Article
Chemistry, Medicinal
Gillian E. Conway, Deimante Zizyte, Julie Rose Mae Mondala, Zhonglei He, Lorna Lynam, Mathilde Lecourt, Carlos Barcia, Orla Howe, James F. Curtin
Summary: The study demonstrates that ursolic acid rapidly induces lysosomal-associated cell death and inhibits cell migration in glioblastoma, indicating a potential therapeutic target in cancer treatment.
Article
Cell Biology
Juergen Fritsch, Julia Frankenheim, Lothar Marischen, Timea Vadasz, Anja Troeger, Stefan Rose-John, Dirk Schmidt-Arras, Wulf Schneider-Brachert
Summary: ADAM17 plays a key role in fine-tuning death receptor signaling, and its absence can increase cell death. A better understanding of TNF-R1 superfamily receptor decisions may lead to more effective treatments for infectious, inflammatory diseases, or cancer.
Article
Oncology
Chao Zeng, Zhixuan Zhang, Wei Luo, Liyang Wang, Hang Zhou, Chunlai Nie
Summary: ABT-199 activates the JNK-Akt-14-3-3 signaling pathway to induce Beclin-1-dependent autophagic death in solid tumors.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Cell Biology
Xue-Hua Du, Shao-Bo Ke, Xin-Yi Liang, Jie Gao, Xiao-Xiao Xie, Lin-Zhi Qi, Xue-Yi Liu, Guo-Yuan Xu, Xiao-Dong Zhang, Run-Lei Du, Shang-Ze Li
Summary: Our study demonstrates that USP14 functions as a deubiquitinase that interacts and stabilizes JNK, promoting MAPK/JNK signaling and colorectal carcinogenesis. Increased expression of USP14 is associated with elevated levels of JNK protein and downstream gene expression in colorectal cancer patients. Inhibition of USP14 reduces cancer cell proliferation and tumorigenesis by downregulating the activation of the MAPK/JNK pathway.
CELL DEATH & DISEASE
(2023)
Article
Environmental Sciences
Yang Yu, Periyannan Velu, Yulong Ma, Annamalai Vijayalakshmi
Summary: The study aimed to investigate the effects of nerolidol on osteosarcoma MG-63 cells, demonstrating inhibition of cell proliferation and induction of apoptosis. Additionally, nerolidol was found to suppress osteosarcoma cells by regulating the PI3K/AKT protein and inducing cell cycle arrest. These findings suggest that nerolidol may be a potential drug for future chemotherapeutic purposes in bone cancer treatment.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zhengcheng Wang, Xiang Ao, Zhilin Shen, Luoquan Ao, Xiaofeng Wu, Chengxiu Pu, Wei Guo, Wei Xing, Min He, Hongfeng Yuan, Jianhua Yu, Ling Li, Xiang Xu
Summary: Chronic inflammation-induced metastases in cancer have been a significant obstacle in treatment. Recent studies have shown that TNF-alpha activates PI3K/Akt and p38 MAPK pathways to enhance CXCL10 transcription, promoting metastases in colon cancer cells. CXCL10, in turn, regulates EMT in colon cancer cells via the PI3K/Akt pathway, offering a new potential target for inhibiting colon cancer metastases.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Salvador C. Herrera, Erika A. Bach
Summary: The JNK pathway plays essential roles in stem cell biology, involving processes such as proliferation, death, and cellular plasticity. Studies using Drosophila models have revealed new functions and mechanisms of JNK signaling in stem cells, highlighting its significance in regenerative responses and reprogramming.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Suwen Ou, Haipeng Chen, Hufei Wang, Jinhua Ye, Huidi Liu, Yangbao Tao, Songlin Ran, Xiaoqin Mu, Fangzhou Liu, Shuang Zhu, Kangjia Luo, Zilong Guan, Yinghu Jin, Rui Huang, Yanni Song, Shu-lin Liu
Summary: The study found that Fusobacterium nucleatum (F. nucleatum) can promote migration and metastasis of colorectal cancer (CRC) cells by upregulating Matrix metalloproteinase 7 (MMP7), and F. nucleatum and MMP7 may serve as potential therapeutic targets for suppressing CRC progression and metastasis.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Immunology
Sam Blanchett, Yves Dondelinger, Alessandro Barbarulo, Mathieu J. M. Bertrand, Benedict Seddon
Summary: The IKK complex plays a critical role in regulating NF-kappa B activation. It has been found that IKK can also repress RIPK1 dependent cell death pathways by phosphorylating RIPK1 at serine 25. This phosphorylation event promotes the survival of T cells and is essential for normal development in the thymus.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Genetics & Heredity
Kiichiro Taniguchi, Tatsushi P. Igaki
Summary: In this study, the role of apoptosis in the formation of the germ-line stem cell (GSC) niche was analyzed in Drosophila ovarian development. It was found that the transmembrane protein Sas and its ligand Ptp10D facilitate JNK-mediated apoptosis, helping to shape the GSC niche with a specific structure. Loss of apoptosis results in abnormal GSC niche shaping, leading to increased GSC numbers and decreased egg production, indicating the crucial importance of niche structure for maintaining the function of the stem cell system.
Article
Biochemistry & Molecular Biology
Yang Zhao, Yao Chen, Xiangsheng Li, Yizhao Sun, Yuxin Shao, Yanfen Zhang, Zhongcheng Liu
Summary: This study utilized HaCaT cell models to demonstrate that knockout of RIPK1 resulted in slowed cell proliferation and G2M phase blockade, increased sensitivity to TNF-alpha-induced cell death and apoptosis, possibly linked to NF-kappa B pathway inhibition. RIPK1 knockout also significantly inhibited cell growth and up-regulated IL-1 alpha expression in response to UVB, possibly involving P38 MAPK and NF-kappa B pathways. Furthermore, RIPK1 in epidermal cells was found to have a regulatory function on prosurvival signals.
MOLECULAR IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Yuan-Ru Chen, Shu-Chi Wang, Shu-Pin Huang, Chia-Cheng Su, Po-Len Liu, Wei-Chung Cheng, Chih-Pin Chuu, Jen-Kun Chen, Bo-Ying Bao, Cheng Hsueh Lee, Chien-Chih Ke, Hsin-En Wu, Hao-Han Chang, Hsin-Chih Yeh, Chia-Yang Li
Summary: This study found that Protodioscin has inhibitory effects on cell proliferation, migration, invasion, and EMT in bladder cancer cells. Moreover, Protodioscin can induce cell apoptosis and arrest cell cycle progression, and it exerts its anti-cancer effects through regulating the MAPK and PI3K/AKT/mTOR signaling pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Shengnan Wang, Xuelei Chen, Jin Cheng, Tianyu Cai, Xiaoming Wu, Zhenyu Cheng, Shimei Qi, Zhilin Qi
Summary: This study demonstrated that Calenduloside E reduced proliferation and migration of HepG2 cells through the p38/JNK-HMGB1 signaling axis, providing a new perspective on the anti-tumor molecular mechanism of CE in Hepatocellular carcinoma.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2021)
Article
Cell Biology
Zehra Ali-Murthy, Richard D. Fetter, Wanpeng Wang, Bin Yang, Loic A. Royer, Thomas B. Kornberg
Summary: During Drosophila oocyte development, germline nurse cells pass products to the oocyte through intercellular bridges. At an early stage, two nurse cells fuse with the oocyte and extrude their nuclei, paving the way for subsequent development. Failure to eliminate nurse cell nuclei at the right stage results in abnormal morphology in the developing oocyte.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Cell Biology
Guole Liu, Yan Qi, Jiandong Wu, Francis Lin, Zhonghui Liu, Xueling Cui
Summary: It was found in this study that FST, rather than activin A, played a crucial role in the migration of decidualized endometrial stromal cells through JNK signaling, by increasing calcium influx and upregulating the expression levels of migration-related proteins MMP9 and Ezrin. This finding helps to enhance our understanding of the mechanisms underlying uterine decidualization and tissue remodeling during pregnancy.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Multidisciplinary Sciences
Xianjue Ma, Xiaowei Guo, Helena E. Richardson, Tian Xu, Lei Xue
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Biochemistry & Molecular Biology
Shiping Zhang, Xiaowei Guo, Honggui Wu, Ying Sun, Xianjue Ma, Jikai Li, Qian Xu, Chenxi Wu, Qiwen Li, Cizhong Jiang, Wenzhe Li, Margaret S. Ho, Zhongwei Lv, Lei Xue
Article
Cell Biology
Ketu Mishra-Gorur, Daming Li, Xianjue Ma, Yanki Yarman, Lei Xue, Tian Xu
DISEASE MODELS & MECHANISMS
(2019)
Article
Biochemistry & Molecular Biology
Xianjue Ma, Jin-Yu Lu, Alexandra Moraru, Aurelio A. Teleman, Jinan Fang, Yue Qiu, Peng Liu, Tian Xu
Article
Multidisciplinary Sciences
Xiaowei Guo, Yihao Sun, Taha Azad, H. J. Janse van Rensburg, Jingjing Luo, Shuai Yang, Peng Liu, Zhongwei Lv, Meixiao Zhan, Ligong Lu, Yingqun Zhou, Xianjue Ma, Xiaoping Zhang, Xiaolong Yang, Lei Xue
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Cell Biology
Du Kong, Jin-Yu Lu, Xiaoqin Li, Sihua Zhao, Wenyan Xu, Jinan Fang, Xing Wang, Xianjue Ma
Summary: The study identified Msn as a tumor suppressor that synergizes with oncogenic Ras to induce JNK activation and Hippo inactivation, leading to tumor overgrowth and invasion. Msn can activate the Hippo signaling pathway to suppress overgrowth induced by disruption of Hippo signaling.
Article
Cell Biology
Xianping Wang, Hui Liang, Wenyan Xu, Xianjue Ma
Summary: Both Hippo signaling pathways and cell polarity regulation are vital for cell proliferation and tissue homeostasis. This study uncovers the Wnd-Nmo axis as a crucial molecular link between loss-of-cell polarity-triggered Hippo inactivation and overgrowth in Drosophila, providing new insights into how cell polarity loss contributes to overgrowth.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Weixiang Bian, Mengfan Tang, Hua Jiang, Wenyan Xu, Wanyu Hao, Yue Sui, Yingnan Hou, Litong Nie, Huimin Zhang, Chao Wang, Nan Li, Jiadong Wang, Jun Qin, Lianfeng Wu, Xianjue Ma, Junjie Chen, Wenqi Wang, Xu Li
Summary: The Notch signaling pathway plays a crucial role in cell growth, differentiation, and disease progression. Research has identified LRP1 as a critical regulator of the Notch pathway, with LRP1 inhibition showing potential for reducing cancer development.
DEVELOPMENTAL CELL
(2021)
Article
Biochemistry & Molecular Biology
Yu Pan, Wanzhen Li, Zhu Deng, Yihao Sun, Xianjue Ma, Ruijuan Liang, Xiaowei Guo, Ying Sun, Wenzhe Li, Renjie Jiao, Lei Xue
Summary: Despite natural selection, same-sex sexual attraction is common across animals. This study reveals that the proto-oncogene Myc inhibits male-male courtship in fruit flies by acting in dopaminergic neurons. This finding highlights the crucial roles of genetic factors in inter-male sexual behavior.
Article
Multidisciplinary Sciences
Xiaowei Guo, Zhuojie Li, Xiaojie Zhu, Meixiao Zhan, Chenxi Wu, Xiang Ding, Kai Peng, Wenzhe Li, Xianjue Ma, Zhongwei Lv, Ligong Lu, Lei Xue
Summary: Autophagy is a degradation process that regulates various physiological and pathological activities. SNAI2, a crucial factor in cancer progression, has been identified as a regulator of autophagy. The binding of DNA targets is critical for FOXO3 to regulate protein nuclear localization, and SNAI2 expression is mediated by FOXO3. These findings reveal a new regulatory loop for inducing autophagy gene expression under energy stress.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
Du Kong, Sihua Zhao, Wenyan Xu, Jinxi Dong, Xianjue Ma
Summary: This study identifies Toll-6 as a key regulator of tumor-suppressive cell competition through the Toll-6-a-Spec axis. Toll-6 increases mechanical tension by interacting with a-Spec and activates the Hippo pathway, leading to the elimination of polarity-deficient tumor cells.
Article
Cell Biology
Peng Liu, Yifan Guo, Wenyan Xu, Sha Song, Xiaoqin Li, Xing Wang, Jinyu Lu, Xiaowei Guo, Helena E. Richardson, Xianjue Ma
Summary: Ptp61F is identified as a pivotal regulator of organ size that controls 3D organ size under both physiological and pathological conditions, integrating multiple signaling pathways for regulation.
Editorial Material
Biochemistry & Molecular Biology
Shuai Yang, Yifan Guo, Xianjue Ma
Article
Cell Biology
Jiadong Zheng, Yifan Guo, Changyi Shi, Shuai Yang, Wenyan Xu, Xianjue Ma
Summary: This study reveals the important role of Ire1 in cell competition, regulating the fate of loser cells through controlling apoptosis and autophagy, and provides molecular insights into scrib-mediated TSCC.
Editorial Material
Cell Biology
Xianjue Ma