Article
Multidisciplinary Sciences
Jiao Luo, Xiujun Tan, Ling Ye, Chenglin Wang
Summary: The study reveals that the JNK signaling pathway plays a positive role in the formation of dental papilla cell polarity, as indicated by the up-regulation of polarity-related genes and rescue effects of RhoA Q63L mutant. JNK activation is linked to polarization, migration, and differentiation of dental papilla cells, highlighting its importance in tooth development.
Article
Hematology
Ronen Siman-Tov, Natalie Zelikson, Michal Caspi, Yakir Levi, Chava Perry, Fayhaa Khair, Hagit Stauber, Josue Sznitman, Rina Rosin-Arbesfeld
Summary: This study demonstrates the expression of components of the noncanonical Wnt pathway in erythrocytes and shows that Wnt ligands can enhance the flexibility and strength of erythrocyte cytoskeleton, leading to prolonged survival in the circulation. The research also indicates that Wnt-5A ligand is secreted into plasma, with monocytes and lymphocytes as possible sources, highlighting potential new avenues for studying signaling pathways in the bloodstream.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jing Tan, Wei Gao, Wanchao Yang, Xianzhang Zeng, Linlin Wang, Xiaoguang Cui
Summary: JNK1 exacerbates ischemia-reperfusion injury in lung transplantation, while JNK2 alleviates it. JNK1 silencing attenuates lung graft dysfunction by inhibiting inflammation and apoptosis.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Pharmacology & Pharmacy
Qihong Yang, Tong Qin, Tao An, Hongna Wu, Gang Xu, Jin Xiang, Kangfan Lei, Shaohua Zhang, Jie Xia, Guifeng Su, Dan Wang, Minggao Xue, Lingmei Kong, Wenxuan Zhang, Song Wu, Yan Li
Summary: In this study, researchers designed a series of pyridonyl acetamide compounds and discovered a novel PORCN inhibitor WHN-88 with a unique di-iodinated pyridone structural fragment. WHN-88 effectively abolished palmitoylation of Wnt ligands and prevented their secretion and the subsequent Wnt/13-catenin signaling transduction. Furthermore, WHN-88 demonstrated potent efficacy against Wnt-driven cancers and inhibited cancer cell stemness.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Deyu Zhang, Qiwei Jiang, Xiangwei Ge, Yanzhu Shi, Tianxing Ye, Yue Mi, Tian Xie, Qihong Li, Qinong Ye
Summary: The study revealed a critical role of RHOV in LUAD metastasis, suggesting it as a potential biomarker for patient prognosis and a therapeutic target.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jie Chen, Hui Li, Changming Yang, Yinjia He, Tatsuo Arai, Qiang Huang, Xiaodong Liu, Linqing Miao
Summary: Traumatic nerve injury activates cell stress pathways, resulting in neuronal death and loss of vital neural functions. This study found that the citrus component naringenin provides neuroprotection through the inhibition of JUN phosphorylation in the JNK-JUN pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Integrative & Complementary Medicine
Hongling Zhou, Tangjia Yang, Zibin Lu, Xuemei He, Jingyu Quan, Shanhong Liu, Yuyao Chen, Kangtai Wu, Huihui Cao, Junshan Liu, Linzhong Yu
Summary: The main bioactive compound in licorice, liquiritin (LQ), has significant anti-inflammatory effects against acute lung injury (ALI) induced by lipopolysaccharide (LPS). It inhibits the activation of the JNK/Nur77/c-Jun signaling pathway, suggesting that LQ may be a potential therapeutic candidate for ALI and inflammatory disorders.
Article
Immunology
Chandrakanth Reddy Edamakanti, Vishwa Mohan, Puneet Opal
Summary: Using human SCA autopsy samples, researchers discovered inflammatory JNK-dependent c-Jun phosphorylation in Bergmann glia, and inhibiting the JNK pathway reduced Bergmann glia inflammation and improved the SCA1 phenotype both behaviorally and pathologically, suggesting a causal role for Bergmann glia inflammation in SCA1 and a potential therapeutic strategy.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Medicine, Research & Experimental
Yuliu Zhang, Jianping Du, Xiaofan Duan, Wei Peng, Lei Lv, Zhiyu Chen, Yumei Zhang
Summary: In this study, RIPK1 expression was found to significantly contribute to cisplatin-induced apoptosis in human ESCC cells. Reduced RIPK1 expression promoted cell proliferation, while overexpressed RIPK1 facilitated apoptosis. Mechanistic investigations revealed that inhibition of RIPK1 proliferation in ESCC cells was regulated through activation of the c-Jun NH2-terminal kinase signaling pathway, leading to mitochondrial damage, ATP depletion, and increased reactive oxygen species generation.
Article
Pharmacology & Pharmacy
Fang Liu, Yan Liu, Qifeng Peng, Guodong Wang, Qing Tan, Zhongyue Ou, Qishan Xu, Chixiang Liu, Daming Zuo, Jianbo Zhao
Summary: This study revealed that creatinine is closely related to drug-induced liver injury and exacerbates APAP-induced hepatocyte death by promoting the production and activation of reactive oxygen species and c-Jun N-terminal kinase.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Pei Xie, Li-Jun Yan, Hong-Ling Zhou, Hui-Hui Cao, Yuan-Ru Zheng, Zi-Bin Lu, Hua-Yi Yang, Jia-Mei Ma, Yu-Yao Chen, Chuying Huo, Chunyang Tian, Jun-Shan Liu, Lin-Zhong Yu
Summary: This study found that emodin protects against LPS-induced acute lung injury (ALI) by regulating the JNK/Nur77/c-Jun signaling pathway. The results of this study indicate the potential of emodin in the treatment of ALI.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Zimin Xiang, Shuai Zhang, Xiaodong Yao, Libin Xu, Jianwei Hu, Chenghui Yin, Jianmei Chen, Hao Xu
Summary: Resveratrol can promote function recovery and axonal regeneration, improve histological damage, and inhibit apoptosis level after SCI by regulating the Wnt/beta-catenin signaling pathway. This study expanded the regulatory mechanism of resveratrol in SCI injury.
Article
Pharmacology & Pharmacy
Huihui Wang, Chuangyu Wen, Siyu Chen, Weiqian Li, Qiyuan Qin, Lu He, Fang Wang, Junxiong Chen, Weibiao Ye, Wende Li, Junsheng Peng, Xiangling Yang, Huanliang Liu
Summary: The study demonstrates that chaetocin induces apoptosis in CRC cells by causing ROS accumulation and activating the JNK/c-Jun pathway, while also down-regulating CD47 expression and enhancing macrophages phagocytosis of CRC cells. Additionally, chaetocin inhibits tumor growth in CRC xenograft models, suggesting its potential as a candidate for CRC chemotherapy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yuwei Jiang, Jiaoya Xu, Ping Huang, Lili Yang, Yang Liu, Yiping Li, Jue Wang, Haiyan Song, Peiyong Zheng
Summary: This study confirms that mitochondrial dysfunction induced by the JNK/Sab signaling pathway plays a crucial role in the development of NASH. Scoparone, by suppressing this signaling pathway, can partially improve the lipotoxic liver injury, making it a potential therapeutic compound for NASH.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Dexun Hao, Yanshuang Li, Jiang Shi, Junguang Jiang
Summary: Baicalin was found to improve lung function by reducing inflammatory cell infiltration and levels of Muc5AC, TNF-alpha, IL-6, and IL-8 in mice. It also increased cell viability, inhibited apoptosis, and decreased levels of inflammatory cytokines in MLE-12 cells. Baicalin upregulated HSP72 expression, which in turn inhibited JNK signaling activation, ultimately alleviating COPD.
MOLECULAR MEDICINE
(2021)
Review
Clinical Neurology
Jian-Qiang Lu, Kaiyun Yang, Kesava K. V. Reddy, Bill Hao Wang
Summary: Calcifying pseudoneoplasm of the neuraxis (CAPNON) is a rare lesion with unknown pathogenesis. We report a unique case of incidental multifocal CAPNON, suggesting a reactive process in its pathogenesis.
BRITISH JOURNAL OF NEUROSURGERY
(2023)
Article
Multidisciplinary Sciences
Shreeya Kedia, Sarah L. Erickson, Guang Yang
Summary: The proper development of the mammalian brain relies on a fine balance of neural stem cell proliferation and differentiation into different neural cell types, which is controlled by gene expression at multiple levels including transcription, post-transcription, and translation. Translational regulation plays a critical role in coordinating neural stem cell fate decisions, and polysome fractionation is a powerful tool for evaluating mRNA translational status. The polysome profiling pipeline presented in this study includes sucrose gradient preparation, tissue lysis, ultracentrifugation, and fractionation-based analysis of mRNA translational status.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Clinical Neurology
Alexander P. Landry, Kaiyun Yang, Justin Z. Wang, Andrew F. Gao, Gelareh Zadeh
Summary: This study aims to explore the clinical landscape of vestibular schwannoma and identify predictors of outcome to guide surgical decision making. The results showed that syndromic NF2, large tumor size, presence of edema on preoperative MRI, and preoperative trigeminal symptoms were all predictors of postoperative progression/need for further treatment, and were also associated with shorter progression-free survival. Extent of resection, tumor size, and patient age were independently predictive of facial nerve outcome.
JOURNAL OF CLINICAL NEUROSCIENCE
(2022)
Article
Oncology
Kaiyun Yang, Alexander P. Landry, Majid Aljoghaiman, Enrique Gutierrez, Matthias Millesi, Matheuss Leite, Aristotelis Kalyvas, Paola Anna Jablonska, Jaclyn Vialet, Jessica Weiss, Barbara-Ann Millar, Tatianna Conrad, Normand Laperriere, Mark Bernstein, Gelareh Zadeh, David Shultz, Paul N. Kongkham
Summary: Routine postoperative CT scan following resection of brain metastases has low diagnostic yield and does not change patient management in any cases examined in this study.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Article
Clinical Neurology
Aristotelis Kalyvas, Matthias Milesi, Matheus Leite, Kaiyun Yang, Leslie St Jacques, Allan Vescan, Ozgur Mete, Shereen Ezzat, Gelareh Zadeh, Fred Gentili
Summary: The present study showed that SACs can be effectively treated using a simple cyst-opening technique. The routine use of nasoseptal flaps significantly reduced the risk of CSF leakage without compromising nasal quality of life in the long term or mandating additional incisions. Long-term follow-up is important to monitor for late recurrence.
WORLD NEUROSURGERY
(2022)
Article
Pathology
Jian-Qiang Lu, Waleed Jaber B. Al Mohammadi, Crystal Fong, Kaiyun Yang, Jinesa Moodley, John Provias, Snezana Popovic, Ivan Chebib, Aleksa Cenic
Summary: This study examined the clinical, radiological, and pathological features of spinal CAPNON and CSC, finding both similarities and differences between the two. The researchers also proposed a hypothesis that CAPNON may develop in reaction to or as a transitional form of CSC.
Article
Oncology
Kaiyun Yang, Justin Wang, Nisha Kanwar, Anita Villani, Olufemi Ajani, Adam Fleming, Vikas Patil, Yasin Mamatjan, Qingxia Wei, David Malkin, Adam Shlien, Gelareh Zadeh, John Provias
Summary: This is a rare case of DICER1-sarcoma, and the sequencing and methylation information discovered in this case will help further our understanding of this disease.
BRAIN TUMOR PATHOLOGY
(2022)
Article
Neurosciences
Matthias Millesi, Carolyn Lai, Ruth Lau, Vincent Chen Ye, Kaiyun Yang, Matheus Leite, Nilesh Mohan, Ozgur Mete, Shereen Ezzat, Fred Gentili, Gelareh Zadeh, Aristotelis Kalyvas
Summary: The surgical management of Rathke's cleft cysts (RCC) remains controversial, with varying opinions on operative strategy and reconstructive techniques. This study found that simple fenestration (SF) with closed reconstruction is a reasonable approach for most symptomatic RCCs cases, while complete cyst wall resection (CWR) may be reserved for selected cases.
Article
Clinical Neurology
Mohamed M. Salem, Visish M. Srinivasan, Daniel A. Tonetti, Krishnan Ravindran, Philipp Taussky, Kaiyun Yang, Katherine Karahalios, Kunal P. Raygor, Ryan M. Naylor, Joshua S. Catapano, Samon Tavakoli-Sabour, Ahmed Abdelsalam, Stephanie H. Chen, Ramesh Grandhi, Brian T. Jankowitz, Mustafa K. Baskaya, Justin R. Mascitelli, Jamie J. Van Gompel, Jacob Cherian, William T. Couldwell, Louis J. Kim, Aaron A. Cohen-Gadol, Robert M. Starke, Peter Kan, Amir R. Dehdashti, Adib A. Abla, Michael T. Lawton, Jan-Karl Burkhardt
Summary: This study retrospectively analyzed data from 13 North American centers from 2006 to 2021 to evaluate the safety and efficacy of microsurgery for craniocervical junction dural arteriovenous fistulas. The results showed that microsurgery using a far lateral approach provided robust exposure and visualization, allowing for obliteration of the arterialized draining vein close to the fistula point. The approach was associated with a high rate of angiographic cure and favorable clinical outcomes.
Editorial Material
Clinical Neurology
Kaiyun Yang, Kevin Shah, Athos Patsalides, Amir R. Dehdashti
Summary: A 56-year-old woman with a history of an atypical left spheno-caverno-clinoidal meningioma presented with progressive growth of her residual disease within the left cavernous sinus. Surgical resection of the cavernous sinus component of the tumor after revascularization was recommended due to the aggressive nature of atypical meningioma. Postoperative MRI confirmed complete resection of cavernous sinus disease and further treatment options will be considered if there is progression of the residual disease.
OPERATIVE NEUROSURGERY
(2023)
Editorial Material
Clinical Neurology
Kaiyun Yang, Kevin Shah, Athos Patsalides, Denis Knobel, Amir R. Dehdashti
Summary: A 56-year-old woman underwent surgery for resecting a meningioma, leaving residual tumor in the brain and cavernous sinus. The patient received radiotherapy for residual disease but the cavernous sinus disease continued to progress. Surgical resection was planned to control the disease and relieve pressure on the optic chiasm.
OPERATIVE NEUROSURGERY
(2023)
Review
Oncology
Enrique Gutierrez-Valencia, Irving Sanchez, Adrian Valles, Omar Diaz, Tomas F. Gonzalez, Ricardo Balderrama, Jesus Fuentes, Victor Ruiz, Jose Rodriguez, Carlos Saavedra, Lorena Velazquez-Pulido, Eduard Cadavid, Luis E. Ayala-Hernandez, Alejandro Villalvazo, Luis H. Bayardo, Kurl Jamora, Aristotelis Kalyvas, Kaiyun Yang, Barbara-Ann Millar, David B. Shultz
Summary: This study reports the prevalence and prognostic implications of pachymeningeal disease (PMD) in brain metastasis patients, and finds that PMD mainly occurs in patients with well-controlled systemic disease and infratentorial location.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Neurosciences
Justin Turpin, Daniel G. Lynch, Timothy White, Kevin A. Shah, Kaiyun Yang, Jeffrey M. Katz, Amir Dehdashti
Summary: This case series retrospective study reports the outcomes and complications, including the occurrence of hyperperfusion syndrome, in patients who underwent vascular reconstruction surgery. The results suggest that vascular reconstruction is feasible and effective for patients with unequivocal non-moyamoya steno-occlusive disease, and overall favorable outcomes were observed. Although rare, the occurrence of hyperperfusion syndrome should still be considered in the postoperative management of patients.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2023)
Article
Oncology
Kaiyun Yang, Yosef Ellenbogen, Amanda Martyniuk, Michel Sourour, Radwan Takroni, Mohamed Somji, Emily Gardiner, Katrina Hui, Devang Odedra, Ramiro Larrazabal, Almunder Algird, Edward Kachur, Kesava Reddy, Naresh Murty, Forough Farrokhyar, Sheila K. Singh
Summary: This study aimed to investigate whether repeat resection for recurrent glioblastoma (GBM) provides a survival benefit and examine the complication profile. The results showed that repeat surgical resection did not significantly increase overall survival (OS) compared to single surgical resection and may lead to more neurological complications.
NEURO-ONCOLOGY ADVANCES
(2022)
Article
Oncology
Kaiyun Yang, Enrique Gutierrez-Valencia, Alexander P. Landry, Aristotelis Kalyvas, Matthias Millesi, Matheuss Leite, Paola Anna Jablonska, Jessica Weiss, Barbara-Ann Millar, Tatiana Conrad, Normand Laperriere, Mark Bernstein, Gelareh Zadeh, David Shultz, Paul N. Kongkham
Summary: Having multiple metastases does not have a negative impact on outcomes for patients treated with surgery. Surgery should be considered in carefully selected patients, especially those with large tumors, regardless of the total number of metastases.
NEURO-ONCOLOGY ADVANCES
(2022)
