Inhibition of autophagy, lysosome and VCP function impairs stress granule assembly

Neuronal-Specific Overexpression of a Mutant Valosin-Containing Protein Associated with IBMPFD Promotes Aberrant Ubiquitin and TDP-43 Accumulation and Cognitive Dysfunction in Transgenic Mice

(2013) Carlos J. Rodriguez-Ortiz et al.   AMERICAN JOURNAL OF PATHOLOGY

Molecular Chaperone Functions in Protein Folding and Proteostasis

(2013) Yujin E. Kim et al.   Annual Review of Biochemistry

Eukaryotic Stress Granules Are Cleared by Autophagy and Cdc48/VCP Function

(2013) J. Ross Buchan et al.   CELL

Inhibition of mTORC1 by Astrin and Stress Granules Prevents Apoptosis in Cancer Cells

(2013) Kathrin Thedieck et al.   CELL

Structure-Activity Relationship Study Reveals ML240 and ML241 as Potent and Selective Inhibitors of p97 ATPase

(2013) Tsui-Fen Chou et al.   ChemMedChem

Coordination of Translational Control and Protein Homeostasis during Severe Heat Stress

(2013) Valeria Cherkasov et al.   CURRENT BIOLOGY

The p97-UBXD8 complex destabilizes mRNA by promoting release of ubiquitinated HuR from mRNP

(2013) H.-L. Zhou et al.   GENES & DEVELOPMENT

Stress granules as crucibles of ALS pathogenesis

(2013) Yun R. Li et al.   JOURNAL OF CELL BIOLOGY

The Mechanism and Physiological Function of Macroautophagy

(2013) Daniel J. Klionsky et al.   Journal of Innate Immunity

Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS

(2013) Hong Joo Kim et al.   NATURE

Cdc48-associated complex bound to 60S particles is required for the clearance of aberrant translation products

(2013) Q. Defenouillere et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome

(2013) Rati Verma et al.   eLife

40S subunit dissociation and proteasome-dependent RNA degradation in nonfunctional 25S rRNA decay

(2012) Kotaro Fujii et al.   EMBO JOURNAL

Arsenite interferes with protein folding and triggers formation of protein aggregates in yeast

(2012) T. Jacobson et al.   JOURNAL OF CELL SCIENCE

Stress Granules Inhibit Apoptosis by Reducing Reactive Oxygen Species Production

(2012) M. Takahashi et al.   MOLECULAR AND CELLULAR BIOLOGY

Large G3BP-induced granules trigger eIF2α phosphorylation

(2012) Lucas C. Reineke et al.   MOLECULAR BIOLOGY OF THE CELL

Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system

(2012) Hemmo Meyer et al.   NATURE CELL BIOLOGY

Cdc48/p97, a key actor in the interplay between autophagy and ubiquitin/proteasome catabolic pathways

(2011) Catherine Dargemont et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Autophagosome Precursor Maturation Requires Homotypic Fusion

(2011) Kevin Moreau et al.   CELL

Imaging protein synthesis in cells and tissues with an alkyne analog of puromycin

(2011) J. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy

(2010) Terje Høyvarde Clausen et al.   Autophagy

Cdc48 and Ufd3, new partners of the ubiquitin protease Ubp3, are required for ribophagy

(2010) Batool Ossareh-Nazari et al.   EMBO REPORTS

The ROQUIN family of proteins localizes to stress granules via the ROQ domain and binds target mRNAs

(2010) Vicki Athanasopoulos et al.   FEBS Journal

Inclusion body myopathy, Paget's disease of the bone and fronto-temporal dementia: a disorder of autophagy

(2010) J. S. Ju et al.   HUMAN MOLECULAR GENETICS

Respiratory Syncytial Virus Induces Host RNA Stress Granules To Facilitate Viral Replication

(2010) M. E. Lindquist et al.   JOURNAL OF VIROLOGY

Exome Sequencing Reveals VCP Mutations as a Cause of Familial ALS

(2010) Janel O. Johnson et al.   NEURON

Stress granules

(2009) Paul Anderson et al.   CURRENT BIOLOGY

Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease

(2009) Jeong-Sun Ju et al.   JOURNAL OF CELL BIOLOGY

A Role for Ubiquitin in Selective Autophagy

(2009) Vladimir Kirkin et al.   MOLECULAR CELL

Autophagy Inhibition Compromises Degradation of Ubiquitin-Proteasome Pathway Substrates

(2009) Viktor I. Korolchuk et al.   MOLECULAR CELL

Discovery of Atg5/Atg7-independent alternative macroautophagy

(2009) Yuya Nishida et al.   NATURE

Metazoan stress granule assembly is mediated by P-eIF2 -dependent and -independent mechanisms

(2009) N. G. Farny et al.   RNA

Impaired Protein Aggregate Handling and Clearance Underlie the Pathogenesis of p97/VCP-associated Disease

(2008) Jeong-Sun Ju et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mature ribosomes are selectively degraded upon starvation by an autophagy pathway requiring the Ubp3p/Bre5p ubiquitin protease

(2008) Claudine Kraft et al.   NATURE CELL BIOLOGY

A functional RNAi screen links O-GlcNAc modification of ribosomal proteins to stress granule and processing body assembly

(2008) Takbum Ohn et al.   NATURE CELL BIOLOGY

Stress granules: the Tao of RNA triage

(2008) Paul Anderson et al.   TRENDS IN BIOCHEMICAL SCIENCES