Article
Hematology
Robert Wolf, Sophie Grammbauer, Raghavendra Palankar, Celine Tolksdorf, Eileen Moritz, Andreas Bohm, Mahmoud Hasan, Annika Hafkemeyer, Andreas Greinacher, Mladen Tzvetkov, Bernhard H. Rauch, Gabriele Jedlitschky
Summary: Selective inhibition of MRP4 can reduce platelet adhesion and thrombus formation through multiple mechanisms, including inhibition of integrin aIIbb3 activation, increased VASP phosphorylation, and reduced calcium influx.
Review
Biochemistry & Molecular Biology
Jenny P. Nguyen, Yechan Kim, Quynh Cao, Jeremy A. Hirota
Summary: ABC transporters play a crucial role in regulating lung health and disease, with ABCC7 and ABCC4 forming a macromolecular complex that impacts the transport of endogenous and exogenous substances in human airway epithelial cells.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ioannis Angelis, Vassilios Moussis, Demokritos C. Tsoukatos, Vassilios Tsikaris
Summary: This review focuses on the role of platelet receptor MRP4 in regulating platelet activation and accumulation, as well as its potential impact on aspirin tolerance and antiplatelet therapy.
PROTEIN AND PEPTIDE LETTERS
(2021)
Article
Biochemistry & Molecular Biology
David Kreutzer, Henry Doering, Peter Werner, Christoph A. Ritter, Andreas Hilgeroth
Summary: In recent decades, the development of drugs targeting molecular target structures in cancer cells has improved cancer treatment. However, ongoing resistance issues caused by mutations and the phenomenon of multidrug resistance continue to pose challenges. Studies on efflux pump-expressing cancer cells have shown promising effects of inhibitors, providing hope for future treatment methods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Xuejian Wang, Wenyan Jiang, Yanmei Du, Dongqi Zhu, Jian Zhang, Chunyan Fang, Fang Yan, Zhe-Sheng Chen
Summary: This review article summarizes the treatments and combination therapies that induce feedback activation of AKT, ERK, STAT3, EGFR, FGFR, and HER2/3 signaling pathways to enhance anti-tumor effect or overcome drug resistance. The underlying mechanisms of protein molecules involved in the feedback activation are explored. Clinical trials employing combination treatments to suppress feedback activation and improve therapeutic efficacy of cancer treatments are also reviewed.
DRUG RESISTANCE UPDATES
(2022)
Review
Biochemistry & Molecular Biology
Chuansheng Yang, Zhikai Mai, Can Liu, Shuanghong Yin, Yantao Cai, Chenglai Xia
Summary: Drug resistance remains a major obstacle in cancer therapy, but natural products have shown potential as effective substances against drug resistance. By reviewing the signaling pathways involved in tumor drug resistance and their inhibitors derived from natural products, new strategies for the prevention of drug resistance in cancer therapy can be explored.
Article
Oncology
Ruiqi Jiang, Mingnan Cao, Shenghui Mei, Shanshan Guo, Wei Zhang, Nan Ji, Zhigang Zhao
Summary: This study provides a comprehensive overview and identifies emerging trends in the metabolic signaling pathways of tumor drug resistance research. The findings suggest that the research on tumor metabolic reprogramming is rapidly advancing.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ukjin Lee, Eun-Young Cho, Eek-Hoon Jho
Summary: The Hippo signaling pathway plays a crucial role in maintaining the balance between cell proliferation and apoptosis, and its dysregulation is associated with tumor initiation, progression, and drug resistance.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Ajay C. Donepudi, Yoojin Lee, Ji-Young Lee, John D. Schuetz, Jose E. Manautou
Summary: The lack of Mrp4 expression is associated with adipocyte hypertrophy and increased blood glucose and leptin levels, impairing glucose tolerance. Inhibiting Mrp4 increases adipogenesis and alters adipogenic gene expression. Lack of Mrp4 activity leads to increased activation of Creb and decreased PGE levels, promoting the metabolic phenotype in Mrp4(-/-) mice.
Article
Biochemistry & Molecular Biology
Henry Doering, David Kreutzer, Christoph Ritter, Andreas Hilgeroth
Summary: Despite the development of targeted therapies in cancer, the issue of multidrug resistance (MDR) remains unresolved. This study discovered novel symmetric inhibitors of the efflux pump MRP4, which showed better activities than the best known MRP4 inhibitor MK571. One of the best compounds was able to overcome MRP4-mediated resistance in cell line models, restoring sensitivity to anticancer drugs.
Article
Pharmacology & Pharmacy
Ahmed E. Hamouda, Kai Schulze, Thomas Ebensen, Carlos Alberto Guzman, Dario Lirussi
Summary: Cyclic di-AMP (CDA) and di-GMP (CDG) are promising immune modulators that induce immune response in vaccination and cancer immunotherapy. The signaling of type I interferon (IFN-alpha/beta) is crucial for the activation and enhanced immunogenicity mediated by CDG and CDA.
Review
Oncology
Tina Paradzik, Cecilia Bandini, Elisabetta Mereu, Maria Labrador, Elisa Taiana, Nicola Amodio, Antonino Neri, Roberto Piva
Summary: Recent investigations are exploring novel combination strategies that could overcome drug resistance and broaden the applicability of proteasome inhibitors (PIs) to other hematological malignancies and solid tumors.
Review
Biochemistry & Molecular Biology
Delphine Mika, Rodolphe Fischmeister
Summary: The sinoatrial node is the natural pacemaker of the heart, tightly controlled by the autonomic nervous system and various factors, with neurohumoral regulation of heart rate playing a crucial role in integrating vital functions, behavior, and response to environmental changes. Cellular modulation of SAN activity occurs through intracellular signaling pathways involving cAMP and cGMP.
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Wenqiang Li, Mei Li, Qian Huang, Xiaoyu He, Chen Shen, Xiaoming Hou, Fulai Xue, Zhiping Deng, Yao Luo
Summary: Lung cancer is a leading cause of cancer-associated death worldwide, with non-small cell lung cancer being the most common type. The mechanisms of non-small cell lung cancer evolution involve complex alterations of multiple signaling pathways. Despite advances in understanding and treatment, there are still many challenges in treating non-small cell lung cancer. Nanoparticles have shown great potential in the diagnosis and treatment of tumors, delivering drugs to regulate specific molecular signaling pathways. This review summarizes the recent advances in therapeutic targets and nanoparticle-based drug delivery systems in non-small cell lung cancer, and presents future prospects and challenges.
FRONTIERS IN CHEMISTRY
(2023)
Review
Medicine, Research & Experimental
Xiaochuan Wu, Yong-zhong Du
Summary: More than half of the global population experiences hair loss, and conventional topical drugs have shown limited effectiveness. This review focuses on the crucial signaling pathways related to hair loss and highlights the potential of nanobased topical delivery systems for emerging treatment strategies.
MOLECULAR PHARMACEUTICS
(2023)
