RFTS-deleted DNMT1 enhances tumorigenicity with focal hypermethylation and global hypomethylation

Targeted Mutagenesis Results in an Activation of DNA Methyltransferase 1 and Confirms an Autoinhibitory Role of its RFTS Domain

(2014) Pavel Bashtrykov et al.   CHEMBIOCHEM

The UHRF1 Protein Stimulates the Activity and Specificity of the Maintenance DNA Methyltransferase DNMT1 by an Allosteric Mechanism

(2013) Pavel Bashtrykov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The DNA Methyltransferase Dnmt1 Directly Interacts with the SET and RING Finger-associated (SRA) Domain of the Multifunctional Protein Uhrf1 to Facilitate Accession of the Catalytic Center to Hemi-methylated DNA

(2013) Ahmet Can Berkyurek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dissection of cell cycle–dependent dynamics of Dnmt1 by FRAP and diffusion-coupled modeling

(2013) Katrin Schneider et al.   NUCLEIC ACIDS RESEARCH

Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation

(2012) Hideharu Hashimoto et al.   NUCLEIC ACIDS RESEARCH

The Replication Focus Targeting Sequence (RFTS) Domain Is a DNA-competitive Inhibitor of Dnmt1

(2011) Farisa Syeda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss

(2011) Christopher J Klein et al.   NATURE GENETICS

The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1

(2011) Max Felle et al.   NUCLEIC ACIDS RESEARCH

Structural insight into maintenance methylation by mouse DNA methyltransferase 1 (Dnmt1)

(2011) K. Takeshita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aberrant Overexpression of Satellite Repeats in Pancreatic and Other Epithelial Cancers

(2011) D. T. Ting et al.   SCIENCE

UHRF1 is a novel diagnostic marker of lung cancer

(2010) M Unoki et al.   BRITISH JOURNAL OF CANCER

UHRF1-mediated tumor suppressor gene inactivation in nonsmall cell lung cancer

(2010) Alexandros Daskalos et al.   CANCER

hNaa10p contributes to tumorigenesis by facilitating DNMT1-mediated tumor suppressor gene silencing

(2010) Chung-Fan Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

Opposing Roles of Dnmt1 in Early- and Late-Stage Murine Prostate Cancer

(2010) S. R. Morey Kinney et al.   MOLECULAR AND CELLULAR BIOLOGY

Disruption of Dnmt1/PCNA/UHRF1 Interactions Promotes Tumorigenesis from Human and Mice Glial Cells

(2010) Eric Hervouet et al.   PLoS One

Structure of DNMT1-DNA Complex Reveals a Role for Autoinhibition in Maintenance DNA Methylation

(2010) J. Song et al.   SCIENCE

A New Class of Quinoline-Based DNA Hypomethylating Agents Reactivates Tumor Suppressor Genes by Blocking DNA Methyltransferase 1 Activity and Inducing Its Degradation

(2009) J. Datta et al.   CANCER RESEARCH

Dimerization of DNA methyltransferase 1 is mediated by its regulatory domain

(2009) Karin Fellinger et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

DNMT1 Silencing Affects Locus Specific DNA Methylation and Increases Prostate Cancer Derived PC3 Cell Invasiveness

(2009) Ahmed Yaqinuddin et al.   JOURNAL OF UROLOGY

An analytical pipeline for genomic representations used for cytosine methylation studies

(2008) Reid F. Thompson et al.   BIOINFORMATICS

Carcinogen-Induced Gene Promoter Hypermethylation Is Mediated by DNMT1 and Causal for Transformation of Immortalized Bronchial Epithelial Cells

(2008) Leah A. Damiani et al.   CANCER RESEARCH

Silencing of DUOX NADPH Oxidases by Promoter Hypermethylation in Lung Cancer

(2008) S. Luxen et al.   CANCER RESEARCH

High-performance liquid chromatography determination of 5-methyl-2′-deoxycytidine, 2′-deoxycytidine, and other deoxynucleosides and nucleosides in DNA digests

(2007) Armando Alcázar Magaña et al.   ANALYTICAL BIOCHEMISTRY