Article
Oncology
Dakui Luo, Hao Fan, Xiang Ma, Chao Yang, Yu He, Yugang Ge, Mingkun Jiang, Zekuan Xu, Li Yang
Summary: Existing evidence strongly suggests that miR-1301-3p plays a significant role in the tumorigenesis and progression of gastric cancer. The overexpression of miR-1301-3p in GC tissues and cells accelerates cell proliferation, cell cycle progression, and tumorigenesis. SIRT1 is identified as a direct target of miR-1301-3p, and knockdown of SIRT1 enhances the proliferative ability of GC cells.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Qixin Shi, Shaohua Li, Qiang Lyu, Shuai Zhang, Yungang Bai, Jin Ma
Summary: Hypoxia impairs the structure and function of the blood-brain barrier (BBB), leading to pathophysiological changes in stroke and high-altitude brain edema. Brain microvascular endothelial cells (BMECs) are important elements of the BBB, but their role in hypoxia is still unknown. This study found that hypoxia inhibits BMEC cell cycle progression and proliferation, and downregulates the expression of minichromosome maintenance complex component 2 (Mcm2). Overexpression of Mcm2 attenuates the inhibitory effects of hypoxia on cell cycle progression and proliferation. The miRNA miR-212-3p is identified as an important regulator of Mcm2 in hypoxia, and its inhibition can rescue the effects of hypoxia on BMECs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Kaiyi Tao, JinShi Liu, JinXiao Liang, XiaoFang Xu, LiWei Xu, WeiMin Mao
Summary: The study investigated the molecular mechanism of lung adenocarcinoma (LUAD) progression and the communication between cancer cells and vascular endothelial cells. The findings demonstrated that miR-30a-5p could be delivered from vascular endothelial cells to LUAD cells via exosomes to inhibit tumor progression.
Article
Cell Biology
Maria Victoria Castro, Gaston Alexis Barbero, Maria Belen Villanueva, Luca Grumolato, Jeremie Nsengimana, Julia Newton-Bishop, Edith Illescas, Maria Josefina Quezada, Pablo Lopez-Bergami
Summary: Contrary to previous findings, the study reveals that ROR2 acts as a tumor suppressor in melanoma by inhibiting cell-cycle progression and melanoma cell proliferation. This effect is mediated through inhibition of Akt phosphorylation and subsequent regulation of key cell-cycle regulators, leading to reduced tumor growth both in vitro and in vivo. The expression of ROR2 is associated with favorable clinical outcomes in melanoma patients, indicating its potential as a prognostic marker.
JOURNAL OF BIOMEDICAL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Magdalena Misiura, Tomasz Guszczyn, Ilona Oscilowska, Weronika Baszanowska, Jerzy Palka, Wojciech Miltyk
Summary: PRP activates a complex of growth factors and adhesion receptors that stimulate cell proliferation, migration, and collagen biosynthesis, with PEPD playing a key role in EGFR-dependent keratinocyte proliferation. This study provides a novel mechanism for PRP-dependent wound healing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Mengxue Jiang, Zhijian Kuang, Yaohui He, Yin Cao, Tingyan Yu, Jidong Cheng, Wen Liu, Wei Wang
Summary: This study reveals that SNAPIN plays a crucial role in regulating insulin secretion and beta cell proliferation, with its expression influenced by age and diabetes. The function of SNAPIN is achieved through its impact on cell cycle regulation, suggesting it might be a potential pharmacotherapeutic target for diabetes mellitus.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Oncology
Qi Li, Mo Yan, Chunhui Wang, Kaibin Wang, Guochang Bao
Summary: CKAP2L is overexpressed in prostate cancer and is associated with higher Gleason grade and poor clinical outcomes. Silencing CKAP2L inhibits cell proliferation, impairs monolayer formation, and inhibits cell invasion. CKAP2L is a direct target of miR-326, which has a carcinostatic effect by binding to the 3' untranslated regions (3'UTRs) of CKAP2L mRNA. Deletion of CKAP2L reduces the expression of genes involved in the mitotic cell cycle and chromosome segregation.
Article
Medicine, Research & Experimental
Lei Wang, Yan Liu, Zhengtao Yu, Jianwu Gong, Zhiyong Deng, Nianjun Ren, Zhe Zhong, Hao Cai, Zhi Tang, Haofeng Cheng, Shuai Chen, Zhengwen He
Summary: The study investigates the pathogenesis and potential molecular markers of glioma by examining the differential expression of miRNA and mRNA. Several miRNAs and mRNAs were identified as having significant impact on glioma cell behavior, with miR-139-5p/GABRA1 axis suggested as a novel therapeutic target.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Yingji Chen, Ying Ji, Suo Liu, Yicai Liu, Wei Feng, Longyu Jin
Summary: PTBP3 is overexpressed in LUSC tissues and its high expression is significantly correlated with poor prognosis. PTBP3 knockdown results in decreased cell proliferation rate. Bioinformatics analysis reveals that PTBP3 is involved in cell cycle regulation in LUSC.
CANCER CELL INTERNATIONAL
(2022)
Article
Anatomy & Morphology
Shan Gong, Bo Bai, Guangyu Sun, Haihong Jin, Zhengmao Zhang
Summary: This study found that CDCA3 was up-regulated in ovarian cancer and knockdown of CDCA3 could inhibit proliferation and migration, enhance sensitivity to cisplatin, and induce apoptosis in ovarian cancer cells. In vivo experiments further confirmed the inhibitory effect of CDCA3 knockdown on tumor growth.
Article
Oncology
Fan Yang, Zhanwen Sun, Dengyun Wang, Tian Du
Summary: The study reveals that miR-106b-5p enhances proliferation, colony formation, adhesion, migration, and invasion, and induces cell cycle progression, while repressing apoptosis in esophageal squamous cell carcinoma (ESCC) by targeting HPGD. This finding suggests that the miR-106b-5p/HPGD axis may serve as a promising target for the diagnosis and treatment of ESCC.
Article
Medicine, Research & Experimental
Zhihua Teng, Jie Yao, Ling Zhu, Lufeng Zhao, Gang Chen
Summary: This study revealed that ZNF655 is abundantly expressed in NSCLC, and its knockdown can inhibit the malignant behaviors of tumor cells, leading to decreased tumorigenesis. ZNF655 may regulate apoptosis of NSCLC cells through the PI3K/Akt and p53 signaling pathways.
Article
Cell Biology
Changhui Li, Jiaqi Zhang, Xiaohua Yang, Cheng Hu, Tianqing Chu, Runbo Zhong, Yinchen Shen, Fang Hu, Feng Pan, Jianlin Xu, Jun Lu, Xiaoxuan Zheng, Hai Zhang, Wei Nie, Baohui Han, Xueyan Zhang
Summary: The study has demonstrated the significant role of hsa_circ_0003222 in NSCLC progression and resistance, with its high expression associated with disease stage, metastasis, and patient survival rate. Silencing hsa_circ_0003222 led to reduced stemness-like properties and chemoresistance in tumor cells.
CELL DEATH & DISEASE
(2021)
Article
Environmental Sciences
Ping Deng, Miduo Tan, Wei Zhou, Chunhai Chen, Yu Xi, Peng Gao, Qinlong Ma, Yidan Liang, Mengyan Chen, Li Tian, Jia Xie, Mengyu Liu, Yan Luo, Yanqi Li, Lei Zhang, Liting Wang, Youlong Zeng, Huifeng Pi, Zhengping Yu, Zhou Zhou
Summary: The study found that BPA exposure significantly promoted the proliferation and migration of MCF-7 cells by affecting the cell cycle pathway. Screening differentially expressed genes identified PTTG1 and CDC20 as key targets associated with BPA-induced cell proliferation and migration.
Article
Biochemistry & Molecular Biology
Bo-Quan Shan, Wen Li, Hui He, He-Yan Zhao, Mei-Ling Tian, Xiang Cheng, Jian-Bing Qin, Guo-Hua Jin
Summary: The study demonstrated that miR-33-3p inhibited proliferation and promoted differentiation of PC12 cells into neuron-like cells, with Slc29a1 being the target gene. This suggests that targeting the miR-33-3p/Slc29a1 axis could be a promising therapeutic approach for neurological diseases characterized by neuron degeneration.
NEUROCHEMICAL RESEARCH
(2021)
