Acidotoxicity and acid-sensing ion channels contribute to motoneuron degeneration

Amyotrophic Lateral Sclerosis and Excitotoxicity: From Pathological Mechanism to Therapeutic Target

(2012) E. Bogaert et al.   CNS & Neurological Disorders-Drug Targets

Heteromeric Acid-Sensing Ion Channels (ASICs) Composed of ASIC2b and ASIC1a Display Novel Channel Properties and Contribute to Acidosis-Induced Neuronal Death

(2011) T. W. Sherwood et al.   JOURNAL OF NEUROSCIENCE

Cross-reactivity of acid-sensing ion channel and Na+-H+exchanger antagonists with nicotinic acetylcholine receptors

(2011) Julio Santos-Torres et al.   JOURNAL OF PHYSIOLOGY-LONDON

The effects of dexpramipexole (KNS-760704) in individuals with amyotrophic lateral sclerosis

(2011) Merit Cudkowicz et al.   NATURE MEDICINE

Guidelines for preclinical animal research in ALS/MND: A consensus meeting

(2010) Albert C. Ludolph et al.   Amyotrophic Lateral Sclerosis

Activation of Acid-sensing Ion Channel 1a (ASIC1a) by Surface Trafficking

(2010) Sunghee Chai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Energy metabolism in amyotrophic lateral sclerosis

(2010) Luc Dupuis et al.   LANCET NEUROLOGY

Misfolded Mutant SOD1 Directly Inhibits VDAC1 Conductance in a Mouse Model of Inherited ALS

(2010) Adrian Israelson et al.   NEURON

Angiogenin protects motoneurons against hypoxic injury

(2009) J Sebastià et al.   CELL DEATH AND DIFFERENTIATION

Recent advances in motor neuron disease

(2009) Philip Van Damme et al.   CURRENT OPINION IN NEUROLOGY

Identification of Protein Domains That Control Proton and Calcium Sensitivity of ASIC1a

(2009) Thomas Sherwood et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ASIC2 Subunits Target Acid-Sensing Ion Channels to the Synapse via an Association with PSD-95

(2009) X.-m. Zha et al.   JOURNAL OF NEUROSCIENCE

Design, power, and interpretation of studies in the standard murine model of ALS

(2008) Sean Scott et al.   Amyotrophic Lateral Sclerosis

NMDA receptor-mediated excitotoxic neuronal apoptosis in vitro and in vivo occurs in an ER stress and PUMA independent manner

(2008) Caoimhín G. Concannon et al.   JOURNAL OF NEUROCHEMISTRY

Control of Motoneuron Survival by Angiogenin

(2008) D. Kieran et al.   JOURNAL OF NEUROSCIENCE