MDM2 restrains estrogen-mediated AKT activation by promoting TBK1-dependent HPIP degradation

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A Network of Substrates of the E3 Ubiquitin Ligases MDM2 and HUWE1 Control Apoptosis Independently of p53

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IKBKE Protein Activates Akt Independent of Phosphatidylinositol 3-Kinase/PDK1/mTORC2 and the Pleckstrin Homology Domain to Sustain Malignant Transformation

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Functional Regulation of Pre-B-cell Leukemia Homeobox Interacting Protein 1 (PBXIP1/HPIP) in Erythroid Differentiation

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TBK1 Directly Engages Akt/PKB Survival Signaling to Support Oncogenic Transformation

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BCL-3 Degradation Involves Its Polyubiquitination through a FBW7-independent Pathway and Its Binding to the Proteasome Subunit PSMB1

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The Repressing Function of the Oncoprotein BCL-3 Requires CtBP, while Its Polyubiquitination and Degradation Involve the E3 Ligase TBLR1

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The E3 Ligase TTC3 Facilitates Ubiquitination and Degradation of Phosphorylated Akt

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Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

(2009) David A. Barbie et al.   NATURE

Matrix Metalloproteinase-9 gene induction by a truncated oncogenic NF-κB2 protein involves the recruitment of MLL1 and MLL2 H3K4 histone methyltransferase complexes

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(2008) Sharmila Patel et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation

(2008) Jer-Yen Yang et al.   NATURE CELL BIOLOGY

PI3K pathway alterations in cancer: variations on a theme

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