A new in vitro system for activating the cell cycle checkpoint

Reconstitution of RPA-covered single-stranded DNA-activated ATR-Chk1 signaling

(2010) J.-H. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Studying the DNA damage response using in vitro model systems

(2009) Elizabeth Garner et al.   DNA REPAIR

Common mechanisms of PIKK regulation

(2009) Courtney A. Lovejoy et al.   DNA REPAIR

The human ATR-mediated DNA damage checkpoint in a reconstituted system

(2009) Jun-Hyuk Choi et al.   METHODS

The F Box Protein Fbx6 Regulates Chk1 Stability and Cellular Sensitivity to Replication Stress

(2009) You-Wei Zhang et al.   MOLECULAR CELL

Single-Stranded DNA Orchestrates an ATM-to-ATR Switch at DNA Breaks

(2009) Bunsyo Shiotani et al.   MOLECULAR CELL

Cooperative activation of the ATR checkpoint kinase by TopBP1 and damaged DNA

(2009) J.-H. Choi et al.   NUCLEIC ACIDS RESEARCH

Chk1 C-terminal regulatory phosphorylation mediates checkpoint activation by de-repression of Chk1 catalytic activity

(2009) M Walker et al.   ONCOGENE

Breaching the DNA damage checkpoint via PF-00477736, a novel small-molecule inhibitor of checkpoint kinase 1

(2008) A. Blasina et al.   MOLECULAR CANCER THERAPEUTICS

Essential function of Chk1 can be uncoupled from DNA damage checkpoint and replication control

(2008) D. Wilsker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA