Bioenergy sensing in the brain

Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1α in skeletal muscle

(2016) Orsolya M. Palacios et al.   Aging-US

Multiple Defects in Energy Metabolism in Alzheimers Disease

(2012) I. L. Ferreira et al.   CURRENT DRUG TARGETS

Neuronal cell death in neonatal hypoxia-ischemia

(2011) Frances J. Northington et al.   ANNALS OF NEUROLOGY

AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid β-peptide exposure

(2011) Claire Thornton et al.   BIOCHEMICAL JOURNAL

Metformin extends life span of HER-2/neu transgenic mice and in combination with melatonin inhibits growth of transplantable tumors in vivo

(2011) Vladimir N. Anisimov et al.   CELL CYCLE

Calorie restriction: Decelerating mTOR-driven aging from cells to organisms (including humans)

(2011) Mikhail V Blagosklonny   CELL CYCLE

Antagonistic control of muscle cell size by AMPK and mTORC1

(2011) Rémi Mounier et al.   CELL CYCLE

Nuclear translocation of AMPK-α1 potentiates striatal neurodegeneration in Huntington’s disease

(2011) Tz-Chuen Ju et al.   JOURNAL OF CELL BIOLOGY

AMP-activated protein kinase: a potential player in Alzheimer’s disease

(2011) Antero Salminen et al.   JOURNAL OF NEUROCHEMISTRY

Structure of mammalian AMPK and its regulation by ADP

(2011) Bing Xiao et al.   NATURE

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

AMP-activated protein kinase (AMPK) activity is not required for neuronal development but regulates axogenesis during metabolic stress

(2011) T. Williams et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AMP-Activated Protein Kinase Regulates Neuronal Polarization by Interfering with PI 3-Kinase Localization

(2011) S. Amato et al.   SCIENCE

Involvement of AMP-activated-protein-kinase (AMPK) in neuronal amyloidogenesis

(2010) Je-Seong Won et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Axonal morphometry of hippocampal pyramidal neurons semi-automatically reconstructed after in vivo labeling in different CA3 locations

(2010) Deepak Ropireddy et al.   Brain Structure & Function

Genome-wide inhibitory impact of the AMPK activator metformin on [kinesins, tubulins, histones, aurorasandpolo-like kinases] M-phase cell cycle genes in human breast cancer cells

(2010) Cristina Oliveras-Ferraros et al.   CELL CYCLE

Rapamycin and quasi-programmed aging: Four years later

(2010) Mikhail V Blagosklonny   CELL CYCLE

Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and amyloid-β peptide degradation

(2010) Valérie Vingtdeux et al.   FASEB JOURNAL

AMPK β subunits display isoform specific affinities for carbohydrates

(2010) Ann Koay et al.   FEBS LETTERS

AMP-activated Protein Kinase Signaling Activation by Resveratrol Modulates Amyloid-β Peptide Metabolism

(2010) Valérie Vingtdeux et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMP-activated protein kinase mediates activity-dependent regulation of peroxisome proliferator-activated receptor γ coactivator-1α and nuclear respiratory factor 1 expression in rat visual cortical neurons

(2010) L. Yu et al.   NEUROSCIENCE

Metabolic Regulation of Neuronal Plasticity by the Energy Sensor AMPK

(2010) Wyatt B. Potter et al.   PLoS One

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

AMP-activated protein kinase is activated in Parkinson’s disease models mediated by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

(2009) Jae-Sun Choi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of neuron mitochondrial biogenesis and relevance to brain health

(2009) Isaac G. Onyango et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

AMP-activated protein kinase confers protection against TNF-α-induced cardiac cell death

(2009) Girish Kewalramani et al.   CARDIOVASCULAR RESEARCH

AMP-Activated Protein Kinase Phosphorylates Retinoblastoma Protein to Control Mammalian Brain Development

(2009) Biplab Dasgupta et al.   DEVELOPMENTAL CELL

PGC-1α and PGC-1β Regulate Mitochondrial Density in Neurons

(2009) Przemyslaw Wareski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMP-activated Protein Kinase Is Involved in Neural Stem Cell Growth Suppression and Cell Cycle Arrest by 5-Aminoimidazole-4-carboxamide-1-β-d-ribofuranoside and Glucose Deprivation by Down-regulating Phospho-retinoblastoma Protein and Cyclin D

(2009) Yi Zang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMPK as a mediator of hormonal signalling

(2009) Chung Thong Lim et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

AMPK in the brain: its roles in energy balance and neuroprotection

(2009) Gabriele V. Ronnett et al.   JOURNAL OF NEUROCHEMISTRY

Coupling of Energy Metabolism and Synaptic Transmission at the Transcriptional Level: Role of Nuclear Respiratory Factor 1 in Regulating both Cytochrome c Oxidase and NMDA Glutamate Receptor Subunit Genes

(2009) S. S. Dhar et al.   JOURNAL OF NEUROSCIENCE

Regulation of Glucose Transporter 3 Surface Expression by the AMP-Activated Protein Kinase Mediates Tolerance to Glutamate Excitation in Neurons

(2009) P. Weisova et al.   JOURNAL OF NEUROSCIENCE

Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription

(2009) Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tau phosphorylation: the therapeutic challenge for neurodegenerative disease

(2009) Diane P. Hanger et al.   TRENDS IN MOLECULAR MEDICINE

Drosophila alicorn Is a Neuronal Maintenance Factor Protecting against Activity-Induced Retinal Degeneration

(2008) M. R. Spasic et al.   JOURNAL OF NEUROSCIENCE

Caenorhabditis elegans dauers need LKB1/AMPK to ration lipid reserves and ensure long-term survival

(2008) Patrick Narbonne et al.   NATURE

Role of hypothalamic AMP-kinase in food intake regulation

(2008) Yasuhiko Minokoshi et al.   NUTRITION