Clamping down on mammalian meiosis

Checkpoint protein Rad9 plays an important role in nucleotide excision repair

(2013) Tiepeng Li et al.   DNA REPAIR

Lagging strand maturation factor Dna2 is a component of the replication checkpoint initiation machinery

(2013) S. Kumar et al.   GENES & DEVELOPMENT

Four pillars of the S-phase checkpoint

(2013) L. Zou   GENES & DEVELOPMENT

The DNA damage checkpoint protein RAD9A is essential for male meiosis in the mouse

(2013) A. Vasileva et al.   JOURNAL OF CELL SCIENCE

The Mre11-Rad50-Nbs1 (MRN) complex has a specific role in the activation of Chk1 in response to stalled replication forks

(2013) Joon Lee et al.   MOLECULAR BIOLOGY OF THE CELL

A Role for the MRN Complex in ATR Activation via TOPBP1 Recruitment

(2013) Anja M. Duursma et al.   MOLECULAR CELL

Two Distinct Modes of ATR Activation Orchestrated by Rad17 and Nbs1

(2013) Bunsyo Shiotani et al.   Cell Reports

Conditional Inactivation of the DNA Damage Response Gene Hus1 in Mouse Testis Reveals Separable Roles for Components of the RAD9-RAD1-HUS1 Complex in Meiotic Chromosome Maintenance

(2013) Amy M. Lyndaker et al.   PLoS Genetics

Meiotic DNA double-strand breaks and chromosome asynapsis in mice are monitored by distinct HORMAD2-independent and -dependent mechanisms

(2012) L. Wojtasz et al.   GENES & DEVELOPMENT

HORMAD1-dependent checkpoint/surveillance mechanism eliminates asynaptic oocytes

(2012) Hiroshi Kogo et al.   GENES TO CELLS

Disease severity in a mouse model of ataxia telangiectasia is modulated by the DNA damage checkpoint gene Hus1

(2012) Gabriel Balmus et al.   HUMAN MOLECULAR GENETICS

Rad9B responds to nucleolar stress through ATR and JNK signalling, and delays the G1-S transition

(2012) A. J. Perez-Castro et al.   JOURNAL OF CELL SCIENCE

Noncanonical Role of the 9-1-1 Clamp in the Error-Free DNA Damage Tolerance Pathway

(2012) Georgios Ioannis Karras et al.   MOLECULAR CELL

TopBP1 and DNA polymerase alpha-mediated recruitment of the 9-1-1 complex to stalled replication forks: Implications for a replication restart-based mechanism for ATR checkpoint activation

(2011) Shan Yan et al.   CELL CYCLE

Loading of Meiotic Cohesin by SCC-2 Is Required for Early Processing of DSBs and for the DNA Damage Checkpoint

(2011) James Lightfoot et al.   CURRENT BIOLOGY

Contributions of Rad9 to tumorigenesis

(2011) Constantinos G. Broustas et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

A DNA Damage Response Screen Identifies RHINO, a 9-1-1 and TopBP1 Interacting Protein Required for ATR Signaling

(2011) C. Cotta-Ramusino et al.   SCIENCE

Checkpoint mechanisms: the puppet masters of meiotic prophase

(2011) Amy J. MacQueen et al.   TRENDS IN CELL BIOLOGY

Meiotic Errors Activate Checkpoints that Improve Gamete Quality without Triggering Apoptosis in Male Germ Cells

(2010) Aimee Jaramillo-Lambert et al.   CURRENT BIOLOGY

Evidence that Meiotic Sex Chromosome Inactivation Is Essential for Male Fertility

(2010) Hélène Royo et al.   CURRENT BIOLOGY

Mouse Rad9b is essential for embryonic development and promotes resistance to DNA damage

(2010) Corinne Leloup et al.   DEVELOPMENTAL DYNAMICS

Interaction between human mismatch repair recognition proteins and checkpoint sensor Rad9-Rad1-Hus1

(2010) Haibo Bai et al.   DNA REPAIR

Rad9 Is Required for B Cell Proliferation and Immunoglobulin Class Switch Recombination

(2010) Lili An et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammalian BLM helicase is critical for integrating multiple pathways of meiotic recombination

(2010) J. Kim Holloway et al.   JOURNAL OF CELL BIOLOGY

Mouse Rad1 deletion enhances susceptibility for skin tumor development

(2010) Lu Han et al.   Molecular Cancer

ATRIP from TopBP1 to ATR--in vitro activation of a DNA damage checkpoint

(2010) Y.-j. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synaptonemal complex formation and meiotic checkpoint signaling are linked to the lateral element protein Red1

(2010) C. S. Eichinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hormad1 Mutation Disrupts Synaptonemal Complex Formation, Recombination, and Chromosome Segregation in Mammalian Meiosis

(2010) Yong-Hyun Shin et al.   PLoS Genetics

Repair activities of human 8-oxoguanine DNA glycosylase are stimulated by the interaction with human checkpoint sensor Rad9–Rad1–Hus1 complex

(2009) Min Ju Park et al.   DNA REPAIR

DNA double-strand breaks in meiosis: Checking their formation, processing and repair

(2009) Maria Pia Longhese et al.   DNA REPAIR

A tale of two tails: Activation of DNA damage checkpoint kinase Mec1/ATR by the 9-1-1 clamp and by Dpb11/TopBP1

(2009) Vasundhara M. Navadgi-Patil et al.   DNA REPAIR

DNA polymerase β is critical for mouse meiotic synapsis

(2009) Dawit Kidane et al.   EMBO JOURNAL

Structure and Functional Implications of the Human Rad9-Hus1-Rad1 Cell Cycle Checkpoint Complex

(2009) Min Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TopBP1 and DNA polymerase-α directly recruit the 9-1-1 complex to stalled DNA replication forks

(2009) Shan Yan et al.   JOURNAL OF CELL BIOLOGY

Crystal Structure of the Human Rad9–Hus1–Rad1 Clamp

(2009) Sun Young Sohn et al.   JOURNAL OF MOLECULAR BIOLOGY

The Drosophila hus1 gene is required for homologous recombination repair during meiosis

(2009) Gabriella Peretz et al.   MECHANISMS OF DEVELOPMENT

Crystal Structure of the Rad9-Rad1-Hus1 DNA Damage Checkpoint Complex—Implications for Clamp Loading and Regulation

(2009) Andrew S. Doré et al.   MOLECULAR CELL

Mutation of the Mouse Syce1 Gene Disrupts Synapsis and Suggests a Link between Synaptonemal Complex Structural Components and DNA Repair

(2009) Ewelina Bolcun-Filas et al.   PLoS Genetics

Targeted Deletion of Rad9 in Mouse Skin Keratinocytes Enhances Genotoxin-Induced Tumor Development

(2008) Z. Hu et al.   CANCER RESEARCH

Cre recombinase activity specific to postnatal, premeiotic male germ cells in transgenic mice

(2008) Patricia I. Sadate-Ngatchou et al.   GENESIS

Progression of meiotic recombination requires structural maturation of the central element of the synaptonemal complex

(2008) G. Hamer et al.   JOURNAL OF CELL SCIENCE

The 9-1-1 DNA Clamp Is Required for Immunoglobulin Gene Conversion

(2008) A. Saberi et al.   MOLECULAR AND CELLULAR BIOLOGY

Mus81/Mms4 Endonuclease and Sgs1 Helicase Collaborate to Ensure Proper Recombination Intermediate Metabolism during Meiosis

(2008) Lea Jessop et al.   MOLECULAR CELL

Rad9 plays an important role in DNA mismatch repair through physical interaction with MLH1

(2008) W. He et al.   NUCLEIC ACIDS RESEARCH

 -H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin

(2008) A. Kinner et al.   NUCLEIC ACIDS RESEARCH

Disruption of pairing and synapsis of chromosomes causes stage-specific apoptosis of male meiotic cells

(2007) G. Hamer et al.   THERIOGENOLOGY