Journal
CELL CYCLE
Volume 11, Issue 19, Pages 3666-3678Publisher
LANDES BIOSCIENCE
DOI: 10.4161/cc.21927
Keywords
centrosome; centriole assembly; Mps1; kinase; VDAC
Categories
Funding
- National Institutes of Health [GM77311]
- Ohio Cancer Research Associates seed grant
- Ohio State University Comprehensive Cancer Center
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Centrioles are duplicated during S-phase to generate the two centrosomes that serve as mitotic spindle poles during mitosis. The centrosomal pool of the Mps1 kinase is important for centriole assembly, but how Mps1 is delivered to centrosomes is unknown. Here we have identified a centrosome localization domain within Mps1 and identified the mitochondrial porin VDAC3 as a protein that binds to this region of Mps1. Moreover, we show that VDAC3 is present at the mother centriole and modulates centriole assembly by recruiting Mps1 to centrosomes.
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