Structural basis for role of ring finger protein RNF168 RING domain

RNF168 Ubiquitinates K13-15 on H2A/H2AX to Drive DNA Damage Signaling

(2012) Francesca Mattiroli et al.   CELL

TRIP12 and UBR5 Suppress Spreading of Chromatin Ubiquitylation at Damaged Chromosomes

(2012) Thorkell Gudjonsson et al.   CELL

Molecular Insights into the Function of RING Finger (RNF)-containing Proteins hRNF8 and hRNF168 in Ubc13/Mms2-dependent Ubiquitylation

(2012) Stephen J. Campbell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ring Finger Protein RNF169 Antagonizes the Ubiquitin-dependent Signaling Cascade at Sites of DNA Damage

(2012) Jie Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human RNF169 is a negative regulator of the ubiquitin-dependent response to DNA double-strand breaks

(2012) Maria Poulsen et al.   JOURNAL OF CELL BIOLOGY

Tandem Protein Interaction Modules Organize the Ubiquitin-Dependent Response to DNA Double-Strand Breaks

(2012) Stephanie Panier et al.   MOLECULAR CELL

The E3 ligase RNF8 regulates KU80 removal and NHEJ repair

(2012) Lin Feng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications

(2011) S. E. Polo et al.   GENES & DEVELOPMENT

Critical Roles of Ring Finger Protein RNF8 in Replication Stress Responses

(2011) Shirley M.-H. Sy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential regulation of RNF8-mediated Lys48- and Lys63-based poly-ubiquitylation

(2011) Gabriel Tsz-Mei Lok et al.   NUCLEIC ACIDS RESEARCH

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1

(2010) Shinichiro Nakada et al.   NATURE

Ubiquitin signalling in DNA replication and repair

(2010) Helle D. Ulrich et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Genomic instability — an evolving hallmark of cancer

(2010) Simona Negrini et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

RNF168 Binds and Amplifies Ubiquitin Conjugates on Damaged Chromosomes to Allow Accumulation of Repair Proteins

(2009) Carsten Doil et al.   CELL

The RIDDLE Syndrome Protein Mediates a Ubiquitin-Dependent Signaling Cascade at Sites of DNA Damage

(2009) Grant S. Stewart et al.   CELL

RING Finger E3 Ubiquitin Ligases: Structure and Drug Discovery

(2009) Christos Chasapis et al.   CURRENT PHARMACEUTICAL DESIGN

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

E2 interaction and dimerization in the crystal structure of TRAF6

(2009) Qian Yin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Assembly of checkpoint and repair machineries at DNA damage sites

(2009) Michael S.Y. Huen et al.   TRENDS IN BIOCHEMICAL SCIENCES

Noncanonical E2 Variant-Independent Function of UBC13 in Promoting Checkpoint Protein Assembly

(2008) M. S. Y. Huen et al.   MOLECULAR AND CELLULAR BIOLOGY