In mouse embryonic fibroblasts, neither caspase-8 nor cellular FLICE-inhibitory protein (FLIP) is necessary for TNF to activate NF-κB, but caspase-8 is required for TNF to cause cell death and induction of FLIP by NF-κB is required to prevent it

Identification of c-FLIPL and c-FLIPS as critical regulators of death receptor-induced apoptosis in pancreatic cancer cells

(2010) C. Haag et al.   GUT

The RING Domain of TRAF2 Plays an Essential Role in the Inhibition of TNFα-Induced Cell Death but Not in the Activation of NF-κB

(2010) Laiqun Zhang et al.   JOURNAL OF MOLECULAR BIOLOGY

TAK1 Is Required for Survival of Mouse Fibroblasts Treated with TRAIL, and Does So by NF-κB Dependent Induction of cFLIPL

(2010) Josep Maria Lluis et al.   PLoS One

Down-regulation of c-FLIP Enhances Death of Cancer Cells by Smac Mimetic Compound

(2009) H. H. Cheung et al.   CANCER RESEARCH

Specific Recognition of Linear Ubiquitin Chains by NEMO Is Important for NF-κB Activation

(2009) Simin Rahighi et al.   CELL

RIPK1 is not essential for TNFR1-induced activation of NF-κB

(2009) W W-L Wong et al.   CELL DEATH AND DIFFERENTIATION

Cellular FLICE-inhibitory protein (c-FLIP) signalling: A key regulator of receptor-mediated apoptosis in physiologic context and in cancer

(2009) Marina Bagnoli et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

TRAF2 Must Bind to Cellular Inhibitors of Apoptosis for Tumor Necrosis Factor (TNF) to Efficiently Activate NF-κB and to Prevent TNF-induced Apoptosis

(2009) James E. Vince et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Shared Principles in NF-κB Signaling

(2008) Matthew S. Hayden et al.   CELL

c-IAP1 and c-IAP2 Are Critical Mediators of Tumor Necrosis Factor α (TNFα)-induced NF-κB Activation

(2008) Eugene Varfolomeev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Triggering of Apoptosis by Puma Is Determined by the Threshold Set by Prosurvival Bcl-2 Family Proteins

(2008) Bernard A. Callus et al.   JOURNAL OF MOLECULAR BIOLOGY

Identification of RIP1 kinase as a specific cellular target of necrostatins

(2008) Alexei Degterev et al.   Nature Chemical Biology

Antigen-mediated T cell expansion regulated by parallel pathways of death

(2008) I. L. Ch'en et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA