Journal
CELL CYCLE
Volume 8, Issue 9, Pages 1329-1331Publisher
LANDES BIOSCIENCE
DOI: 10.4161/cc.8.9.8288
Keywords
TCAB1; telomerase; telomere; stem cells; cancer; Cajal body; WD repeat
Categories
Ask authors/readers for more resources
Telomerase supports the proliferation of progenitor cells and tumor cells by adding telomere repeats to chromosome ends. The low abundance and restricted expression pattern of telomerase have limited our knowledge of this important enzyme. A new telomerase protein, TCAB1, sheds light on the pathway that governs telomerase holoenzyme assembly and function in vivo. TCAB1 is a component of active telomerase and is required for the telomerase holoenzyme to accumulate in Cajal bodies and to elongate telomeres. These findings provide important new insights into how telomerase functions in cancer and in stem cell biology.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available