Epigenetic silencing of Notch signaling in gastrointestinal cancers

Epigenetic regulation of Delta-Like1 controls Notch1 activation in gastric cancer

(2015) Giulia Piazzi et al.   Oncotarget

Fine-tuning of the intracellular canonical Notch signaling pathway

(2012) Tilman Borggrefe et al.   CELL CYCLE

Notch1 counteracts WNT/β-catenin signaling through chromatin modification in colorectal cancer

(2012) Hyun-A Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells

(2011) K. L. VanDussen et al.   DEVELOPMENT

Dll1- and Dll4-Mediated Notch Signaling Are Required for Homeostasis of Intestinal Stem Cells

(2011) Luca Pellegrinet et al.   GASTROENTEROLOGY

Complex interplay between  -catenin signalling and Notch effectors in intestinal tumorigenesis

(2011) G. Peignon et al.   GUT

E-cadherin impairment increases cell survival through Notch-dependent upregulation of Bcl-2

(2011) António Carlos Ferreira et al.   HUMAN MOLECULAR GENETICS

Genetic Evidence That Intestinal Notch Functions Vary Regionally and Operate through a Common Mechanism of Math1 Repression

(2011) Tae-Hee Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oncogenic and tumor suppressor functions of Notch in cancer: it’s NOTCH what you think: Table I.

(2011) Camille Lobry et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cell Lineage metastability in Gfi1-deficient mouse intestinal epithelium

(2010) Matthew Bjerknes et al.   DEVELOPMENTAL BIOLOGY

Mouse atonal homolog 1 directs intestinal progenitors to secretory cell rather than absorptive cell fate

(2010) Kelli L. VanDussen et al.   DEVELOPMENTAL BIOLOGY

Atonal Homolog 1 Is Required for Growth and Differentiation Effects of Notch/γ-Secretase Inhibitors on Normal and Cancerous Intestinal Epithelial Cells

(2010) Avedis Kazanjian et al.   GASTROENTEROLOGY

Loss of enteroendocrine cells in mice alters lipid absorption and glucose homeostasis and impairs postnatal survival

(2010) Georg Mellitzer et al.   JOURNAL OF CLINICAL INVESTIGATION

Intestinal stem cells lacking the Math1 tumour suppressor are refractory to Notch inhibitors

(2010) Johan H. van Es et al.   Nature Communications

Cross-talk between miRNA and Notch signaling pathways in tumor development and progression

(2009) Zhiwei Wang et al.   CANCER LETTERS

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

SAM pointed domain ETS factor (SPDEF) regulates terminal differentiation and maturation of intestinal goblet cells

(2009) Taeko K. Noah et al.   EXPERIMENTAL CELL RESEARCH

Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine

(2009) S. Fre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteasomal degradation of Atoh1 by aberrant Wnt signaling maintains the undifferentiated state of colon cancer

(2008) Mikayo Aragaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS