MEK2 regulates ribonucleotide reductase activity through functional interaction with ribonucleotide reductase small subunit p53R2

Dominant roles of the Raf/MEK/ERK pathway in cell cycle progression, prevention of apoptosis and sensitivity to chemotherapeutic drugs

(2011) Linda S. Steelman et al.   CELL CYCLE

ATM-dependent ERK signaling via AKT in response to DNA double-strand breaks

(2011) Ashraf Khalil et al.   CELL CYCLE

Involvement of Akt and mTOR in chemotherapeutic- and hormonal-based drug resistance and response to radiation in breast cancer cells

(2011) Linda S. Steelman et al.   CELL CYCLE

The Raf/MEK/ERK pathway can govern drug resistance, apoptosis and sensitivity to targeted therapy

(2010) Stephen L. Abrams et al.   CELL CYCLE

Implication of Checkpoint Kinase-dependent Up-regulation of Ribonucleotide Reductase R2 in DNA Damage Response

(2009) Yong-Wei Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ribonucleotide reductase small subunit p53R2 suppresses MEK–ERK activity by binding to ERK kinase 2

(2009) C Piao et al.   ONCOGENE

Essential role of Chk1 in S phase progression through regulation of RNR2 expression

(2008) Hiromichi Naruyama et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

 -Irradiation-Induced DNA Damage Checkpoint Activation Involves Feedback Regulation between Extracellular Signal-Regulated Kinase 1/2 and BRCA1

(2008) Y. Yan et al.   CANCER RESEARCH

Dif1 Is a DNA-Damage-Regulated Facilitator of Nuclear Import for Ribonucleotide Reductase

(2008) Yang David Lee et al.   MOLECULAR CELL

ATM-mediated serine 72 phosphorylation stabilizes ribonucleotide reductase small subunit p53R2 protein against MDM2 to DNA damage

(2008) L. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA