania De Propris, Maria Teresa Petrucci, Francesca Fazio, Stefania Intoppa, Maria Laura Milani, Lucy Kirkham-McCarthy, Robert Henderson, Dawn Swan, Anna Guarini, Michael O'Dwyer, Robin Foa
Summary: Multiple myeloma (MM) is a plasma cell disorder characterized by uncontrolled proliferation in the bone marrow and dissemination to different skeletal sites. Sialofucosylated structures, particularly Sialyl Lewis a/x (SLe(a/x)), facilitate the homing of MM cells to the bone marrow and confer resistance to bortezomib. This study demonstrates that SLe(a/x) induces strong binding of MM cells to P-selectin, leading to specific interactions with platelets and protection from natural killer cell-mediated cytotoxicity. These interactions were also observed in MM patient samples, suggesting the importance of SLe(a/x) and platelets in disease progression and therapy resistance.
Article
Gastroenterology & Hepatology
Martin E. Baumdick, Annika Niehrs, Frauke Degenhardt, Maria Schwerk, Ole Hinrichs, Ana Jordan-Paiz, Benedetta Padoan, Lucy H. M. Wegner, Sebastian Schloer, Britta F. Zecher, Jakob Malsy, Vinita R. Joshi, Christin Illig, Jennifer Schroeder-Schwarz, Kimberly J. Moeller, Maureen P. Martin, Yuko Yuki, Mikki Ozawa, Juergen Sauter, Alexander H. Schmidt, Daniel Perez, Anastasios D. Giannou, Mary Carrington, Randall S. Davis, Udo Schumacher, Guido Sauter, Samuel Huber, Victor G. Puelles, Nathaniel Melling, Andre Franke, Marcus Altfeld, Madeleine J. Bunders
Summary: The study identified HLA-DP401 as a risk haplotype and HLA-DP301 as a protective haplotype for UC in European populations. Higher expression of HLA-DP was observed on IECs of individuals with UC compared to controls. Interaction between HLA-DP401 and NKp44 resulted in increased damage to intestinal epithelial cells, while blocking this interaction reduced NK cell-mediated destruction in UC.
Article
Immunology
Gloria Yareli Gutierrez-Silerio, Miriam Ruth Bueno-Topete, Alejandra Natali Vega-Magana, Blanca Estela Bastidas-Ramirez, Jorge Gutierrez-Franco, Marta Escarra-Senmarti, Eliza Julia Pedraza-Brindis, Marcela Pena-Rodriguez, Martha Eloisa Ramos-Marquez, Vidal Delgado-Rizo, Nehla Banu, Alan Guillermo Alejandre-Gonzalez, Mary Fafutis-Morris, Jesse Haramati, Susana del Toro-Arreola
Summary: The NKp30 receptor, encoded by the NCR3 gene, is expressed in NK cells and has three isoforms. Increased expression of these isoforms and low levels of the NKp30 ligand B7H6 have been associated with positive prognosis in different cancer types. In cervical cancer patients, a distinct immune down-modulation or non-fitness status was observed, with decreased NKp30(+) NK cells and lower perforin levels. Cervical cancer patients also exhibited decreased expression of the NKp30 C isoform and overexpression of soluble B7H6, highlighting the importance of understanding this immune response for the development of novel immunotherapies.
Article
Immunology
Hanqing Chen, Yang Zhang, Yu Shen, Liang Jiang, Guangbo Zhang, Xueguang Zhang, Yang Xu, Fengqing Fu
Summary: This study reveals the existence of N-glycosylation in the novel immune checkpoint molecule B7-H6. It shows that N43 and N208 glycosylation are essential for the stability and membrane expression of B7-H6. Lack of N208 glycosylation leads to membrane shedding, while N43 mutation impairs the binding affinity with NKp30. These findings highlight the significance of N-linked glycosylation in the biological functions of B7-H6 and suggest potential targets for modulating NK cell-mediated immunity.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Hongwei Jiang, Jingting Jiang
Summary: NK cells are fundamental components of innate immunity and have regulatory functions in both innate and adaptive immunity. This review integrates multiple studies to illuminate the regulatory function of NK cells in the adaptive immune responses of B cells and T cells, with a focus on viral infections and the tumor microenvironment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Barbora Kalouskova, Ondrej Skorepa, Denis Cmunt, Celeste Abreu, Katerina Krejcova, Jan Blaha, Irena Sieglova, Vlastimil Kral, Milan Fabry, Robert Pola, Michal Pechar, Ondrej Vanek
Summary: This study demonstrates the conjugation of immunologically active protein B7-H6 with a polymer to activate NK cells and induce apoptosis of tumor cells. By optimizing expression and binding experiments, the potential application of this chimeric biopolymer in cancer immunotherapy has been shown.
Article
Chemistry, Multidisciplinary
Siyuan Pan, Changyi Liu, Huan Yao, Xingyu Pan, Jinhang Li, Jinlei Yang, Murong Du, Peng Liu, Sichun Zhang, Xinrong Zhang
Summary: A lymphocyte classification method based on single-cell metabolite profiling is proposed, which is verified to be feasible for the classification of lymphocyte subtypes. This method is expected to be a potential tool for the clinical diagnosis of lymphocyte-related diseases.
CHEMICAL COMMUNICATIONS
(2023)
Article
Oncology
Markella Zannikou, Joseph T. Duffy, Rebecca N. Levine, Maggie Seblani, Qianli Liu, Aaron Presser, Victor A. Arrieta, Christopher J. Chen, Adam M. Sonabend, Craig M. Horbinski, Catalina Lee-Chang, Jason Miska, Maciej S. Lesniak, Stephen Gottschalk, Irina Balyasnikova
Summary: This study found that IL15 can potentially be used to directly target myeloid-derived suppressor cells (MDSCs) in the immunosuppressive tumor microenvironment (TME) of glioblastoma (GBM). IL15-modified CAR-T cells efficiently depleted MDSCs and significantly improved survival in GBM mouse models. The results suggest that IL15-modified CAR-T cells have dual targeting effects against tumor cells and MDSCs in GBM, warranting further evaluation in early-phase clinical studies.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Immunology
Elena Pontarini, Elisabetta Sciacca, Sofia Grigoriadou, Felice Rivellese, Davide Lucchesi, Liliane Fossati-Jimack, Rachel Coleby, Farzana Chowdhury, Francesca Calcaterra, Anwar Tappuni, Myles J. Lewis, Martina Fabris, Luca Quartuccio, Silvia Della Bella, Simon Bowman, Costantino Pitzalis, Domenico Mavilio, Salvatore De Vita, Michele Bombardieri
Summary: The levels of NCR3/NKp30 were significantly increased in salivary glands and circulating NK cells of pSS patients, correlating with higher levels of IFN-gamma and other immune cells, especially in salivary glands with organized ectopic lymphoid structures.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Developmental Biology
Elena Melendez, Dafni Chondronasiou, Lluc Mosteiro, Jaime Martinez de Villarreal, Marcos Fernandez-Alfara, Cian J. Lynch, Dirk Grimm, Francisco X. Real, Jose Alcami, Nuria Climent, Federico Pietrocola, Manuel Serrano
Summary: The presence of natural killer (NK) cells significantly hampers the reprogramming of cells, both in vitro and in vivo. NK cells recognize and kill partially reprogrammed cells, leading to a decrease in in vivo reprogramming. Depletion of NK cells increases the efficiency of in vivo reprogramming.
Article
Genetics & Heredity
Morgan E. Janes, Allison Kinlein, Martin F. Flajnik, Louis Du Pasquier, Yuko Ohta
Summary: This research identifies the presence of the NKp30 receptor and its related gene NCR3H in vertebrates, and these genes are clustered with immune-related genes in the ancestral MHC region. The study also finds that these gene complexes are present in invertebrates, suggesting that these cellular networks emerged early in the evolution of gnathostomes.
Review
Immunology
Massimo Fantini, Philip Martin Arlen, Kwong Yok Tsang
Summary: Natural killer (NK) cells are important components of the innate immune system that can recognize and suppress the proliferation of cancer cells. Strategies such as boosting NK cells with modulatory cytokines, adoptive NK cell therapy, and the combination of engineered NK cells with monoclonal antibodies (mAbs) that mediate antibody-dependent cell-mediated cytotoxicity (ADCC) have been developed to enhance the antitumor activity of NK cells. The combination of engineered NK cells with mAbs with higher affinity for CD16 expressed on NK cells shows promise in providing more effective and higher-quality treatments for cancer patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Hao Guan, Qiaogan Liao, Tianhuan Huang, Shuang Geng, Ziliang Cao, Zheling Zhang, Dongjie Wang, Jian Zhang
Summary: Additive strategies are crucial for improving the performance of organic solar cells (OSCs). This study focuses on the application of a solid additive, BTA3, in PM6:BTP-eC9-based OSCs, resulting in a high energy conversion efficiency of 18.65%. BTA3 improves compatibility with the acceptor component, optimizes film morphology, promotes exciton dissociation and charge transfer, and suppresses charge recombination.
ACS APPLIED MATERIALS & INTERFACES
(2023)
