BRCA1-directed, enhanced and aberrant homologous recombination

BRCA1 A-Complex fine tunes repair functions of BRCA1

(2016) Janelle L Harris et al.   Aging-US

Mutations in the BRCT binding site of BRCA1 result in hyper-recombination

(2016) Seth M. Dever et al.   Aging-US

Homologous recombination repair is essential for repair of vosaroxin-induced DNA double-strand breaks

(2015)   Oncotarget

AKT1/BRCA1 in the control of homologous recombination and genetic stability: the missing link between hereditary and sporadic breast cancers

(2015)   Oncotarget

p53-Dependent BRCA1 Nuclear Export Controls Cellular Susceptibility to DNA Damage

(2011) J. Jiang et al.   CANCER RESEARCH

BRCT domains

(2011) Charles Chung Yun Leung et al.   CELL CYCLE

Synthetic lethality of PARP inhibition in cancers lackingBRCA1andBRCA2mutations

(2011) Konstantin J. Dedes et al.   CELL CYCLE

BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair

(2011) A. V. Nimonkar et al.   GENES & DEVELOPMENT

RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear foci

(2011) Y. Hu et al.   GENES & DEVELOPMENT

The BRCA1-RAP80 Complex Regulates DNA Repair Mechanism Utilization by Restricting End Resection

(2011) Kara A. Coleman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure–Activity Relationship Studies To Probe the Phosphoprotein Binding Site on the Carboxy Terminal Domains of the Breast Cancer Susceptibility Gene 1

(2011) Ziyan Yuan et al.   JOURNAL OF MEDICINAL CHEMISTRY

BRCA1 tumour suppression occurs via heterochromatin-mediated silencing

(2011) Quan Zhu et al.   NATURE

Functional Connection between Rad51 and PML in Homology-Directed Repair

(2011) Sergei Boichuk et al.   PLoS One

BRCA1, Everything But the RING?

(2011) R. A. Greenberg   SCIENCE

BRCA1 Tumor Suppression Depends on BRCT Phosphoprotein Binding, But Not Its E3 Ligase Activity

(2011) R. Shakya et al.   SCIENCE

SUMO playing tag with ubiquitin

(2011) Gerrit J.K. Praefcke et al.   TRENDS IN BIOCHEMICAL SCIENCES

Exploiting the P-1 Pocket of BRCT Domains Toward a Structure Guided Inhibitor Design

(2011) Ziyan Yuan et al.   ACS Medicinal Chemistry Letters

Targeted next-generation sequencing for routine clinical screening of mutations

(2011) Jamie MJ Weaver et al.   Genome Medicine

Fine tuning chemotherapy to match BRCA1 status

(2010) Melissa Price et al.   BIOCHEMICAL PHARMACOLOGY

The RING heterodimer BRCA1–BARD1 is a ubiquitin ligase inactivated by the platinum-based anticancer drugs

(2010) Apichart Atipairin et al.   BREAST CANCER RESEARCH AND TREATMENT

Comprehensive Analysis of Missense Variations in the BRCT Domain of BRCA1 by Structural and Functional Assays

(2010) Megan S. Lee et al.   CANCER RESEARCH

BRCA1 regulation of base excision repair pathway

(2010) Tapas Saha et al.   CELL CYCLE

Identification of Filamin A as a BRCA1-interacting protein required for efficient DNA repair

(2010) Aneliya Velkova et al.   CELL CYCLE

Cisplatin Affects the Conformation of Apo Form, not Holo Form, of BRCA1 RING Finger Domain and Confers Thermal Stability

(2010) Apichart Atipairin et al.   CHEMISTRY & BIODIVERSITY

Toward Classification of BRCA1 Missense Variants Using a Biophysical Approach

(2010) Pamela J. E. Rowling et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Magic bullets in nature's arsenal

(2010) Joshua A Kritzer   Nature Chemical Biology

Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis

(2010) Mary Ellen Moynahan et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PALB2 Links BRCA1 and BRCA2 in the DNA-Damage Response

(2009) Feng Zhang et al.   CURRENT BIOLOGY

MRG15 Is a Novel PALB2-interacting Factor Involved in Homologous Recombination

(2009) Shirley M.-H. Sy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ubiquitin landscape at DNA double-strand breaks

(2009) Troy E. Messick et al.   JOURNAL OF CELL BIOLOGY

The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress

(2009) Joanna R. Morris et al.   NATURE

Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks

(2009) Yaron Galanty et al.   NATURE

BRCA1 and its toolbox for the maintenance of genome integrity

(2009) Michael S.Y. Huen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inhibition of Poly(ADP-Ribose) Polymerase in Tumors fromBRCAMutation Carriers

(2009) Peter C. Fong et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Rap80-BRCC36 de-ubiquitinating enzyme complex antagonizes RNF8-Ubc13-dependent ubiquitination events at DNA double strand breaks

(2009) G. Shao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PALB2 is an integral component of the BRCA complex required for homologous recombination repair

(2009) S. M. H. Sy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Linking the Cellular Functions of BRCA Genes to Cancer Pathogenesis and Treatment

(2008) Ashok R. Venkitaraman   Annual Review of Pathology-Mechanisms of Disease

“BRCAness” Syndrome in Ovarian Cancer: A Case-Control Study Describing the Clinical Features and Outcome of Patients With Epithelial Ovarian Cancer Associated WithBRCA1andBRCA2Mutations

(2008) David S.P. Tan et al.   JOURNAL OF CLINICAL ONCOLOGY

Thiolate Bridging and Metal Exchange in Adducts of a Zinc Finger Model and PtIIComplexes: Biomimetic Studies of Protein/Pt/DNA Interactions

(2008) Elky Almaraz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

E3 ligase activity of BRCA1 is not essential for mammalian cell viability or homology-directed repair of double-strand DNA breaks

(2008) L. J. Reid et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual-fluorophore quantitative high-throughput screen for inhibitors of BRCT–phosphoprotein interaction

(2007) Anton Simeonov et al.   ANALYTICAL BIOCHEMISTRY