Article
Chemistry, Multidisciplinary
Wen-liang Wang, Zong-ru Jiang, Chen Hu, Cheng Chen, Zhen-quan Hu, Ao-li Wang, Li Wang, Jing Liu, Wen-chao Wang, Qing-song Liu
Summary: Inhibition of PGK1 kinase activity may be a potential strategy for glioma treatment, as demonstrated by NG52 reversing the Warburg effect and switching cellular glucose metabolism mode.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Cell Biology
Pan Wang, Sheng Gong, Jinyu Pan, Junwei Wang, Dewei Zou, Shuanglong Xiong, Lu Zhao, Qian Yan, Yangming Deng, Nan Wu, Bin Liao
Summary: Combining hyperbaric oxygen and chemotherapy enhances chemotherapy sensitivity in GBM cells by decreasing the expression of HIF1 alpha, HIF2 alpha, and Sox2, thus promoting cell proliferation and chemosensitization.
CELL DEATH DISCOVERY
(2021)
Review
Oncology
Nikolaus von Knebel Doeberitz, Daniel Paech, Dominik Sturm, Stefan Pusch, Sevin Turcan, Yogen Saunthararajah
Summary: Glioma cells often have mutated or deleted p53 and/or p16/CDKN2A, affecting the effectiveness of apoptosis-based treatments. However, the master transcription factors in glioma cells, which are responsible for specifying and driving glial lineage fates, still remain active. Disrupted epigenetic regulation and amplified repressing mechanisms contribute to malignant self-replication in gliomas. Inhibiting the repressive epigenetic enzymes can activate late-glial genes and stop the self-replication process, providing potential targets for noncytotoxic therapy.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Multidisciplinary Sciences
Hong -Wei An, Da -Yong Hou, Jia Yang, Zi-Qi Wang, Man -Di Wang, Rui Zheng, Ni-Yuan Zhang, Xing-Jie Hu, Zhi-Jia Wang, Lu Wang, Di Liu, Jun-Feng Hao, Wanhai Xu, Yuliang Zhao, Hao Wang
Summary: Alpha-interferon was found to reduce the bladder cancer recurrence rate to 22%. In comparison, the recurrence rates were 89% and 78% for doxycycline and BCG treatment, respectively, which are currently used in clinic. Mechanistic studies showed that bsGP enhances the infiltration of CD8+ T cells into tumor cells by reducing the matrix microenvironment barrier.
Article
Physics, Particles & Fields
Wan-Xia Li, Xiao-Ming Xu, H. J. Weber
Summary: We study various processes involving meson-meson scattering and meson production in different collision scenarios, deriving transition amplitudes from transition potential and wave functions to understand the underlying mechanisms of meson generation.
EUROPEAN PHYSICAL JOURNAL C
(2021)
Article
Cell Biology
Mariana de S. Santos, Virginia T. M. Lima, Breno R. Barrioni, Juliana P. Vago, Jose Alcides A. de Arruda, Pedro D. Prazeres, Flavio A. Amaral, Tarcilia A. Silva, Soraia Macari
Summary: This study investigated the role of PI3K gamma in tooth movement and bone remodeling. The results showed that the deficiency or inhibition of PI3K gamma can reduce bone resorption and improve bone quality by increasing osteoblasts and decreasing osteoclasts. The PI3K gamma/Akt axis plays a crucial role in bone remodeling.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Paweena Dana, Nuttaporn Pimpha, Angkana Chaipuang, Nutthanit Thumrongsiri, Prattana Tanyapanyachon, Anukul Taweechaipaisankul, Walailuk Chonniyom, Natsorn Watcharadulyarat, Sith Sathornsumetee, Nattika Saengkrit
Summary: Chitosan-coated selenium nanoparticles (Cs-SeNPs) have been synthesized to reduce cell viability, inhibit cell migration and invasion, and improve chemotherapeutic drug sensitivity in glioma cells.
Article
Chemistry, Multidisciplinary
Dongmei Xi, Ning Xu, Xiang Xia, Chao Shi, Xiaojing Li, Dongsheng Wang, Saran Long, Jiangli Fan, Wen Sun, Xiaojun Peng
Summary: In this study, a photosensitizer assembly nanosystem was developed to enhance tumor retention for efficient photodynamic therapy. The long tumor retention time of the photosensitizer nanoparticles allowed for single-dose injection and multiple light treatments, resulting in a high inhibition rate of over 90% for tumor growth.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Ruibing An, Lingjun Liu, Shixuan Wei, Zheng Huang, Ling Qiu, Jianguo Lin, Hong Liu, Deju Ye
Summary: This study presents a glioma targeting and redox activatable theranostic nanoprobe for on-demand synergistic chemotherapy/photodynamic therapy (Chemo-PDT) of orthotopic gliomas. The nanoprobe disassembles and releases small molecules upon reduction by endogenous glutathione, allowing for synergistic Chemo-PDT. Additionally, the nanoprobe is capable of noninvasive detection and monitoring of orthotopic brain tumor growth. This research highlights the potential of targeted and activatable nanoagents for combinational cancer theranostics.
Article
Biochemistry & Molecular Biology
JeongMin Sim, JeongMan Park, Suwan Kim, Sojung Hwang, KyoungSu Sung, Jung-Eun Lee, SeungHo Yang, Kyunggi Cho, SungHwan Lee, Jong-Seok Moon, JuWon Ahn, Jaejoon Lim
Summary: The expression of Tim-3/Gal-9 is associated with glioma malignancy and poor prognosis, and they regulate the formation and activation of the NLRC4 inflammasome. A blockade of Tim-3/Gal-9 may be beneficial in glioma therapy by reducing the inflammatory microenvironment through downregulating the NLRC4 inflammasome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Jun Sun, Dong He, Yibing Fu, Rui Zhang, Hua Guo, Zhaojuan Wang, Yanan Wang, Taihong Gao, Yanbang Wei, Yuji Guo, Qi Pang, Qian Liu
Summary: The novel lncRNA ARST is significantly downregulated in gliomas, and overexpression of ARST suppresses vital cellular abilities in glioma cells, including cell growth, proliferation, migration, and invasion, ultimately reducing tumorigenicity in vivo. The tumor suppressive effects of ARST are mediated by direct binding to the glycolytic enzyme ALDOA, disrupting the interaction with actin cytoskeleton and altering the invasive properties of glioma cells. This highlights ARST as a potential target for glioma diagnosis, therapy, and prognosis.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Jintao Gu, Nan Mu, Bo Jia, Qingdong Guo, Luxiang Pan, Maorong Zhu, Wangqian Zhang, Kuo Zhang, Weina Li, Meng Li, Lichun Wei, Xiaochang Xue, Yingqi Zhang, Wei Zhang
Summary: This study presents a novel preclinical model for radiobiological studies and identifies a radiation-tolerant persister subpopulation that drives radioresistance by activating DNA damage repair and promoting stemness. The NF-kappa B-YY1-miR-103a regulatory axis is essential for the function of the radiation-tolerant persister cells. Furthermore, transferrin-functionalized nanoparticles improve radiosensitivity and provide a significant survival benefit.
Article
Medicine, General & Internal
Xu Wang, Yi Zhou, Yan Wang, Xiang Wang, Yu Zhang, Yufei Mao, Long Zhang, Ji Qi, Yining Zhang, Feng Lyu, Linbo Gu, Rutong Yu, Xiuping Zhou
Summary: SU4312 inhibits glioma progression by down-regulating YAP transcription and CCL2 secretion, and can enhance the antitumor effect of temozolomide.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Astronomy & Astrophysics
Wen-Fei Wang
Summary: In this study of kaon pair resonance contributions in hadronic decays, virtual contributions from rho(770) and omega(782) were found to have larger branching fractions than other resonances. Additionally, predictions for specific decay processes were shown to meet the requirements of SU(3) symmetry relations.
Article
Physics, Multidisciplinary
R. A. Mukhamedshin, T. Sadykov
Summary: A new phenomenological model (FANSY 2.0 QGSJ) based on the traditional quark-gluon string model has been developed to simulate meson-proton interactions in a wide energy range. The model successfully reproduces low-energy accelerator data and shows a general agreement between simulated results and experimental data. The relationship between the quark composition of the most energetic hadrons and the leading effect is discussed.
EUROPEAN PHYSICAL JOURNAL PLUS
(2021)
