The ORC/Cdc6/MCM2–7 complex, a new power player for regulated helicase loading

An ORC/Cdc6/MCM2-7 Complex Is Formed in a Multistep Reaction to Serve as a Platform for MCM Double-Hexamer Assembly

(2013) Alejandra Fernández-Cid et al.   MOLECULAR CELL

ATPase-dependent quality control of DNA replication origin licensing

(2013) Jordi Frigola et al.   NATURE

In the absence of ATPase activity, pre-RC formation is blocked prior to MCM2-7 hexamer dimerization

(2013) C. Evrin et al.   NUCLEIC ACIDS RESEARCH

Multiple Cdt1 molecules act at each origin to load replication-competent Mcm2-7 helicases

(2011) Thomas J Takara et al.   EMBO JOURNAL

Eukaryotic Chromosome DNA Replication: Where, When, and How?

(2010) Hisao Masai et al.   Annual Review of Biochemistry

Concerted Loading of Mcm2–7 Double Hexamers around DNA during DNA Replication Origin Licensing

(2009) Dirk Remus et al.   CELL

A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication

(2009) C. Evrin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA